{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:42:42Z","timestamp":1772678562573,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Tooth resorption (TR; progressive destruction of hard dental tissues) varies in prevalence according to population, age, and country (29\u201366.1%). Our objective was twofold: describing the TR clinical presentation in Northeastern Spain, and studying 34 blood parameters to ascertain potential systemic effects associated with TR. Cases (29; presented from September 2018 to May 2019) and controls (58) were considered. Non-parametric tests were carried out to compare cases and controls for each blood parameter; those showing significant differences were chosen for multiple regression analysis (binomial logistic and hierarchical multiple regressions). In case TR was detected in 130\/870 teeth (14.9%), TR stage and type were correlated (p &lt; 0.001). Increasing CREA values (p = 0.034) and decreasing BUN\/CREA and ALB\/GLOB values were associated with TR presence (p = 0.029 and p = 0.03, respectively). Increasing GLOB was associated with increasing severity of TR (p &lt; 0.01). Type 1 TR (highly related to inflammation and periodontal disease PD) was the most frequently observed type; the association of TR and inflammation biomarkers (ALB\/GLOB, GLOB) are explained by this fact. The concomitant presence of PD and TR in old cats would cause TR association with kidney damage biomarkers (CREA, BUN\/CREA). When affected by TR, special care in these aspects must be provided to cats.<\/jats:p>","DOI":"10.3390\/ani11072125","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:16:48Z","timestamp":1626643008000},"page":"2125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood Parameters and Feline Tooth Resorption: A Retrospective Case Control Study from a Spanish University Hospital"],"prefix":"10.3390","volume":"11","author":[{"given":"Ana","family":"Whyte","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, Faculty of Veterinary Medicine, University of Zaragoza, C\/Miguel Servet 177, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-5144","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Tejedor","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embryology and Animal Genetics, Faculty of Veterinary Medicine, University of Zaragoza, C\/Miguel Servet 177, 50013 Zaragoza, Spain"},{"name":"CIBER CV (University of Zaragoza\u2014IIS), Faculty of Veterinary Medicine, University of Zaragoza, C\/Miguel Servet 177, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Whyte","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, C\/Domingo Miral, s\/n, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0210-2919","authenticated-orcid":false,"given":"Luis Vicente","family":"Monteagudo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embryology and Animal Genetics, Faculty of Veterinary Medicine, University of Zaragoza, C\/Miguel Servet 177, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-9891","authenticated-orcid":false,"given":"Cristina","family":"Bonastre","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Faculty of Veterinary Medicine, University of Zaragoza, C\/Miguel Servet 177, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5326\/JAAHA-MS-4013","article-title":"AAHA dental care guidelines for dogs and cats","volume":"49","author":"Holmstrom","year":"2013","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/089875641303000202","article-title":"Risk assessment of feline tooth resorption: A Portuguese clinical case control study","volume":"30","author":"Mestrinho","year":"2013","journal-title":"J. Vet. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1748-5827.2001.tb02497.x","article-title":"Prevalence of odontoclastic resorptive lesions in a clinically healthy cat population","volume":"42","author":"Ingham","year":"2001","journal-title":"J. Small Anim. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1998.212.03.392","article-title":"Prevalence and risk factors for odontoclastic resorptive lesions in cats","volume":"212","author":"Lund","year":"1998","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.2460\/javma.2000.217.1866","article-title":"Prevalence of odontoclastic resorption lesions and periapical radiographic lucencies in cats: 265 cases (1995\u20131998)","volume":"217","author":"Lommer","year":"2000","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100369","DOI":"10.1016\/j.tcam.2019.100369","article-title":"Tooth resorption in Spanish domestic cats: Preliminary Data","volume":"38","author":"Whyte","year":"2020","journal-title":"Top. Companion Anim. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0195-5616(92)50133-4","article-title":"Etiopathogenesis of feline dental resorptive lesions","volume":"22","author":"Okuda","year":"1992","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.vetimm.2009.05.015","article-title":"Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats","volume":"132","author":"Tryfonidou","year":"2009","journal-title":"Vet. Immunol. Immunop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/089875640902600301","article-title":"Periodontal health status in a colony of 109 cats","volume":"26","author":"Girard","year":"2009","journal-title":"J. Vet. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1748-5827.2002.tb00018.x","article-title":"Feline odontoclastic resorptive lesions: Unveiling the early lesion","volume":"43","author":"Gorrel","year":"2002","journal-title":"J. Small Anim. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-9657.1989.tb00354.x","article-title":"Dynamics of dento alveolar ankylosis and associated root resorption","volume":"5","author":"Lindskog","year":"1989","journal-title":"Endod. Dent. Traumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0195-5616(02)00027-X","article-title":"Feline odontoclastic resorptive lesions. An unsolved enigma in veterinary dentistry","volume":"32","author":"Reiter","year":"2002","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_13","unstructured":"Harvey, C.E. (1993). Restorative Dentistry. Small Animal Dentistry, Mosby-Year Book."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/089875640402100102","article-title":"Mapping of the radiographic central point of feline dental resorptive lesions","volume":"21","author":"Harvey","year":"2004","journal-title":"J. Vet. Dent."},{"key":"ref_15","first-page":"39","article-title":"Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats","volume":"1","author":"Ferbus","year":"2010","journal-title":"Eur. J. Oral Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2460\/ajvr.2005.66.1446","article-title":"Evaluation of calciotropic hormones in cats with odontoclastic resorptive lesions","volume":"66","author":"Reiter","year":"2005","journal-title":"Am. J. Vet. Res"},{"key":"ref_17","first-page":"57","article-title":"Epidemiology in practice: Case-control studies","volume":"11","author":"Lewallen","year":"1998","journal-title":"Community Eye Health"},{"key":"ref_18","unstructured":"Real Decreto 53\/2013 (RD 53\/2013) de 8 de Febrero (2013). Relativo a las normas b\u00e1sicas aplicables para la protecci\u00f3n de los animales utilizados en experimentaci\u00f3n y otros fines cient\u00edficos, incluyendo la docencia. BOE, 34, 11370\u201311421. Available online: https:\/\/www.boe.es\/eli\/es\/rd\/2013\/02\/01\/53."},{"key":"ref_19","first-page":"43","article-title":"AAFP-AAHA: Feline life stage guidelines","volume":"12","author":"Rodan","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"ref_20","unstructured":"American Veterinary Dental College (AVDC) (2021, May 30). Recommendations. Available online: https:\/\/avdc.org\/avdc-nomenclature."},{"key":"ref_21","unstructured":"(2021, May 30). Power Calculator Correlation. Available online: https:\/\/sample-size.net\/correlation-sample-size\/."},{"key":"ref_22","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Psychology Press. [2nd ed.]."},{"key":"ref_23","unstructured":"(2021, May 30). Sample Size Calculator. Available online: http:\/\/sampsize.sourceforge.net\/iface\/index.html."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/03610911003650383","article-title":"How Big is a big odds ratio? Interpreting the magnitudes of odds ratios in epidemiological studies","volume":"39","author":"Chen","year":"2010","journal-title":"Commun. Stat. Simul."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1748-5827.2004.tb00181.x","article-title":"A rapid screening technique for feline odontoclastic resorptive lesions","volume":"45","author":"Heaton","year":"2004","journal-title":"J. Small Anim. Pract."},{"key":"ref_26","unstructured":"Niemiec, B.A. (2012). Feline tooth resorption. Today\u2019s Vet. Pract., 59\u201363. Available online: https:\/\/todaysveterinarypractice.com\/wp-content\/uploads\/sites\/4\/2016\/06\/T1209C04.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0195-5616(92)50134-6","article-title":"Feline dental resorptive lesions, prevalence patterns","volume":"22","author":"Harvey","year":"1992","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_28","unstructured":"Jenkins, E.J. (2019). Tooth Resorption and Risk for Anesthetic Complication during Anesthetized Dental Procedures in Domestic Felines. [Master\u2019s Thesis, University of Maryland]. Available online: https:\/\/drum.lib.umd.edu\/handle\/1903\/22027."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/1098612X14560098","article-title":"Tooth resorption in cats. Pathophysiology and treatment options","volume":"17","author":"Gorrel","year":"2015","journal-title":"J. Feline Med. Surg."},{"key":"ref_30","first-page":"3","article-title":"Survey of feline dental problems encountered in a small animal practice in NW England","volume":"2","author":"Crossley","year":"1991","journal-title":"Br. Vet. Dent. Assoc. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1098612X16649525","article-title":"Evaluating aging in cats. How to determine what is healthy and what is disease","volume":"18","author":"Bellows","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ansar, W., and Ghosh, S. (2016). Inflammation and inflammatory diseases, markers, and mediators: Role of CRP in some inflammatory diseases. Biology of C Reactive Protein in Health and Disease, Springer.","DOI":"10.1007\/978-81-322-2680-2_4"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3343\/alm.2014.34.4.263","article-title":"Update on procalcitonin measurements","volume":"34","author":"Meisner","year":"2014","journal-title":"Ann. Lab. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1515\/cclm-2018-1181","article-title":"Procalcitonin (PCT)-guided antibiotic stewardship: An international experts consensus on optimized clinical use","volume":"57","author":"Schuetz","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_36","unstructured":"Stockham, S.L., and Scott, M.A. (2008). Proteins. Fundamentals of Veterinary Clinical Pathology, Blackwell. [2nd ed.]."},{"key":"ref_37","first-page":"105","article-title":"Understanding and interpreting serum protein electrophoresis","volume":"71","author":"Horita","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rosa, R.M., and Mestrinho, L.A. (2019). Acute phase protein in cats. Cienc. Rural, 4, Available online: https:\/\/www.scielo.br\/pdf\/cr\/v49n4\/1678-4596-cr-49-04-e20180790.pdf.","DOI":"10.1590\/0103-8478cr20180790"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/01652176.2012.745957","article-title":"Systemic effects of periodontal disease in cats","volume":"32","author":"Cave","year":"2012","journal-title":"Vet. Quart."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1600-051X.1989.tb02329.x","article-title":"Serum IgG antibodies reactive with lipoteichoic acid adult patients with periodontitis","volume":"16","author":"Monefeldt","year":"1989","journal-title":"J. Clin. Periodontol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1177\/0022034510381903","article-title":"Involvement of autoimmunity in the pathogenesis of aggressive periodontitis","volume":"89","author":"Hendler","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jfms.2010.03.018","article-title":"Serum protein electrophoresis in 155 cats","volume":"12","author":"Taylor","year":"2010","journal-title":"J. Feline Med. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/(SICI)1098-2825(1999)13:6<273::AID-JCLA4>3.0.CO;2-X","article-title":"Reference distributions for the negative acute-phase serum proteins, albumin, transferrin, and transthyretin: A practical, simple and clinically relevant approach in a large cohort","volume":"13","author":"Ritchie","year":"1999","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/jicd.12127","article-title":"Changes in cellular and molecular components of peripheral blood in patients with generalized aggressive periodontitis","volume":"7","author":"Gaddale","year":"2014","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/00000441-200504000-00003","article-title":"Incidence of bacteremia, after routine tooth brushing","volume":"329","author":"Hartzell","year":"2005","journal-title":"Am. J. Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-005-0353-8","article-title":"Fc receptors and their role in immune regulation and autoimmunity","volume":"25","author":"Takai","year":"2005","journal-title":"J. Clin. Immunol."},{"key":"ref_47","unstructured":"Lobprise, H.B., and Johnathon, R. (1997). Periodontology. Veterinary Dentistry, Principals and Practice, Lippincott Raven."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.archoralbio.2009.11.004","article-title":"Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis","volume":"55","author":"Arzi","year":"2010","journal-title":"Arch Oral Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/vcp.12333","article-title":"Renal biomarkers in domestic species","volume":"45","author":"Hokamp","year":"2016","journal-title":"Vet. Clin. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2460\/javma.244.3.320","article-title":"Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals","volume":"244","author":"Greene","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1053\/j.ajkd.2004.12.009","article-title":"Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study","volume":"45","author":"Kshirsagar","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.prevetmed.2011.01.011","article-title":"Association between chronic azotemic kidney disease and the severity of periodontal disease in dogs","volume":"99","author":"Glickman","year":"2011","journal-title":"Prev. Vet. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/089875640802500210","article-title":"Periodontal disease burden and pathological changes in organs of dogs","volume":"25","author":"Pavlica","year":"2008","journal-title":"J. Vet. Dent."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/7\/2125\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:31:16Z","timestamp":1760164276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/7\/2125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,17]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["ani11072125"],"URL":"https:\/\/doi.org\/10.3390\/ani11072125","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,17]]}}}