{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:34:16Z","timestamp":1791855256493,"version":"4.3.4"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["(AGL2016-75463-R)"],"award-info":[{"award-number":["(AGL2016-75463-R)"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Gobierno de Espa\u00f1a","award":["FPU grant (Formaci\u00f3n de Profesorado Universitario; FPU18\/00401)"],"award-info":[{"award-number":["FPU grant (Formaci\u00f3n de Profesorado Universitario; FPU18\/00401)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study was conducted to investigate the effects of dietary supplementation of porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination of both, on growth performance and the expression of genes related to intestinal function of weaned pigs. A total of 180 piglets (trial 1) and 198 piglets (trial 2) were used to evaluate the partial substitution of soybean ingredients with 2% SDP or 2% PDP (trial 1), and with 3% SDP or the combination of 1% SDP and 2% PDP (SDP-PDP; trial 2) during the pre-starter period (0\u201314 days). The gene expression of 56 genes was quantified in a qPCR platform in jejunum and ileum samples obtained from piglets 14 d after weaning (trial 2). Piglets fed SDP, PDP and SDP-PDP had a higher body weight (BW), average daily gain (ADG) and feed efficiency (G:F) than the soybean control on day 14 (p &lt; 0.05). In addition, the combination of SDP and PDP upregulated ten genes in jejunum samples (p &lt; 0.05) related to intestinal function. More research is needed to confirm that gene expression upregulation by PDP in combination with SDP has an impact on intestinal function and to elucidate its underlying mechanisms.<\/jats:p>","DOI":"10.3390\/ani10122368","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T20:18:22Z","timestamp":1607631502000},"page":"2368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-6240","authenticated-orcid":false,"given":"Francesc","family":"Gonz\u00e1lez-Sol\u00e9","sequence":"first","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-4131","authenticated-orcid":false,"given":"Lourdes","family":"Criado-Mesas","sequence":"additional","affiliation":[{"name":"Plant and Animal Genomics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Villodre","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-2085","authenticated-orcid":false,"given":"Wellington C.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"},{"name":"Department of Animal Production, Agrarian University of Ecuador,  Guayaquil 090108, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Area of Statistics and Operations Research, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-7459","authenticated-orcid":false,"given":"Elisabet","family":"Borda","sequence":"additional","affiliation":[{"name":"R&amp;D Animal Nutrition Department, Bioiberica S.A.U., 08389 Palafolls, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6243-9164","authenticated-orcid":false,"given":"Francisco J.","family":"P\u00e9rez-Cano","sequence":"additional","affiliation":[{"name":"Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain"},{"name":"Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-1303","authenticated-orcid":false,"given":"Josep M.","family":"Folch","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"},{"name":"Plant and Animal Genomics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-340X","authenticated-orcid":false,"given":"David","family":"Sol\u00e0-Oriol","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8853-8945","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Animal Nutrition and Welfare Service, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.livsci.2007.01.091","article-title":"Weaning\u2014A Challenge to Gut Physiologists","volume":"108","author":"Bosi","year":"2007","journal-title":"Livest. 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