{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:00:05Z","timestamp":1783998005740,"version":"3.55.0"},"reference-count":112,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Grant\/Award Number: 423558\/2018\u20108"],"award-info":[{"award-number":["Grant\/Award Number: 423558\/2018\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INCT - Ci\u00eancia Animal","award":["Grant\/Award Number: 465377\/2014\u20109."],"award-info":[{"award-number":["Grant\/Award Number: 465377\/2014\u20109."]}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["CVZ APQ 03434\/16"],"award-info":[{"award-number":["CVZ APQ 03434\/16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Grant\/Award Number: 320.020.170.11pq"],"award-info":[{"award-number":["Grant\/Award Number: 320.020.170.11pq"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PROEX: 0577\/2018"],"award-info":[{"award-number":["PROEX: 0577\/2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Since pre- and postnatal development are programmed during early prenatal life, studies addressing the complete transcriptional landscape during organogenesis are needed. Therefore, we aimed to disentangle differentially expressed (DE) genes between fetuses (at 35 days old) and embryos (at 25 days old) through RNA-sequencing analysis using the pig as model. In total, 1705 genes were DE, including the top DE IBSP, COL6A6, HBE1, HBZ, HBB, and NEUROD6 genes, which are associated with developmental transition from embryos to fetuses, such as ossification, skeletal muscle development, extracellular matrix organization, cardiovascular system, erythrocyte differentiation, and neuronal system. In pathway analysis, embryonic development highlighted those mainly related to morphogenic signaling and cell interactions, which are crucial for transcriptional control during the establishment of the main organs in early prenatal development, while pathways related to myogenesis, neuronal development, and cardiac and striated muscle contraction were enriched for fetal development, according to the greater complexity of organs and body structures at this developmental stage. Our findings provide an exploratory and informative transcriptional landscape of pig organogenesis, which might contribute to further studies addressing specific developmental events in pigs and in other mammals.<\/jats:p>","DOI":"10.3390\/ani11051443","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T12:17:16Z","timestamp":1621340236000},"page":"1443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcription Landscape of the Early Developmental Biology in Pigs"],"prefix":"10.3390","volume":"11","author":[{"given":"Susana A.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-7465","authenticated-orcid":false,"given":"Daniele B. D.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-2004","authenticated-orcid":false,"given":"Haniel C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eula R.","family":"Carrara","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walmir da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-3529","authenticated-orcid":false,"given":"Mariana M.","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-8879","authenticated-orcid":false,"given":"Adriana M. 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