{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:55:27Z","timestamp":1772085327500,"version":"3.50.1"},"reference-count":71,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872349"],"award-info":[{"award-number":["31872349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>CircRNAs have been identified to be expressed differently and stably in numerous species and tissues, but their functions in growth hormone (GH) secretion are still largely unknown. In summary, we have revealed a circRNA-miRNA-mRNA network that may play a biological role in the rat pituitary gland. First, we verified the chromosome location information of circAgtpbp1 according to sequencing analysis. The circAgtpbp1 characteristics were authenticated through PCR, qRT\u2013PCR, treating with RNase and fluorescent in situ hybridization (FISH). Second, we detected the expression pattern of circAgtpbp1 in the rat anterior pituitary by qRT\u2013PCR. We also designed circAgtpbp1 siRNA and constructed overexpression plasmid to evaluate the effect of circAgtpbp1 function on GH secretion by qRT\u2013PCR, ELISA and Western blot. CircAgtpbp1 is a stable, truly circular molecule. We found that circAgtpbp1 interacted with miR-543-5p and can regulate GH secretion in pituitary cells through a circAgtpbp1-miR-543-5p-GH axis. Overall, the evidence generated by our study suggests that circAgtpbp1 can act as a sponge of miR-543-5p to reduce the inhibitory effect of miR-543-5p on Gh1 and further promote GH secretion. These findings expand our existing knowledge on the mechanisms of hormone regulation in the pituitary gland.<\/jats:p>","DOI":"10.3390\/ani11020558","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T21:15:01Z","timestamp":1613942101000},"page":"558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CircAgtpbp1 Acts as a Molecular Sponge of miR-543-5p to Regulate the Secretion of GH in Rat Pituitary Cells"],"prefix":"10.3390","volume":"11","author":[{"given":"ZeWen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenZhi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-4916","authenticated-orcid":false,"given":"WeiDi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangJiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HaoQi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-2509","authenticated-orcid":false,"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3490-0755","authenticated-orcid":false,"given":"Bao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animals, College of Animal Sciences, Jilin University, 5333 Xi\u2019an Road, Changchun 130062, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/biolre\/ioy081","article-title":"Complex integration of intrinsic and peripheral signaling is required for pituitary gland development","volume":"99","author":"Edwards","year":"2018","journal-title":"Biol. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1293\/tox.31.1S","article-title":"Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System","volume":"31","author":"Balme","year":"2018","journal-title":"J. Toxicol. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1152\/physrev.00006.2006","article-title":"Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks","volume":"87","author":"Zhu","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1242\/dev.139055","article-title":"Development of the hypothalamus: Conservation, modification and innovation","volume":"144","author":"Xie","year":"2017","journal-title":"Development"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhang, H., Qi, Q., Chen, T., Luo, J., Xi, Q., Jiang, Q., Sun, J., and Zhang, Y. (2018). Age-Related Changes in MicroRNA in the Rat Pituitary and Potential Role in GH Regulation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072058"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/JOE-10-0456","article-title":"Differential regulation of Igf1 and Igf2 mRNA levels in tilapia hepatocytes: Effects of insulin and cortisol on GH sensitivity","volume":"211","author":"Pierce","year":"2011","journal-title":"J. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ygcen.2011.06.014","article-title":"New insights into the signaling system and function of insulin in fish","volume":"173","author":"Caruso","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1007\/s11033-012-2313-5","article-title":"The role of SOCS2 in recombinant human growth hormone (rhGH) regulating lipid metabolism in high-fat-diet-induced obesity mice","volume":"40","author":"Yang","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1530\/JME-13-0039","article-title":"PKC and ERK mediate GH-stimulated lipolysis","volume":"51","author":"Bergan","year":"2013","journal-title":"J. Mol. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrendo.2010.123","article-title":"The growth hormone receptor: Mechanism of activation and clinical implications","volume":"6","author":"Brooks","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2169\/internalmedicine.41.7","article-title":"Regulation of Human Growth Hormone Secretion and Its Disorders","volume":"41","author":"Kato","year":"2002","journal-title":"Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrc3215","article-title":"The insulin and insulin-like growth factor receptor family in neoplasia: An update","volume":"12","author":"Pollak","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.1081447","article-title":"The Endocrine Regulation of Aging by Insulin-like Signals","volume":"299","author":"Tatar","year":"2003","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lin, S., Li, C., Li, C., and Zhang, X. (2018). Growth Hormone Receptor Mutations Related to Individual Dwarfism. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051433"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physiolgenomics.00062.2015","article-title":"Identifying growth hormone-regulated enhancers in the Igf1 locus","volume":"47","author":"Alzhanov","year":"2015","journal-title":"Physiol. Genom."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ecl.2006.11.003","article-title":"Factors Regulating Growth Hormone Secretion in Humans","volume":"36","author":"Goldenberg","year":"2007","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_17","first-page":"55","article-title":"Growth Hormone and Bone","volume":"19","author":"Ohlsson","year":"1998","journal-title":"Endocr. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1152\/physrev.1999.79.2.511","article-title":"Neuroendocrine Control of Growth Hormone Secretion","volume":"79","author":"Locatelli","year":"1999","journal-title":"Physiol. Rev."},{"key":"ref_19","first-page":"MC13","article-title":"Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion","volume":"8","author":"Khatib","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.canlet.2018.05.033","article-title":"CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis","volume":"430","author":"Wu","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12648","DOI":"10.1111\/cpr.12648","article-title":"Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ","volume":"52","author":"Liu","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41419-019-1439-y","article-title":"Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression","volume":"10","author":"Cai","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/path.5238","article-title":"NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling","volume":"248","author":"Chen","year":"2019","journal-title":"J. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s12276-018-0056-7","article-title":"Circular RNA circ-4099 is induced by TNF-\u03b1 and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration","volume":"50","author":"Wang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-018-0892-z","article-title":"Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p\/p27 axis","volume":"17","author":"Xie","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13059-015-0801-3","article-title":"Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development","volume":"16","author":"Hansen","year":"2015","journal-title":"Genome Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Salzman, J., Chen, R.E., Olsen, M.N., Wang, P.L., and Brown, P.O. (2013). Cell-Type Specific Features of Circular RNA Expression. PLoS Genet., 9.","DOI":"10.1371\/annotation\/f782282b-eefa-4c8d-985c-b1484e845855"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12943-018-0771-7","article-title":"Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17\/miR-224 and regulating p21, PTEN expression","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12943-019-1081-4","article-title":"circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e12548","DOI":"10.1111\/cpr.12548","article-title":"Circ_0078767 suppresses non-small-cell lung cancer by protecting RASSF1A expression via sponging miR-330-3p","volume":"52","author":"Chen","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1080\/15384101.2018.1480210","article-title":"Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1","volume":"17","author":"Zhou","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, X., Li, C., Liu, Z., Ni, W., Yao, R., Xu, Y., Quan, R., Zhang, M., Li, H., and Liu, L. (2019). Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation. Cells, 8.","DOI":"10.3390\/cells8060616"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Chen, K., Hou, J., An, X., Song, Y., Zhang, X., Liu, Y., Zhang, G., Wen, K., Ma, H., and Li, G. (2018). Chi-miR-3031 regulates beta-casein via the PI3K\/AKT-mTOR signaling pathway in goat mammary epithelial cells (GMECs). BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1695-6"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/biolre\/ioz100","article-title":"Differentially expressed lncRNA-m433s1 regulates FSH secretion by functioning as a miRNA sponge in male rat anterior pituitary cells","volume":"101","author":"Han","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yu, Z.-W., Gao, W., Feng, X.-Y., Zhang, J.-Y., Guo, H.-X., Wang, C.-J., Chen, J., Hu, J.-P., Ren, W.-Z., and Yuan, B. (2019). Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222340"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1261\/rna.5248604","article-title":"Fast and effective prediction of microRNA\/target duplexes","volume":"10","author":"Rehmsmeier","year":"2004","journal-title":"RNA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1530\/JOE-18-0540","article-title":"Identification of circular RNAs in the immature and mature rat anterior pituitary","volume":"240","author":"Han","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","article-title":"Circular RNA: A new star of noncoding RNAs","volume":"365","author":"Qu","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.tig.2016.03.002","article-title":"Circular RNA Expression: Its Potential Regulation and Function","volume":"32","author":"Salzman","year":"2016","journal-title":"Trends Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nsmb.2959","article-title":"Exon-intron circular RNAs regulate transcription in the nucleus","volume":"22","author":"Li","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s13059-014-0409-z","article-title":"Expanded identification and characterization of mammalian circular RNAs","volume":"15","author":"Guo","year":"2014","journal-title":"Genome Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13059-015-0690-5","article-title":"Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development","volume":"16","author":"Szabo","year":"2015","journal-title":"Genome Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ghir.2014.12.002","article-title":"Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH","volume":"25","author":"Qi","year":"2015","journal-title":"Growth Horm. IGF Res."},{"key":"ref_47","first-page":"39","article-title":"Analgesic effects of natural growth hormone release inhibitors and their synthetic analogs. Intraspinal administration","volume":"88","author":"Beltrutti","year":"1997","journal-title":"Minerva Med."},{"key":"ref_48","first-page":"99","article-title":"Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals","volume":"46","author":"Cella","year":"1993","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1210\/endo-121-4-1251","article-title":"Age-Related Decrease of Growth Hormone and Prolactin Gene Expression in the Mouse Pituitary","volume":"121","author":"Crew","year":"1987","journal-title":"Endocrinology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1210\/endo-107-6-1875","article-title":"Decreased Pulsatile Release of Growth Hormone in Old Male Rats*","volume":"107","author":"Sonntag","year":"1980","journal-title":"Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ghir.2008.05.005","article-title":"Role of the GH\/IGF-1 axis in lifespan and healthspan: Lessons from animal models","volume":"18","author":"Berryman","year":"2008","journal-title":"Growth Horm. IGF Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1210\/jc.2002-021938","article-title":"Reduced Longevity in Untreated Patients with Isolated Growth Hormone Deficiency","volume":"88","author":"Besson","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000073704","article-title":"Can Growth Hormone (GH) Accelerate Aging? Evidence from GH-Transgenic Mice","volume":"78","author":"Bartke","year":"2003","journal-title":"Neuroendocrinology"},{"key":"ref_54","first-page":"2730","article-title":"Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study","volume":"83","author":"Orme","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_55","first-page":"75","article-title":"GH and mortality in acromegaly","volume":"28","author":"Sheppard","year":"2005","journal-title":"J. Endocrinol. Invest."},{"key":"ref_56","first-page":"1","article-title":"The effect of miR-93 on GH secretion in pituitary cells of Yanbian yellow cattle","volume":"10","author":"Lou","year":"2019","journal-title":"Anim. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e7728","DOI":"10.1590\/1414-431x20197728","article-title":"Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells","volume":"52","author":"Rui","year":"2019","journal-title":"Braz. J. Med Biol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11215","DOI":"10.1038\/ncomms11215","article-title":"Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/15476286.2016.1271524","article-title":"Insights into circular RNA biology","volume":"14","author":"Ebbesen","year":"2017","journal-title":"RNA Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA Biogenesis Competes with Pre-mRNA Splicing","volume":"56","author":"Meyer","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"31313","DOI":"10.1038\/srep31313","article-title":"CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs","volume":"6","author":"Schneider","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e12661","DOI":"10.1111\/cpr.12661","article-title":"Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195\/GPRC5A signalling","volume":"52","author":"Liang","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12943-019-1040-0","article-title":"Circular RNA circSLC8A1 acts as a sponge of miR-130b\/miR-494 in suppressing bladder cancer progression via regulating PTEN","volume":"18","author":"Lu","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1080\/15384101.2018.1526599","article-title":"Circular RNA 101368\/miR-200a axis modulates the migration of hepatocellular carcinoma through HMGB1\/RAGE signaling","volume":"17","author":"Li","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-018-0930-x","article-title":"Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_66","first-page":"592","article-title":"Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506","volume":"10","author":"Ma","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13046-018-0936-7","article-title":"CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of \u03b2-catenin pathway","volume":"37","author":"Bi","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9168","DOI":"10.1002\/jcb.27181","article-title":"MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells","volume":"119","author":"He","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chen, X., Su, X., Zhu, C., and Zhou, J. (2019). Knockdown of hsa_circ_0023028 inhibits cell proliferation, migration, and invasion in laryngeal cancer by sponging miR-194-5p. Biosci. Rep., 39.","DOI":"10.1042\/BSR20190177"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.omtn.2019.03.009","article-title":"Circular RNA SNX29 Sponges miR-744 to Regulate Proliferation and Differentiation of Myoblasts by Activating the Wnt5a\/Ca2+ Signaling Pathway","volume":"16","author":"Peng","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.omtn.2018.02.012","article-title":"circFGFR4 Promotes Differentiation of Myoblasts via Binding miR-107 to Relieve Its Inhibition of Wnt3a","volume":"11","author":"Li","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/2\/558\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:27:01Z","timestamp":1760160421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/2\/558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,20]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["ani11020558"],"URL":"https:\/\/doi.org\/10.3390\/ani11020558","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,20]]}}}