{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:30:02Z","timestamp":1760236202932,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Suinfort\u00ae, a commercial semen supplement demonstrated to increase fertility and litter size in commercial sows, was tested to improve reproductive performance in Iberian sows. A total of 1430 Iberian sows were artificially inseminated (AI) with semen from Duroc boars and assigned by parity to receive the seminal additive Suinfort\u00ae containing 2 IU oxytocin, 5 \u00b5g lecirelin, and 2 mM caffeine (SF; n = 1713 AI), or to serve as non-supplemented controls (CON; n = 2625 AI). CON showed a lower fertility comparing to winter for spring (p = 0.001) and summer (p &lt; 0.001); summer was lower than autumn (p = 0.012). SF removed this seasonal effect (p &gt; 0.05). Fertility was significantly higher for SF sows during summer (p = 0.025) and autumn (p = 0.004). Total born, live-born, stillborn, and mummified piglets did not differ between CON and SF but were impacted by the season, with total and live-born decreasing in summer compared with autumn (p\u00a0&lt; 0.001) and winter (p = 0.005). In conclusion, seminal supplementation with Suinfort\u00ae improved the fertility of Iberian sows during periods of seasonal infertility.<\/jats:p>","DOI":"10.3390\/ani11113176","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:41:14Z","timestamp":1636317674000},"page":"3176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Suinfort\u00ae Semen Supplement Counters Seasonal Infertility in Iberian Sows"],"prefix":"10.3390","volume":"11","author":[{"given":"Javier","family":"Pi\u00f1\u00e1n","sequence":"first","affiliation":[{"name":"Institute of Animal Health and Cattle Development (INDEGSAL), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-4302","authenticated-orcid":false,"given":"Felipe","family":"Martinez-Pastor","sequence":"additional","affiliation":[{"name":"Institute of Animal Health and Cattle Development (INDEGSAL), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"},{"name":"Department of Molecular Biology (Cell Biology), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-9886","authenticated-orcid":false,"given":"Beatriz","family":"Alegre","sequence":"additional","affiliation":[{"name":"Institute of Animal Health and Cattle Development (INDEGSAL), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"},{"name":"Department of Animal Medicine, Surgery and Anatomy (Animal Medicine and Surgery), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Maj","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, CA 93407-0255, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-8301","authenticated-orcid":false,"given":"Roy N.","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, SA 5371, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-1573","authenticated-orcid":false,"given":"Juan Carlos","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Institute of Animal Health and Cattle Development (INDEGSAL), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"},{"name":"Department of Animal Medicine, Surgery and Anatomy (Animal Medicine and Surgery), Universidad de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-1549","authenticated-orcid":false,"given":"Rodrigo","family":"Manjar\u00edn","sequence":"additional","affiliation":[{"name":"Animal Science Department, California Polytechnic State University, San Luis Obispo, CA 93407-0255, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.theriogenology.2019.05.030","article-title":"Application of Preserved Boar Semen for Artificial Insemination: Past, Present and Future Challenges","volume":"137","author":"Waberski","year":"2019","journal-title":"Theriogenology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lamb, G.C., and DiLorenzo, N. (2014). Impact of Swine Reproductive Technologies on Pig and Global Food Production. Current and Future Reproductive Technologies and World Food Production, Springer.","DOI":"10.1007\/978-1-4614-8887-3"},{"key":"ref_3","first-page":"117","article-title":"Physiological Role of Seminal Components in the Reproductive Tract of the Female Pig","volume":"40","author":"Claus","year":"1990","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-4320(98)00146-8","article-title":"Semen Backflow after Insemination and Its Effect on Fertilisation Results in Sows","volume":"54","author":"Steverink","year":"1998","journal-title":"Anim. Reprod. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1530\/rep.0.1230683","article-title":"Role of Myometrial Activity in Sperm Transport through the Genital Tract and in Fertilization in Sows","volume":"123","author":"Langendijk","year":"2002","journal-title":"Reprod. Camb. Engl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.2527\/jas.2009-1941","article-title":"Use of Frozen-Thawed Semen Aggravates the Summer-Autumn Infertility of Artificially Inseminated Weaned Sows in the Mediterranean Region","volume":"87","author":"Vazquez","year":"2009","journal-title":"J. Anim. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/vr.139.4.93","article-title":"Swine Summer Infertility Syndrome in North West Spain","volume":"139","author":"Anel","year":"1996","journal-title":"Vet. Rec."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0093-691X(98)00032-6","article-title":"Treatment of Swine Summer Infertility Syndrome by Means of Oxytocin under Field Conditions","volume":"49","author":"Carbajo","year":"1998","journal-title":"Theriogenology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1071\/RD11249","article-title":"Seasonal Variation in the Ovarian Function of Sows","volume":"24","author":"Bertoldo","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Manjar\u00edn, R., Kirkwood, R.N., Ngula, J., Martinez-Pastor, F., Alegre, B., and Dom\u00ednguez, J.C. (2019). Effect of Oxytocin, Cloprostenol or Buserelin in Semen Doses on Sow Fertility. Anim. Open Access J., 9.","DOI":"10.3390\/ani9100746"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106193","DOI":"10.1016\/j.anireprosci.2019.106193","article-title":"A Novel Semen Supplement (SuinFort) Improves Sow Fertility after Artificial Insemination","volume":"210","author":"Ngula","year":"2019","journal-title":"Anim. Reprod. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nieto, R., Garc\u00eda-Casco, J., Lara, L., Palma-Granados, P., Izquierdo, M., Hernandez, F., Dieguez, E., Duarte, J.L., and Batorek-Luka\u010d, N. (2019). Ib\u00e9rico (Iberian) Pig. European Local Pig Breeds\u2014Diversity and Performance\u2014A Study of Project TREASURE, IntechOpen.","DOI":"10.5772\/intechopen.83765"},{"key":"ref_13","first-page":"9","article-title":"Animal Breeding Scheme Applied to the Quality of Pure Iberian Montanera Pigs","volume":"1","author":"Esquiliche","year":"2018","journal-title":"Arch. Zootec."},{"key":"ref_14","first-page":"20","article-title":"Evaluation of the Hypothetic Suitability of Using Oestrogens and Oxytocin as a Semen Additive to Reduce the Time Required for the Completion of Pig Artificial Insemination","volume":"157","author":"Riol","year":"2006","journal-title":"Rev. M\u00e9d. V\u00e9t."},{"key":"ref_15","unstructured":"R Core Team (2021). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using Lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40813-016-0049-7","article-title":"Factors for Improving Reproductive Performance of Sows and Herd Productivity in Commercial Breeding Herds","volume":"3","author":"Koketsu","year":"2017","journal-title":"Porc. Health Manag."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.theriogenology.2017.04.004","article-title":"Seasonal Infertility in Gilts and Sows: Aetiology, Clinical Implications and Treatments","volume":"96","author":"Ziecik","year":"2017","journal-title":"Theriogenology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11250-020-02474-5","article-title":"Productive and Reproductive Performances of Two-Breed and Three-Breed Pig Crosses with Niang Megha, Hampshire and Duroc Inheritance Reared under Subtropical Eastern Himalayan Hilly Climate","volume":"53","author":"Kadirvel","year":"2021","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.livsci.2011.02.019","article-title":"Reproductive Performance of Second Parity Sows: Relations with Subsequent Reproduction","volume":"140","author":"Hoving","year":"2011","journal-title":"Livest. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.2527\/1993.7161400x","article-title":"Genetic and Economic Analyses of Sow Replacement Rates in the Commercial Tier of a Hierarchical Swine Breeding Structure","volume":"71","author":"Faust","year":"1993","journal-title":"J. Anim. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.theriogenology.2004.09.027","article-title":"Uterine Activity, Sperm Transport, and the Role of Boar Stimuli around Insemination in Sows","volume":"63","author":"Langendijk","year":"2005","journal-title":"Theriogenology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0093-691X(02)01157-3","article-title":"Effects of Different Sexual Stimuli on Oxytocin Release, Uterine Activity and Receptive Behavior in Estrous Sows","volume":"59","author":"Langendijk","year":"2003","journal-title":"Theriogenology"},{"key":"ref_24","first-page":"8","article-title":"Addition of Oxytocin to Semen Extender Improves Both Sperm Transport to the Oviduct and Conception Rates in Pigs Following AI","volume":"85","author":"Okazaki","year":"2014","journal-title":"Anim. Sci. J. Nihon Chikusan Gakkaiho"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2508\/chikusan.51.272","article-title":"Effect of Caffeine on Motility of Boar Spermatozoa","volume":"51","author":"Miyamoto","year":"1980","journal-title":"Nihon Chikusan Gakkaiho"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"557","DOI":"10.56808\/2985-1130.2870","article-title":"Effects of Centrifugation and Removal of Seminal Plasma on Motility of Fresh Boar Sperm","volume":"47","author":"Bury","year":"2017","journal-title":"Thai J. Vet. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.anireprosci.2004.02.005","article-title":"Factors Affecting Temporal Relationships between Estrus and Ovulation in Commercial Sow Farms","volume":"84","author":"Belstra","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.theriogenology.2017.08.021","article-title":"Design and Biological Effects of a Vaginally Administered Gel Containing the GnRH Agonist, Triptorelin, for Synchronizing Ovulation in Swine","volume":"112","author":"Knox","year":"2018","journal-title":"Theriogenology"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/11\/3176\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:26:58Z","timestamp":1760167618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/11\/3176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,6]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ani11113176"],"URL":"https:\/\/doi.org\/10.3390\/ani11113176","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2021,11,6]]}}}