{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:40Z","timestamp":1787027560060,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study aimed to investigate the dynamic change of adrenocorticotrophic hormone (ACTH), cortisol, leptin, mitochondrial uncoupling protein 1 (UCP1), lipids and lipoproteins in mares during late pregnancy and the postpartum period. A total of 20 mares (10 pregnant mares, monitored from 14 \u00b1 2 days before expected foaling until 14 days after foaling, Group A; 10 non-pregnant and non-lactating mares, Group B) were enrolled in the study. Body Condition Score (BCS) and body weight (BW) values were recorded from each animal. In Group A, blood samples were collected on days 14 \u00b1 2 and 7 \u00b1 2 before foaling (T\u221214; T\u22127), and on days 7 and 14 after foaling (T+7; T+14). From mares of Group B, blood samples were collected at the beginning of the study. The levels of ACTH, cortisol, leptin, UCP1, non-esterified fatty acids (NEFAs), total cholesterol, high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), triglycerides and very-low-density lipoproteins (VLDLs) were investigated. While BCS showed no statistical change throughout the monitoring period (p &gt; 0.05), all the other studied parameters displayed statistically significant variations in Group A over the peripartum period (p &lt; 0.0001). A significant effect of pregnancy was found on all studied parameters (p &lt; 0.001). The ACTH and cortisol levels measured in mares belonged to Group A showed a significant positive correlation with the values of leptin, LDLs, triglycerides and VLDLs, whereas they were negatively correlated with the serum UCP1 and NEFAs values. Together, the findings gathered in this study highlight a dynamic change of serum leptin, UCP1 and lipid parameters in peripartum mares and suggest an interaction of the HPA axis with lipid metabolism and mobilization in mares during the peripartum period in order to deal with metabolic and energy demand and maintain energy homeostasis.<\/jats:p>","DOI":"10.3390\/ani11072051","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T10:50:38Z","timestamp":1625827838000},"page":"2051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Physiological Correlation between Hypothalamic\u2013Pituitary\u2013Adrenal Axis, Leptin, UCP1 and Lipid Panel in Mares during Late Pregnancy and Early Postpartum Period"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-2691","authenticated-orcid":false,"given":"Francesca","family":"Arfuso","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Polo Universitario dell\u2019Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-1181","authenticated-orcid":false,"given":"Claudia","family":"Giannetto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Polo Universitario dell\u2019Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Bazzano","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Andrea D\u2019Accorso, 16, 62032 Macerata, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Assenza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Polo Universitario dell\u2019Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4736-1087","authenticated-orcid":false,"given":"Giuseppe","family":"Piccione","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Polo Universitario dell\u2019Annunziata, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"ref_1","unstructured":"Knottenbelt, D.C., Holdstock, N., and Madigan, J.E. 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