{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:34:32Z","timestamp":1792553672128,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Traditionally, canine degenerative lumbosacral stenosis (DLS) has been defined as a multifactorial syndrome characterized by lumbosacral pain triggered by the compression of the nerve rootlets of the cauda equina. There is still no consensus on the treatment of this condition, probably because there are a plethora of possible causes. In addition to compression, inflammation is a very important factor in the physiopathology of the disorder. Platelet-rich plasma (PRP) consists of an increased concentration of autologous platelets suspended in a small amount of plasma. Platelets are a source of several growth factors. Growth factors were shown to help in wound healing and biological processes, such as chemotaxis, neovascularization and synthesis of extracellular matrix, and growth factors were used to improve soft tissue healing and bone regeneration. PRP also facilitates the restoration of the structural integrity of the affected anatomy. Fourteen dogs diagnosed with DLS were treated with three epidural injections of PRP on days 0, 15 and 45. All dogs showed clinical improvement 3 months after the initial treatment. Gait was also objectively assessed by means of the use of force platform analysis before and after treatment, showing significant improvement. The results show that PRP may provide a good alternative to other nonsurgical treatments, such as prednisolone epidural injection.<\/jats:p>","DOI":"10.3390\/ani11102965","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T22:42:18Z","timestamp":1634251338000},"page":"2965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Platelet-Rich Plasma for the Treatment of Degenerative Lumbosacral Stenosis: A Study with Retired Working Dogs"],"prefix":"10.3390","volume":"11","author":[{"given":"\u00c1ngel Mar\u00eda","family":"Hern\u00e1ndez-Guerra","sequence":"first","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-9745","authenticated-orcid":false,"given":"Joaqu\u00edn Jes\u00fas","family":"Sopena","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-2274","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Vilar","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Instituto Universitario de Investigaciones Biom\u00e9dicas y Universitarias, Universidad de Las Palmas de Gran Canaria, Trasmonta\u00f1a S\/N, 35416 Arucas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-4560","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-4814","authenticated-orcid":false,"given":"Angelo","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas, Universidad de Las Palmas de Gran Canaria, 35018 Las Palmas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-8862","authenticated-orcid":false,"given":"M\u00f3nica","family":"Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"ref_1","first-page":"169","article-title":"Canine Degenerative Lumbosacral Stenosis: Prevalence, Impact And Management Strategies","volume":"10","author":"Worth","year":"2019","journal-title":"Vet. 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