{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:02:08Z","timestamp":1788814928663,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1I1A3A04038058"],"award-info":[{"award-number":["NRF-2020R1I1A3A04038058"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>As environmental temperatures continue to rise, heat stress (HS) is having a negative effect on the livestock industry. In order to solve this problem, many studies have been conducted to reduce HS. Among them, early heat exposure has been suggested as a method for reducing HS in poultry. In this study, we analyzed proteomics and tried to identify the metabolic mechanisms of early heat exposure on acute HS. A total of 48 chicks were separated into three groups: CC (control groups raised at optimum temperature), CH (raised with CC but exposed acute HS at the 35th day), and HH (raised with CC but exposed early heat at the fifth day and acute HS at the 35th day). After the whole period, liver samples were collected for proteomic analysis. A total of 97 differentially expressed proteins were identified by acute HS. Of these, 62 proteins recovered their expression levels by early heat exposure. We used these 62 proteins to determine the protective effects of early heat exposure. Of the various protein-related terms, we focused on the oxidative phosphorylation, fatty acid metabolism, carbohydrate metabolism, and energy production metabolism. Our findings suggest the possibility of early heat exposure effects in acute HS that may be useful in breeding or management techniques for producing broilers with high heat resistance.<\/jats:p>","DOI":"10.3390\/ani11051338","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T21:32:46Z","timestamp":1620595966000},"page":"1338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early Heat Exposure Effects on Proteomic Changes of the Broiler Liver under Acute Heat Stress"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1659-4427","authenticated-orcid":false,"given":"Darae","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Animal Biotechnology, College of Agriculture Life Science, Jeonbuk National University, Jeonbuk 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanseob","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, College of Agriculture Life Science, Jeonbuk National University, Jeonbuk 54896, Korea"},{"name":"Department of Agricultural Coveragence Technology, College of Agriculture Life Science, Jeonbuk National University, Jeonbuk 54896, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/japr\/16.2.206","article-title":"Apparent metabolizable energy needs of broilers from two to four kilograms as influenced by ambient temperature","volume":"16","author":"Dozier","year":"2007","journal-title":"J. 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