{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:43:55Z","timestamp":1781484235243,"version":"3.54.1"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Isoquinoline alkaloids (IQ) exert beneficial antimicrobial and anti-inflammatory effects in livestock. Therefore, we hypothesized that supplementing sows\u2019 diets with IQ during gestation would decrease farrowing stress, affecting the piglets\u2019 development and performance. Sows were divided into: IQ1, supplemented with IQ from gestation day 80 (G80) to weaning; IQ2, supplemented from gestation day 110 (G110) to weaning, and a non-supplemented (NC) group. Sow body weight (BW), feed intake, back-fat thickness and back-muscle thickness were monitored. Cortisol, glucose and insulin were measured in sows\u2019 blood collected 5 d before, during, and after 7 d farrowing. Protein, fat, IgA and IgG were analyzed in the colostrum and milk. Piglets were monitored for weight and diarrhea score, and for ileum histology and gene expression 5 d post-weaning. IQ-supplemented sows lost less BW during lactation. Glucose and insulin levels were lower in the IQ groups compared to NC-sows 5 d before farrowing and had higher levels of protein and IgG in their colostrum. No other differences were observed in sows, nor in the measured parameters in piglets. In conclusion, IQ supplementation affected sows\u2019 metabolism, reducing body weight loss during lactation. Providing IQ to sows from their entrance into the maternity barn might be sufficient to induce these effects. IQ improved colostrum quality, increasing the protein and IgG content, improving passive immunity for piglets.<\/jats:p>","DOI":"10.3390\/ani11082195","type":"journal-article","created":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T22:06:21Z","timestamp":1627250781000},"page":"2195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isoquinoline Alkaloids in Sows\u2019 Diet Reduce Body Weight Loss during Lactation and Increase IgG in Colostrum"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-1510","authenticated-orcid":false,"given":"Ester","family":"Ar\u00e9valo Sureda","sequence":"first","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Artuso-Ponte","sequence":"additional","affiliation":[{"name":"Phytobiotics Futterzusatzstoffe GmbH, 65343 Eltville, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie-Charlotte","family":"Wall","sequence":"additional","affiliation":[{"name":"Phytobiotics Futterzusatzstoffe GmbH, 65343 Eltville, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Uerlings","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-7426","authenticated-orcid":false,"given":"Yuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-8141","authenticated-orcid":false,"given":"Martine","family":"Schroyen","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-485X","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Grelet","sequence":"additional","affiliation":[{"name":"Valorisation of Agricultural Products Department, Walloon Agricultural Research Centre, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-4334","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Dehareng","sequence":"additional","affiliation":[{"name":"Valorisation of Agricultural Products Department, Walloon Agricultural Research Centre, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Wavreille","sequence":"additional","affiliation":[{"name":"Production and Sectors Department, Walloon Agricultural Research Centre, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Everaert","sequence":"additional","affiliation":[{"name":"Precision Livestock and Nutrition Laboratory, TERRA Teaching and Research Centre, GeQAmbloux Agro-Bio Tech, University of Li\u00e8ge, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.fitote.2010.06.020","article-title":"Phytochemical and antimicrobial characterization of Macleaya cordata 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