{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:06:43Z","timestamp":1767276403660,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Acid base homeostasis and urine pH is influenced by the dietary cation anion balance (DCAB) in many species. Here, a negative DCAB acidifies the urine, while higher DCABs alkalize the urine. The dimension of the DCAB effect can be species-specific, because of differences in urine buffer systems. The aim of the present study was to describe the response of laboratory mice to diets with different DCAB. We used 8-week-old wildtype male mice of the C57Bl\/6J inbred strain and CD1 outbred stock. Three groups (n = 15 animals\/group) were formed and fed standard diet A for adaptation. For the 7-week feeding trial, mice were either kept on diet A (DCAB \u22127 mmol\/kg dry matter (DM) or switched to diet B (246 mmol\/kg DM) or C (\u2212257 mmol\/kg DM). Urine pH was measured weekly from a pooled sample per cage. There was a significant difference in the basal urine pH on diet A between C57Bl6\/J and CD1 mice. The shift in urine pH was also significantly different between the two groups investigated.<\/jats:p>","DOI":"10.3390\/ani11030702","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T11:46:09Z","timestamp":1614944769000},"page":"702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of Strain and Diet on Urinary pH in Laboratory Mice"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-335X","authenticated-orcid":false,"given":"Linda F.","family":"B\u00f6swald","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Dietetics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Sch\u00f6nleutnerstr. 8, 85764 Oberschlei\u00dfheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Matzek","sequence":"additional","affiliation":[{"name":"Biomedical Center, Core Facility Animal Models, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t Munich, Gro\u00dfhaderner Stra\u00dfe 9, 82152 Planegg-Martinsried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Kienzle","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Dietetics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Sch\u00f6nleutnerstr. 8, 85764 Oberschlei\u00dfheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-695X","authenticated-orcid":false,"given":"Bastian","family":"Popper","sequence":"additional","affiliation":[{"name":"Biomedical Center, Core Facility Animal Models, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t Munich, Gro\u00dfhaderner Stra\u00dfe 9, 82152 Planegg-Martinsried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"ref_1","first-page":"17","article-title":"Untersuchungen zur Einstellung des Harn-pH-Wertes bei Sauen","volume":"1","author":"Beker","year":"1999","journal-title":"Lohmann Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-0038-1623685","article-title":"Vitamin-a-exzess durch Pferdefleischprodukte mit hohen Leberanteilen","volume":"41","author":"Becker","year":"2013","journal-title":"Tier\u00e4rztliche Prax. 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