{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:37:14Z","timestamp":1784237834181,"version":"3.55.0"},"reference-count":93,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin Province Science and Technology Development Project","award":["20200301019RQ"],"award-info":[{"award-number":["20200301019RQ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This experiment investigated the effect of vitamin A supplementation on growth, serum biochemical parameters, jejunum morphology and the microbial community in male growing-furring mink. Thirty healthy male mink were randomly assigned to three treatment groups, with 10 mink per group. Each mink was housed in an individual cage. The mink in the three groups were fed diets supplemented with vitamin A acetate at dosages of 0 (CON), 20,000 (LVitA) and 1,280,000 IU\/kg (HVitA) of basal diet. A 7-day pretest period preceded a formal test period of 45 days. The results show that 20,000 IU\/kg vitamin A increased the ADG, serum T-AOC and GSH-Px activities, villus height and villus height\/crypt depth ratio (p &lt; 0.05). The mRNA expression levels of IL-22, Occludin and ZO-1 in the jejunum of mink were significantly higher in the LVitA group than those in the CON and HVitA groups (p &lt; 0.05). Vitamin A supplementation increased the diversity of jejunum bacteria, decreased the ratio of Firmicutes to Bacteroidetes and increased the relative abundance of Akkermansia, uncultured bacterium f Muribaculaceae, Allobaculum, Lachnospiraceae NK4A136 group, Rummeliibacillus and Parasutterella. The comparison of potential functions also showed enrichment of glycan biosynthesis and metabolism, transport and catabolism pathways in the vitamin A supplementation groups compared with the CON group. In conclusion, these results indicate that dietary vitamin A supplementation could mediate host growth by improving intestinal development, immunity and the relative abundance of the intestinal microbiota.<\/jats:p>","DOI":"10.3390\/ani11061577","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T11:33:20Z","timestamp":1622201600000},"page":"1577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Vitamin A Supplementation on Growth Performance, Serum Biochemical Parameters, Intestinal Immunity Response and Gut Microbiota in American Mink (Neovison vison)"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-329X","authenticated-orcid":false,"given":"Weixiao","family":"Nan","sequence":"first","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"},{"name":"College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-5047","authenticated-orcid":false,"given":"Huazhe","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"},{"name":"College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongpeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tietao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Special Animal Nutrition and Feed, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.2218545","article-title":"Transport and Storage of Vitamin A","volume":"250","author":"Blomhoff","year":"1990","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1080\/10408398.2015.1060940","article-title":"Vitamin A and the Epigenome","volume":"57","author":"Reifen","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ncp.10376","article-title":"The Role of Vitamin A in Wound Healing","volume":"34","author":"Polcz","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_4","first-page":"71","article-title":"The pleiotropic role of vitamin A in regulating mucosal immunity","volume":"33","author":"Sirisinha","year":"2015","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Timoneda, J., Rodr\u00edguez-Fern\u00e1ndez, L., Zaragoz\u00e1, R., Mar\u00edn, M.P., Cabezuelo, M.T., Torres, L., Vi\u00f1a, J.R., and Barber, T. (2018). Vitamin A Deficiency and the Lung. Nutrients, 10.","DOI":"10.3390\/nu10091132"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/ijmr.IJMR_1781_18","article-title":"National Control Programme against Nutritional Blindness Due to Vitamin A Deficiency: Current Status & Future Strategy","volume":"148","author":"Vijayaraghavan","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pharmtox.39.1.399","article-title":"Teratology of Retinoids","volume":"39","author":"Collins","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ajcn\/83.2.191","article-title":"The Acute and Chronic Toxic Effects of Vitamin A","volume":"83","author":"Penniston","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1074\/jbc.M807503200","article-title":"Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin","volume":"284","author":"Shih","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chelstowska, S., Widjaja-Adhi, M.A.K., Silvaroli, J.A., and Golczak, M. (2016). Molecular Basis for Vitamin A Uptake and Storage in Vertebrates. Nutrients, 8.","DOI":"10.3390\/nu8110676"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Saeed, A., Dullaart, R.P.F., Schreuder, T.C.M.A., Blokzijl, H., and Faber, K.N. (2018). Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients, 10.","DOI":"10.3390\/nu10010029"},{"key":"ref_12","unstructured":"Marriott, B.P., Birt, D.F., Stallings, V.A., and Yates, A.A. (2020). Present Knowledge in Nutrition, Academic Press. [11th ed.]."},{"key":"ref_13","unstructured":"Council, N.R. (1982). Nutrient Requirements of Mink and Foxes, National Academy Press. [2nd ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"McDowell, L.R. (1989). Vitamins in Animal Nutrition, Academic Press.","DOI":"10.1016\/B978-0-12-483372-2.50012-6"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Compo, N.R., Gomez, D.E., Tapscott, B., Weese, J.S., and Turner, P.V. (2018). Fecal Bacterial Microbiota of Canadian Commercial Mink (Neovison Vison): Yearly, Life Stage, and Seasonal Comparisons. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0207111"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1139\/o62-155","article-title":"The Rate of Passage of Feed through the Digestive Tract of the Mink","volume":"40","author":"Sibbald","year":"1962","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Biasato, I., Ferrocino, I., Biasibetti, E., Grego, E., Dabbou, S., Sereno, A., Gai, F., Gasco, L., Schiavone, A., and Cocolin, L. (2018). Modulation of Intestinal Microbiota, Morphology and Mucin Composition by Dietary Insect Meal Inclusion in Free-Range Chickens. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1690-y"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.biotechadv.2012.12.009","article-title":"Gut Microbiota, Host Health, and Polysaccharides","volume":"31","author":"Xu","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The Gut Microbiota\u2014Masters of Host Development and Physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/1462-2920.12022","article-title":"Diet and Phylogeny Shape the Gut Microbiota of Antarctic Seals: A Comparison of Wild and Captive Animals","volume":"15","author":"Nelson","year":"2013","journal-title":"Environ. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40168-018-0501-9","article-title":"Microbial Diversity and Community Composition of Caecal Microbiota in Commercial and Indigenous Indian Chickens Determined Using 16s rDNA Amplicon Sequencing","volume":"6","author":"Pandit","year":"2018","journal-title":"Microbiome"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1111\/bph.13965","article-title":"Antibiotic-Induced Dysbiosis of the Microbiota Impairs Gut Neuromuscular Function in Juvenile Mice: Gut Dysbiosis Impairs Neuromuscular Function","volume":"174","author":"Caputi","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1155725","article-title":"Evolution of Mammals and Their Gut Microbes","volume":"320","author":"Ley","year":"2008","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/10409238.2019.1611734","article-title":"Vitamin A and Vitamin D Regulate the Microbial Complexity, Barrier Function, and the Mucosal Immune Responses to Ensure Intestinal Homeostasis","volume":"54","author":"Cantorna","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Iyer, N., and Vaishnava, S. (2019). Vitamin A at the Interface of Host\u2013Commensal\u2013Pathogen Interactions. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007750"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114898","DOI":"10.1016\/j.anifeedsci.2021.114898","article-title":"Effect of Dietary Vitamin A Supplementation on Growth Performance, Nutrient Digestibility, Serum Parameters and Liver Histology of Growing-Furring Male Mink Kits (Neovison Vison)","volume":"276","author":"Nan","year":"2021","journal-title":"Anim. Feed Sci. Tech."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Broom, D.M., and Fraser, A.F. (2007). Domestic Animal Behaviour and Welfare, CABI. [4th ed.].","DOI":"10.1079\/9781845932879.0000"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: Fast Length Adjustment of Short Reads to Improve Genome Assemblies","volume":"27","author":"Salzberg","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME Allows Analysis of High-Throughput Community Sequencing Data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: Highly Accurate OTU Sequences from Microbial Amplicon Reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA Ribosomal RNA Gene Database Project: Improved Data Processing and Web-Based Tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_33","first-page":"345","article-title":"Species Assemblages and Indicator Species: The Need for a Flexible Asymmetrical Approach","volume":"67","author":"Dufrene","year":"1997","journal-title":"Ecol. Monogr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1073\/pnas.1000162107","article-title":"Forensic Identification Using Skin Bacterial Communities","volume":"107","author":"Fierer","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive Functional Profiling of Microbial Communities Using 16S rRNA Marker Gene Sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_36","unstructured":"(2012). Graphpad Prism, GraphPad Software, Inc."},{"key":"ref_37","unstructured":"(2016). SPSS (Statistical Product and Service Solutions), IBM SPSS Inc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S0029665199000403","article-title":"The Effect of Vitamin A on Epithelial Integrity","volume":"58","author":"McCullough","year":"1999","journal-title":"Proc. Nutr. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3945\/jn.109.119388","article-title":"Vitamin A Deficiency Increases Protein Catabolism and Induces Urea Cycle Enzymes in Rats","volume":"140","author":"Cabezuelo","year":"2010","journal-title":"J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/jn\/nxz034","article-title":"Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age","volume":"149","author":"Huda","year":"2019","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jnutbio.2017.10.011","article-title":"Vitamin A Deficiency in Mice Alters Host and Gut Microbial Metabolism Leading to Altered Energy Homeostasis","volume":"54","author":"Tian","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","unstructured":"Leoschke, W.L. (2011). Nutrition and Nutritional Physiology of the Mink, Trafford Publishing."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.3382\/ps\/pez432","article-title":"The Effect of Dietary Vitamin A Supplementation in Maternal and Its Offspring on the Early Growth Performance, Liver Vitamin A Content, and Antioxidant Index of Goslings","volume":"98","author":"Liang","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00394-017-1466-3","article-title":"Comparison of the Effects of Three Different Baccaurea Angulata Whole Fruit Juice Doses on Plasma, Aorta and Liver MDA Levels, Antioxidant Enzymes and Total Antioxidant Capacity","volume":"57","author":"Ibrahim","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ijbiomac.2020.12.222","article-title":"Effects of Hericium Erinaceus Polysaccharide on Immunity and Apoptosis of the Main Immune Organs in Muscovy Duck Reovirus-Infected Ducklings","volume":"171","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/bi982291i","article-title":"The Structure of Human Retinol-Binding Protein (RBP) with Its Carrier Protein Transthyretin Reveals an Interaction with the Carboxy Terminus of RBP","volume":"38","author":"Naylor","year":"1999","journal-title":"Biochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0305-0491(93)90121-K","article-title":"Antioxidant Systems and Erythrocyte Life-Span in Mammals","volume":"106","author":"Kurata","year":"1993","journal-title":"Comp. Biochem. Physiol. Part B Comp. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/1381612003401190","article-title":"The Importance of Vitamin A in Nutrition","volume":"6","author":"Dawson","year":"2000","journal-title":"Curr. Pharm. Des."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/ajcn\/69.5.937","article-title":"Effects of Long-Term Intake of Retinol on Selected Clinical and Laboratory Indexes","volume":"69","author":"Cartmel","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7393620","DOI":"10.1155\/2016\/7393620","article-title":"Meeting the Vitamin A Requirement: The Efficacy and Importance of \u03b2-Carotene in Animal Species","volume":"2016","author":"Green","year":"2016","journal-title":"Sci. World J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3389\/fmicb.2017.01073","article-title":"Live Probiotic Lactobacillus Johnsonii BS15 Promotes Growth Performance and Lowers Fat Deposition by Improving Lipid Metabolism, Intestinal Development, and Gut Microflora in Broilers","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.3382\/ps\/pez111","article-title":"Effects of Lysophospholipid on Growth Performance, Carcass Yield, Intestinal Development, and Bone Quality in Broilers","volume":"98","author":"Chen","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12011-013-9792-7","article-title":"Dietary Nickel Chloride Restrains the Development of Small Intestine in Broilers","volume":"155","author":"Wu","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-94-024-0945-1_4","article-title":"Vitamin A Absorption, Storage and Mobilization","volume":"81","author":"Blaner","year":"2016","journal-title":"Subcell. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3945\/jn.117.247577","article-title":"Single High-Dose Vitamin A Supplementation to Neonatal Piglets Results in a Transient Dose Response in Extrahepatic Organs and Sustained Increases in Liver Stores","volume":"147","author":"Gannon","year":"2017","journal-title":"J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1084\/jem.20121588","article-title":"Retinoic Acid Expression Associates with Enhanced IL-22 Production by \u03b3\u03b4 T Cells and Innate Lymphoid Cells and Attenuation of Intestinal Inflammation","volume":"210","author":"Mielke","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cell.2017.07.027","article-title":"Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.immuni.2018.11.018","article-title":"Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis","volume":"49","author":"Zhong","year":"2018","journal-title":"Immunity"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1053\/j.gastro.2004.01.007","article-title":"Mechanisms of Cross Hyporesponsiveness to Toll-like Receptor Bacterial Ligands in Intestinal Epithelial Cells","volume":"126","author":"Otte","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1124\/mol.106.029579","article-title":"Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor Alpha Agonists in Colitis","volume":"71","author":"Osanai","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2017.12.016","article-title":"Ulinastatin Protects Brain against Cerebral Ischemia\/Reperfusion Injury through Inhibiting MMP-9 and Alleviating Loss of ZO-1 and Occludin Proteins in Mice","volume":"302","author":"Li","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/jn\/138.10.1835","article-title":"Vitamin A Deficiency and Clinical Disease: An Historical Overview","volume":"138","author":"Sommer","year":"2008","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0148607111413772","article-title":"Gut Microbiota, Intestinal Permeability, Obesity-Induced Inflammation, and Liver Injury","volume":"35","author":"Frazier","year":"2011","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature13793","article-title":"Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota","volume":"514","author":"Suez","year":"2014","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An Obesity-Associated Gut Microbiome with Increased Capacity for Energy Harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial Ecology: Human Gut Microbes Associated with Obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-Talk between Akkermansia Muciniphila and Intestinal Epithelium Controls Diet-Induced Obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet\u2013Induced Obesity and Diabetes in Mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e00434","DOI":"10.1002\/mbo3.434","article-title":"The Gastrointestinal Tract of Farmed Mink (Neovison Vison) Maintains a Diverse Mucosa-Associated Microbiota Following a 3-Day Fasting Period","volume":"6","author":"Bahl","year":"2017","journal-title":"Microbiol. Open"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1292\/jvms.16-0472","article-title":"Comparison of Fecal Microbiota of Three Captive Carnivore Species Inhabiting Korea","volume":"79","author":"An","year":"2017","journal-title":"J. Vet. Med. Sci."},{"key":"ref_71","first-page":"142","article-title":"Assessment of Fecal Microbiota in Farmed Silver Fox (Vulpes Vulpes Fulva) and Raccoon Dog (Nyctereutes Procyonoides)","volume":"68","author":"Peng","year":"2018","journal-title":"Acta Agric. Scand. Sect. A Anim. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Peng, Y., Shi, Q., Wang, Y., Zhang, F., Ji, Z., and Zhang, J. (2019). Dietary Probiotics Have Different Effects on the Composition of Fecal Microbiota in Farmed Raccoon Dog (Nyctereutes Procyonoides) and Silver Fox (Vulpes Vulpes Fulva). BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1491-x"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/13102818.2020.1835536","article-title":"Diversification of Animal Gut Microbes and NRPS Gene Clusters in Some Carnivores, Herbivores and Omnivores","volume":"34","author":"Guo","year":"2020","journal-title":"Biotechnol. Biotec. Equip."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fmicb.2019.00268","article-title":"TLR4 May Be Involved in the Regulation of Colonic Mucosal Microbiota by Vitamin A","volume":"10","author":"Xiao","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Mariat, D., Firmesse, O., Levenez, F., Guimar\u0103es, V., Sokol, H., Dor\u00e9, J., Corthier, G., and Furet, J.-P. (2009). The Firmicutes\/Bacteroidetes Ratio of the Human Microbiota Changes with Age. BMC Microbiol., 9.","DOI":"10.1186\/1471-2180-9-123"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the Microbiota in Immunity and Inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41387-019-0097-6","article-title":"The Flavonoid-Rich Quzhou Fructus Aurantii Extract Modulates Gut Microbiota and Prevents Obesity in High-Fat Diet-Fed Mice","volume":"9","author":"Bai","year":"2019","journal-title":"Nutr. Diabetes"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49081-5","article-title":"Expression of Immune Regulatory Genes Correlate with the Abundance of Specific Clostridiales and Verrucomicrobia Species in the Equine Ileum and Cecum","volume":"9","author":"Lindenberg","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3389\/fmicb.2017.01221","article-title":"The Gut Microbiota of Healthy Chilean Subjects Reveals a High Abundance of the Phylum Verrucomicrobia","volume":"8","author":"Vasquez","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia Muciniphila and Improved Metabolic Health during a Dietary Intervention in Obesity: Relationship with Gut Microbiome Richness and Ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/19490976.2017.1353842","article-title":"New Perspectives Regarding the Antiviral Effect of Vitamin A on Norovirus Using Modulation of Gut Microbiota","volume":"8","author":"Lee","year":"2017","journal-title":"Gut Microbes."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40168-017-0312-4","article-title":"Statin Therapy Causes Gut Dysbiosis in Mice through a PXR-Dependent Mechanism","volume":"5","author":"Lareu","year":"2017","journal-title":"Microbiome"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/oby.2011.111","article-title":"Responses of Gut Microbiota to Diet Composition and Weight Loss in Lean and Obese Mice","volume":"20","author":"Ravussin","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41396-019-0364-5","article-title":"Defining the Role of Parasutterella, a Previously Uncharacterized Member of the Core Gut Microbiota","volume":"13","author":"Ju","year":"2019","journal-title":"ISME J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1111\/1365-2656.13327","article-title":"The Potential Role of the Gut Microbiota in Shaping Host Energetics and Metabolic Rate","volume":"89","author":"Lindsay","year":"2020","journal-title":"J. Anim. Ecol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.2527\/jas2017.1810","article-title":"Effects of sources and concentrations of zinc on growth performance, nutrient digestibility, and fur quality of growing\u2013furring female mink (Mustela vison)","volume":"95","author":"Cui","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"s4","DOI":"10.5604\/01.3001.0010.5493","article-title":"Bile Acid Physiology","volume":"16","author":"Garruti","year":"2017","journal-title":"Ann. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"564160","DOI":"10.3389\/fmicb.2020.564160","article-title":"High-Fat Diets Led to OTU-Level Shifts in Fecal Samples of Healthy Adult Dogs","volume":"11","author":"Kilburn","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-016-0181-2","article-title":"Genomic Characterization of the Uncultured Bacteroidales Family S24-7 Inhabiting the Guts of Homeothermic Animals","volume":"4","author":"Ormerod","year":"2016","journal-title":"Microbiome"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40168-019-0637-2","article-title":"Sequence and Cultivation Study of Muribaculaceae Reveals Novel Species, Host Preference, and Functional Potential of This yet Undescribed Family","volume":"7","author":"Lagkouvardos","year":"2019","journal-title":"Microbiome"},{"key":"ref_91","unstructured":"Opdahl, L. (2017). Identification of Candidate Cellulose Utilizing Bacteria from the Rumen of Beef Cattle, Using Bacterial Community Profiling and Metagenomics. [Master\u2019s Thesis, South Dakota State University]."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrmicro2746","article-title":"How Glycan Metabolism Shapes the Human Gut Microbiota","volume":"10","author":"Koropatkin","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1038\/s41467-020-18928-1","article-title":"Rational Design of a Microbial Consortium of Mucosal Sugar Utilizers Reduces Clostridiodes Difficile Colonization","volume":"11","author":"Pereira","year":"2020","journal-title":"Nat. Commun."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/6\/1577\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:09:28Z","timestamp":1760162968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/6\/1577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":93,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ani11061577"],"URL":"https:\/\/doi.org\/10.3390\/ani11061577","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]}}}