{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:53:17Z","timestamp":1760233997860,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>We reviewed the definitions and methods of assessment of gastro-oesophageal reflux (GOR) in anaesthetized dogs. Three databases were used. Titles and abstracts were screened by two of the authors independently. A total of 22 studies was included in the analysis. The definition of GOR implied the presence of fluids not reaching the mouth or nose in the oesophagus in all studies. Most studies considered a change in pH using oesophageal pH meters as the sole method of assessment. Calibration of the pH probe was inconsistently reported. The position of the tip of the oesophageal probe was inconsistent and not always precisely described. The correct positioning in the intended location was verified in a limited number of studies. Some studies considered that GOR had happened for changes in pH below 4.0 or above 7.5 while others considered that GOR had happened when the pH dropped below 4.0 only. Some studies stated that the pH change had to be sustained for a minimum period of time (20 or 30 s) whereas others did not mention any duration. The variability of definitions and methods of assessment of GOR in anaesthetized dogs precludes meaningful comparison of the findings. Re-evaluation and uniformization of the methods appear necessary.<\/jats:p>","DOI":"10.3390\/ani11030852","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T22:19:36Z","timestamp":1616105976000},"page":"852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Systematic Review of the Methods of Assessment of Gastro-Oesophageal Reflux in Anaesthetized Dogs"],"prefix":"10.3390","volume":"11","author":[{"given":"Anna Carolina","family":"Fernandez Alasia","sequence":"first","affiliation":[{"name":"School of Veterinary Science, Faculty of Science, Evelyn Williams Building No B10, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-4682","authenticated-orcid":false,"given":"Olivier","family":"Levionnois","sequence":"additional","affiliation":[{"name":"Anaesthesiology Section, Department of Clinical Veterinary Sciences, Vetsuisse Faculty, University of Berne, 3012 Berne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-9312","authenticated-orcid":false,"given":"Mathieu","family":"Raillard","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, Faculty of Science, Evelyn Williams Building No B10, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1467-2995.2011.00704.x","article-title":"The risk of passive regurgitation during general anaesthesia in a population of referred dogs in the UK","volume":"39","author":"Lamata","year":"2012","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2460\/ajvr.2005.66.386","article-title":"Effects of preanesthetic administration of morphine on gastroesophageal reflux and regurgitation during anesthesia in dogs","volume":"66","author":"Wilson","year":"2005","journal-title":"Am. J. Vet. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.5326\/JAAHA-MS-6399","article-title":"A \u201cLight Meal\u201d Three Hours Preoperatively Decreases the Incidence of Gastro-Esophageal Reflux in Dogs","volume":"52","author":"Savvas","year":"2016","journal-title":"J. Am. Anim. Hosp. Assoc."},{"doi-asserted-by":"crossref","unstructured":"Lambertini, C., Pietra, M., Galiazzo, G., Torresan, F., Pinna, S., Pisoni, L., and Romagnoli, N. (2020). Incidence of Gastroesophageal Reflux in Dogs Undergoing Orthopaedic Surgery or Endoscopic Evaluation of the Upper Gastrointestinal Tract. Vet. Sci., 7.","key":"ref_4","DOI":"10.3390\/vetsci7040144"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1532-950X.1990.tb01147.x","article-title":"Effects of atropine and glycopyrrolate on esophageal, gastric, and tracheal pH in anesthetized dogs","volume":"19","author":"Roush","year":"1990","journal-title":"Vet. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/vr.137.20.513","article-title":"Gastro-oesophageal reflux during anaesthesia in the dog: The effect of age, positioning and type of surgical procedure","volume":"137","author":"Galatos","year":"1995","journal-title":"Vet. Rec."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1136\/vr.137.19.479","article-title":"Gastro-oesophageal reflux during anaesthesia in the dog: The effect of preoperative fasting and premedication","volume":"137","author":"Galatos","year":"1995","journal-title":"Vet. Rec."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2460\/ajvr.67.11.1821","article-title":"Influence of halothane, isoflurane, and sevoflurane on gastroesophageal reflux during anesthesia in dogs","volume":"67","author":"Wilson","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2460\/ajvr.67.1.26","article-title":"Influence of metoclopramide on gastroesophageal reflux in anesthetized dogs","volume":"67","author":"Wilson","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1467-2995.2006.00295.x","article-title":"Pre-anesthetic meperidine: Associated vomiting and gastroesophageal reflux during the subsequent anesthetic in dogs","volume":"34","author":"Wilson","year":"2007","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1467-2995.2006.00340.x","article-title":"The effect of topical treatment on esophageal pH during acid reflux in dogs","volume":"34","author":"Wilson","year":"2007","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1467-2995.2009.00462.x","article-title":"Effect of endogenous progesterone and oestradiol-17beta on the incidence of gastro-oesophageal reflux and on the barrier pressure during general anaesthesia in the female dog","volume":"36","author":"Anagnostou","year":"2009","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1748-5827.2009.00818.x","article-title":"The effect of omeprazole on oesophageal pH in dogs during anaesthesia","volume":"50","author":"Panti","year":"2009","journal-title":"J. Small Anim. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11259-011-9471-0","article-title":"Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia","volume":"35","author":"Favarato","year":"2011","journal-title":"Vet. Res. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.rvsc.2011.07.027","article-title":"Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs","volume":"93","author":"Favarato","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1939-1676.2012.00929.x","article-title":"The influence of esomeprazole and cisapride on gastroesophageal reflux during anesthesia in dogs","volume":"26","author":"Zacuto","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/vaa.12120","article-title":"Maropitant prevented vomiting but not gastroesophageal reflux in anesthetized dogs premedicated with acepromazine-hydromorphone","volume":"41","author":"Johnson","year":"2014","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/vaa.12234","article-title":"The effect of the stage of the ovarian cycle (anoestrus or dioestrus) and of pregnancy on the incidence of gastro-oesophageal reflux in dogs undergoing ovariohysterectomy","volume":"42","author":"Anagnostou","year":"2015","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/vaa.12404","article-title":"Gastro-oesophageal reflux in large-sized, deep-chested versus small-sized, barrel-chested dogs undergoing spinal surgery in sternal recumbency","volume":"44","author":"Anagnostou","year":"2017","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5326\/JAAHA-MS-6281","article-title":"Evaluation of Gastroesophageal Reflux in Anesthetized Dogs with Brachycephalic Syndrome","volume":"53","author":"Shaver","year":"2017","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/vec.12613","article-title":"Prevalence of and risk factors for intraoperative gastroesophageal reflux and postanesthetic vomiting and diarrhea in dogs undergoing general anesthesia","volume":"27","author":"Torrente","year":"2017","journal-title":"J. Vet. Emerg. Crit. Care (San Antonio)"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2460\/ajvr.78.2.144","article-title":"Effect of the duration of food withholding prior to anesthesia on gastroesophageal reflux and regurgitation in healthy dogs undergoing elective orthopedic surgery","volume":"78","author":"Viskjer","year":"2017","journal-title":"Am. J. Vet. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.4142\/jvs.2020.21.e84","article-title":"Computed tomographic features of gastric and esophageal content in dogs undergoing CT myelography and factors influencing the presence of esophageal fluid","volume":"21","author":"Benzimra","year":"2020","journal-title":"J. Vet. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/s5040209","article-title":"On Calibration of pH Meters","volume":"5","author":"Cheng","year":"2005","journal-title":"Sensors"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/vr.129.12.261","article-title":"Measurement of the length and position of the lower oesophageal sphincter by correlation of external measurements and radiographic estimations in dogs","volume":"129","author":"Waterman","year":"1991","journal-title":"Vet. Rec."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1748-5827.1978.tb05532.x","article-title":"Reflux oesophagitis and stricture formation after anaesthesia: A review of seven cases in dogs and cats","volume":"19","author":"Pearson","year":"1978","journal-title":"J. Small Anim. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/vaa.12110","article-title":"Prevalence and risk factors for canine post-anesthetic aspiration pneumonia (1999-2009): A multicenter study","volume":"41","author":"Ovbey","year":"2014","journal-title":"Vet. Anaesth. Analg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/gut.44.5.598","article-title":"Toxic bile acids in gastro-oesophageal reflux disease: Influence of gastric acidity","volume":"44","author":"Nehra","year":"1999","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1365-2168.1998.00533.x","article-title":"Assessment of combined bile acid and pH profiles using an automated sampling device in gastro-oesophageal reflux disease","volume":"85","author":"Nehra","year":"1998","journal-title":"Br. J. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/vsu.12539","article-title":"Prospective Controlled Study of Gastroesophageal Reflux in Dogs with Naturally Occurring Laryngeal Paralysis","volume":"45","author":"Tarvin","year":"2016","journal-title":"Vet. Surg."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/3\/852\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:37:51Z","timestamp":1760161071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/3\/852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["ani11030852"],"URL":"https:\/\/doi.org\/10.3390\/ani11030852","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2021,3,18]]}}}