{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:05:41Z","timestamp":1768784741527,"version":"3.49.0"},"reference-count":81,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Goji berry shows a wide range of beneficial properties in human health, but only a few studies evaluated its effects in livestock animals. The objective of this research was to assess the effects of goji berry supplementation on the hormonal profile, productive, and reproductive performance of does. Two months before artificial insemination, 105 nulliparous does were randomly divided into three groups (n = 35) based on the dietary treatment: commercial diet (C), or a diet supplemented with either 1% (G1), or 3% (G3) of goji berry, respectively. The results showed that receptivity was higher in G1 than in the C group (p &lt; 0.05). Trends toward significance for differences between the G1 and G3 groups in marginal means of LH concentrations (p = 0.059), and between G1 and C in LH AUC values (p = 0.078), were evidenced. Estrogen concentrations showed a more fluctuating trend but a significant interaction effect (p &lt; 0.001). The G1 group showed higher litter weight than C at birth (p = 0.008) and weaning (p &lt; 0.001), as well as higher litter size at weaning (p = 0.020). The G1 group also exhibited the highest mean milk production (p &lt; 0.01). In conclusion, goji berry influenced reproductive and productive performance, probably via modulating hormonal patterns and milk production in rabbits. However, further studies are needed to validate these preliminary results.<\/jats:p>","DOI":"10.3390\/ani11061672","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T21:03:32Z","timestamp":1622754212000},"page":"1672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does"],"prefix":"10.3390","volume":"11","author":[{"given":"Egon","family":"Andoni","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Albania, 1029 Kamez, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-0036","authenticated-orcid":false,"given":"Giulio","family":"Curone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Agradi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-4610","authenticated-orcid":false,"given":"Olimpia","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7970","authenticated-orcid":false,"given":"Laura","family":"Menchetti","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, University of Bologna, 40137 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-4992","authenticated-orcid":false,"given":"Daniele","family":"Vigo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-3539","authenticated-orcid":false,"given":"Riccardo","family":"Zelli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-3332","authenticated-orcid":false,"given":"Elisa","family":"Cotozzolo","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, University of Perugia, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-4890","authenticated-orcid":false,"given":"Maria Rachele","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Faustini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alda","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-757X","authenticated-orcid":false,"given":"Marta","family":"Castrica","sequence":"additional","affiliation":[{"name":"Department of Health, Animal Science and Food Safety \u201cCarlo Cantoni\u201d, University of Milano, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Brecchia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tian, X., Liang, T., Liu, Y., Ding, G., Zhang, F., and Ma, Z. (2019). Extraction, structural characterization, and biological functions of lycium barbarum polysaccharides: A review. Biomolecules, 9.","DOI":"10.3390\/biom9090389"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.14336\/AD.2017.0725","article-title":"Lycium barbarum: A traditional Chinese herb and a promising anti-aging agent","volume":"8","author":"Gao","year":"2017","journal-title":"Aging Dis."},{"key":"ref_3","first-page":"1","article-title":"Goji Berries as a potential natural antioxidant medicine: An insight into their molecular mechanisms of action","volume":"2019","author":"Ma","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109559","DOI":"10.1016\/j.biopha.2019.109559","article-title":"Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition","volume":"121","author":"Zhao","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.foodchem.2018.01.176","article-title":"Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review","volume":"254","author":"Masci","year":"2018","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.jbiotec.2016.05.114","article-title":"Effect of Lycium barbarum berries cultivated in Umbria (Italy) on human hepatocellular carcinoma cells","volume":"231","author":"Ceccarini","year":"2016","journal-title":"J. Biotechnol."},{"key":"ref_7","first-page":"1157","article-title":"Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum","volume":"17","author":"Yu","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12017-016-8393-y","article-title":"Neuro-protective Mechanisms of Lycium barbarum","volume":"18","author":"Xing","year":"2016","journal-title":"NeuroMolecular Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12944-016-0351-z","article-title":"Acid sphingomyelinase as target of Lycium Chinense: Promising new action for cell health","volume":"15","author":"Ceccarini","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.2147\/IJN.S136820","article-title":"Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice","volume":"12","author":"Bo","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ijbiomac.2020.10.037","article-title":"Gastroprotective effect of Lycium barbarum polysaccharides and C-phyocyanin in rats with ethanol-induced gastric ulcer","volume":"165","author":"Lian","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1039\/b9pp00177h","article-title":"Mice drinking goji berry juice (Lycium barbarum) are protected from UV radiation-induced skin damage via antioxidant pathways","volume":"9","author":"Reeve","year":"2010","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.4103\/1673-5374.274349","article-title":"Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury","volume":"15","author":"Liu","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.foodres.2011.03.027","article-title":"A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji)","volume":"44","author":"Amagase","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kwok, S.S., Bu, Y., Lo, A.C.Y., Chan, T.C.Y., So, K.F., Lai, J.S.M., and Shih, K.C. (2019). A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease. Biomed Res. Int., 4615745.","DOI":"10.1155\/2019\/4615745"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.foodchem.2012.10.005","article-title":"Recently introduced foods as new allergenic sources: Sensitisation to Goji berries (Lycium barbarum)","volume":"137","author":"Ferrer","year":"2013","journal-title":"Food Chem."},{"key":"ref_17","first-page":"36","article-title":"Physico-chemical properties, fatty acid composition and mineral contents of goji berry (Lycium barbarum L.) fruit","volume":"21","author":"Endes","year":"2015","journal-title":"J. Agroaliment. Process. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.foodchem.2009.10.005","article-title":"Isolation of carotenoids, flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity","volume":"120","author":"Wang","year":"2010","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0202929","article-title":"Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice","volume":"13","author":"Filipescu","year":"2018","journal-title":"PLoS ONE"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.psj.2019.10.043","article-title":"Effects of dietary Lycium barbarum polysaccharides on growth performance, digestive enzyme activities, antioxidant status, and immunity of broiler chickens","volume":"99","author":"Long","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108018","DOI":"10.1016\/j.meatsci.2019.108018","article-title":"The effect of Goji berries (Lycium barbarum) dietary supplementation on rabbit meat quality","volume":"161","author":"Menchetti","year":"2020","journal-title":"Meat. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Menchetti, L., Curone, G., Andoni, E., Barbato, O., Troisi, A., Fioretti, B., Polisca, A., Codini, M., Canali, C., and Vigo, D. (2020). Impact of goji berries (Lycium barbarum) supplementation on the energy homeostasis of rabbit does: Uni- and multivariate approach. Animals, 10.","DOI":"10.3390\/ani10112000"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Castrica, M., Menchetti, L., Balzaretti, C.C.M., Branciari, R., Ranucci, D., Cotozzolo, E., Vigo, D., Curone, G., Brecchia, G., and Miraglia, D. (2020). Impact of dietary supplementation with goji berries (Lycium barbarum) on microbiological quality, physico-chemical, and sensory characteristics of rabbit meat. Foods, 9.","DOI":"10.3390\/foods9101480"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S1357729800090111","article-title":"Metabolic adaptation and hormonal regulation in young rabbit does during long-term caloric restriction and subsequent compensatory growth","volume":"79","author":"Rommers","year":"2004","journal-title":"Anim. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1017\/S1751731111002643","article-title":"Effects of feeding programme on the performance and energy balance of nulliparous rabbit does","volume":"6","author":"Cervera","year":"2012","journal-title":"Animal"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rvsc.2014.11.017","article-title":"Food restriction during pregnancy in rabbits: Effects on hormones and metabolites involved in energy homeostasis and metabolic programming","volume":"98","author":"Menchetti","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"106505","DOI":"10.1016\/j.anireprosci.2020.106505","article-title":"Energy homeostasis in rabbit does during pregnancy and pseudopregnancy","volume":"218","author":"Menchetti","year":"2020","journal-title":"Anim. Reprod. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.theriogenology.2017.10.046","article-title":"Effects of local lipopolysaccharide administration on the expression of Toll-like receptor 4 and pro-inflammatory cytokines in uterus and oviduct of rabbit does","volume":"107","author":"Menchetti","year":"2018","journal-title":"Theriogenology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0093-691X(99)00204-6","article-title":"Effects of induced endometritis on the life-span of corpora lutea in pseudopregnant rabbits and incidence of spontaneous uterine infections related to fertility of breeding does","volume":"52","author":"Boiti","year":"1999","journal-title":"Theriogenology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1095\/biolreprod.111.092718","article-title":"Toll-Like Receptor 4 and MYD88-Dependent Signaling Mechanisms of the Innate Immune System Are Essential for the Response to Lipopolysaccharide by Epithelial and Stromal Cells of the Bovine Endometrium1","volume":"86","author":"Cronin","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.anireprosci.2014.04.009","article-title":"Effects of a bacterial lipopolysaccharide on the reproductive functions of rabbit does","volume":"147","author":"Brecchia","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.anireprosci.2009.06.016","article-title":"Short- and long-term effects of lipopolysaccharide-induced inflammation on rabbit sperm quality","volume":"118","author":"Brecchia","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3382\/ps\/pey539","article-title":"The application of antibiotics in broiler production and the resulting antibiotic resistance in Escherichia coli: A global overview","volume":"98","author":"Roth","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3168\/jds.2019-16778","article-title":"Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems","volume":"103","author":"Oliver","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_35","first-page":"112","article-title":"Zoonoses, antimicrobial resistance and food-borne outbreaks guidance for reporting 2020 data","volume":"18","author":"Amore","year":"2021","journal-title":"EFSA Support. Publ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4327470","DOI":"10.1155\/2020\/4327470","article-title":"Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck","volume":"2020","author":"Menchetti","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_37","first-page":"e220118","article-title":"Nutraceutical in male reproduction","volume":"40","author":"Freitas","year":"2018","journal-title":"Rev. Bras. Med. Vet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e13554","DOI":"10.1111\/and.13554","article-title":"Lycium barbarum polysaccharide protects against ethanol-induced spermiotoxicity and testicular degenera-tion in Immp2l(+\/-) mice","volume":"52","author":"Liu","year":"2020","journal-title":"Andrologia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.theriogenology.2019.02.011","article-title":"Lycium barbarum and Laminaria japonica polysaccharides improve Cashmere goat sperm quality and fertility rate after cryopreservation","volume":"129","author":"Ren","year":"2019","journal-title":"Theriogenology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.theriogenology.2020.01.048","article-title":"Reparative effects of lycium barbarum polysaccharide on mouse ovarian injuries induced by repeated superovulation","volume":"145","author":"Liu","year":"2020","journal-title":"Theriogenology"},{"key":"ref_41","first-page":"1915","article-title":"Discussion of protective mechanism of Lyceum barbarum polysaccharides on ovarian tissue in female senile rats","volume":"34","author":"Wei","year":"2011","journal-title":"Zhong Yao Cai"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.theriogenology.2009.09.019","article-title":"Doppler evaluation of maternal and fetal vessels during normal gestation in rabbits","volume":"73","author":"Polisca","year":"2010","journal-title":"Theriogenology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1530\/rep.1.00083","article-title":"Expression patterns of cytokines, p53 and nitric oxide synthase isoenzymes in corpora lutea of pseudopregnant rabbits during spontaneous luteolysis","volume":"127","author":"Boiti","year":"2004","journal-title":"Reproduction"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.anireprosci.2013.02.001","article-title":"Aglepristone (RU534) effects on luteal function of pseudopregnant rabbits: Steroid receptors, enzymatic activities, and hormone productions in corpus luteum and uterus","volume":"138","author":"Parillo","year":"2013","journal-title":"Anim. Reprod. Sci."},{"key":"ref_45","first-page":"60","article-title":"Prediction of the apparent digestible energy content of commercial pelleted feeds for rabbits","volume":"11","author":"Maertens","year":"1988","journal-title":"J. Appl. Rabbit. Res."},{"key":"ref_46","unstructured":"IRRG, Theau-Cl\u00e9ment, M., Maertens, L., Castellini, C., Besenfelder, U., and Boiti, C. (2005). Recommendations and guidelines for applied reproduction trials with rabbit does. World Rabbit Sci., 13, 147\u2013164."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.livsci.2018.12.016","article-title":"Effects of Goji berries supplementation on the productive performance of rabbit","volume":"220","author":"Menchetti","year":"2019","journal-title":"Livest. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.rvsc.2018.01.024","article-title":"The different effects of linseed and fish oil supplemented diets on insulin sensitivity of rabbit does during pregnancy","volume":"118","author":"Menchetti","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.domaniend.2005.09.006","article-title":"Hormonal and metabolic adaptation to fasting: Effects on the hypothalamic-pituitary-ovarian axis and reproductive performance of rabbit does","volume":"31","author":"Brecchia","year":"2006","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/rda.13846","article-title":"Effect of aglepristone (RU534) administration during follicular phase on progesterone, estradiol-17\u03b2 and LH serum concentrations in bitches","volume":"55","author":"Troisi","year":"2020","journal-title":"Reprod. Domest. Anim."},{"key":"ref_51","first-page":"159","article-title":"Comportement d\u2019oestrus chez la lapine","volume":"33","author":"Moret","year":"1980","journal-title":"Cunicult. Mag."},{"key":"ref_52","unstructured":"Rodriguez, J.M., and Ubilla, E. (1988, January 10\u201314). Effects of sexual receptivity on ovulation response in rabbit does induced with GnRH. Proceedings of the Proc 4th World Rabbit Congress, Buadapest, Hungary."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1530\/jrf.0.0820209","article-title":"Relation between circulating sex steroid concentrations and sexual behaviour during pregnancy and post-partum in the domestic rabbit","volume":"82","author":"Stouflet","year":"1988","journal-title":"J. Reprod. Fertil."},{"key":"ref_54","first-page":"13","article-title":"Effect of degree of sexual receptivity on post-partum plasma estardiol and ovulatory response in rabbit","volume":"43","author":"Rebollar","year":"1992","journal-title":"Rev. Esp. Fisiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/jrf.0.0690179","article-title":"Oestrous behaviour and circulating progesterone and oestrogen levels during pseudo-pregnancy in the domestic rabbit","volume":"69","author":"Caillol","year":"1983","journal-title":"J. Reprod. Fertil."},{"key":"ref_56","first-page":"412","article-title":"A study on relationship between receptivity and lactation in the doe, and their influ-ence on reproductive performance","volume":"15","author":"Roustan","year":"1992","journal-title":"J. Appl. Rabbit. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1620\/tjem.106.219","article-title":"A Lycium Chinense Miller Component Inducing Ovulation in Adult Female Rabbits","volume":"106","author":"Suzuki","year":"1972","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1095\/biolreprod35.4.1009","article-title":"Feedback effects of ovarian steroids on the hypothalamic-hypophyseal axis in the rab-bit","volume":"35","author":"Pau","year":"1986","journal-title":"Biol. Reprod."},{"key":"ref_59","unstructured":"Knobil, E., and Neill, J.D. (1994). The neuroendocrine control of the rabbit ovarian cycle. The Physiology of Reproduction, Raven Press. [2nd ed.]."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.theriogenology.2011.07.041","article-title":"Ovulating induction methods in rabbit does: The pituitary and ovarian responses","volume":"77","author":"Rebollar","year":"2012","journal-title":"Theriogenology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Jones, E.E., Bain, J.B., and Odell, W.D. (1976). Postcoital luteinizing hormone release in male and female rabbits as determined by ra-dioimmunoassay. Fertil. Steril., 848\u2013852.","DOI":"10.1016\/S0015-0282(16)41962-X"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"690808","DOI":"10.1155\/2013\/690808","article-title":"Protective effects of lycium barbarum polysaccharides on testis spermatogenic injury induced by bisphenol a in mice","volume":"2013","author":"Zhang","year":"2013","journal-title":"Evidence Based Complement. Altern. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1507\/endocrj.EJ16-0430","article-title":"Protective effects of lycium barbarum polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice","volume":"64","author":"Shi","year":"2017","journal-title":"Endocr. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.lfs.2006.02.012","article-title":"Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats","volume":"79","author":"Luo","year":"2006","journal-title":"Life Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/asj.13295","article-title":"Semen quality improvement in boars fed with supplemental wolfberry (Lycium barbarum)","volume":"90","author":"Yang","year":"2019","journal-title":"Anim. Sci. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3168\/jds.S0022-0302(06)72192-0","article-title":"Major advances associated with the biosynthesis of milk","volume":"89","author":"Bauman","year":"2006","journal-title":"J. Dairy Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, Y., Wang, M., Zhou, G., Chen, L., Ding, L., Bu, D., and Loor, J. (2020). Arginine supply impacts the expression of candidate microRNA controlling milk casein yield in Bovine mammary tissue. Animals, 10.","DOI":"10.3390\/ani10050797"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S2095-3119(16)61426-0","article-title":"Dietary arginine supplementation in multiparous sows during lactation improves the weight gain of suckling piglets","volume":"16","author":"Zhu","year":"2017","journal-title":"J. Integr. Agric."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jcb.20825","article-title":"Role of amino acids in translational mechanisms governing milk protein synthesis in murine and ruminant mammary epithelial cells","volume":"98","author":"Moshel","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0029-1186218","article-title":"Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity","volume":"76","author":"Potterat","year":"2010","journal-title":"Planta Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2527\/1999.772416x","article-title":"Effect of postweaning feeding on the performance and energy balance of female rabbits at different physiological states","volume":"77","author":"Xiccato","year":"1999","journal-title":"J. Anim. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.domaniend.2005.03.006","article-title":"Endocrinology of milk production","volume":"29","author":"Olsson","year":"2005","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4995\/wrs.2010.18.10","article-title":"Milk production of pseudopregnant multiparous does","volume":"18","author":"Matics","year":"2010","journal-title":"World Rabbit Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"112525","DOI":"10.1016\/j.jep.2019.112525","article-title":"A combination of Semen Cuscutae and Fructus Lycii improves testicular cell proliferation and inhibits their apoptosis in rats with spermatogenic dysfunction by regulating the SCF\/c-kit--PI3K--Bcl-2 pathway","volume":"251","author":"Guan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hashem, N.M., Gonzalez-Bulnes, A., and Simal-Gandara, J. (2020). Polyphenols in farm animals: Source of reproductive gain or waste?. Antioxidants, 9.","DOI":"10.3390\/antiox9101023"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/jpn.13247","article-title":"Effects of dietary supplementation of Lycium barbarum polysaccharides on growth performance, immune status, antioxidant capacity and selected microbial populations of weaned piglets","volume":"104","author":"Chen","year":"2020","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.fsi.2019.02.016","article-title":"The effects of dietary Lycium barbarum extract on growth performance, liver health and immune related genes expression in hybrid grouper (Epinephelus lanceolatus\u2642 \u00d7 E. fuscoguttatus\u2640) fed high lipid diets","volume":"87","author":"Tan","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jff.2017.03.053","article-title":"Polysaccharide from Lycium barbarum L. leaves enhances absorption of endogenous calcium, and elevates cecal calcium transport protein levels and serum cytokine levels in rats","volume":"33","author":"Ren","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"109591","DOI":"10.1016\/j.biopha.2019.109591","article-title":"Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide","volume":"121","author":"Zhu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1039\/C8FO02565G","article-title":"Supplementation with compound polysaccharides contributes to the development and metabolic activity of young rat intestinal microbiota","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1039\/C8FO01946K","article-title":"The impacts of natural polysaccharides on intestinal microbiota and immune responses-a review","volume":"10","author":"Tang","year":"2019","journal-title":"Food Funct."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/6\/1672\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:10:41Z","timestamp":1760163041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/6\/1672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":81,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["ani11061672"],"URL":"https:\/\/doi.org\/10.3390\/ani11061672","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]}}}