{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:53:38Z","timestamp":1783968818003,"version":"3.55.0"},"reference-count":98,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["9629100"],"award-info":[{"award-number":["9629100"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study was designed to examine the potentials of telomere length, mitochondria, and acute phase protein genes as novel biomarkers of gastrointestinal (GI) tract pathologies and meat quality traits. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and records on body weight, telomere length, GI tract and muscle histopathological test, meat quality traits, mitochondria, and acute phase protein genes were obtained at weeks 4 and 6 of age. The body weight of CORT-fed chickens was significantly suppressed (p &lt; 0.05). CORT significantly altered the GI tract and meat quality traits. The interaction effect of CORT and age on body weight, duodenum and ileum crypt depth, pH, and meat color was significant (p &lt; 0.05). CORT significantly (p &lt; 0.05) shortened buffy coat telomere length. UCP3 and COX6A1 were diversely and significantly expressed in the muscle, liver, and heart of the CORT-fed chicken. Significant expression of SAAL1 and CRP in the liver and hypothalamus of the CORT-fed chickens was observed at week 4 and 6. Therefore, telomere lengths, mitochondria, and acute phase protein genes could be used as novel biomarkers for GI tract pathologies and meat quality traits.<\/jats:p>","DOI":"10.3390\/ani11113276","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T10:23:17Z","timestamp":1637058197000},"page":"3276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Telomere Length, Apoptotic, and Inflammatory Genes: Novel Biomarkers of Gastrointestinal Tract Pathology and Meat Quality Traits in Chickens under Chronic Stress (Gallus gallus domesticus)"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-6161","authenticated-orcid":false,"given":"Kazeem Ajasa","family":"Badmus","sequence":"first","affiliation":[{"name":"Department of Animal Science, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"},{"name":"Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-7430","authenticated-orcid":false,"given":"Zulkifli","family":"Idrus","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"},{"name":"Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-2170","authenticated-orcid":false,"given":"Goh Yong","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"},{"name":"Department of Veterinary Pre-Clinical Science, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-8212","authenticated-orcid":false,"given":"Kamalludin","family":"Mamat-Hamidi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"},{"name":"Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, Seri Kembanga 43400, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.3382\/ps.0691348","article-title":"Energy metabolism of broiler breeder hens. Contribution of issues to total heat production in fed and fasted hens","volume":"69","author":"Spratt","year":"1990","journal-title":"Poult. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3382\/ps.2014-04099","article-title":"Acute phase proteins, interleukin 6, and heat shock protein 70 in broiler chickens administered with corticosterone","volume":"93","author":"Zulkifli","year":"2014","journal-title":"Poult. Sci."},{"key":"ref_3","unstructured":"Hayash, K., Kaneda, S., Otsuka, A., and Tomita, Y. (1992, January 19\u201324). Effects of ambient temperature and thyroxine on protein turnover and oxygen consumption in chicken skeletal muscle. Proceedings of the 19th World Poultry Congress, Amsterdam, The Netherlands."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3382\/ps.0590516","article-title":"Some effects of feeding corticosterone to chicken","volume":"59","author":"Gross","year":"1980","journal-title":"Poult. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.5713\/ajas.2008.80167","article-title":"Corticosterone administration alters small intestinal morphology and function of broiler chickens","volume":"21","author":"Hu","year":"2008","journal-title":"Asian-Austr. J. Anim. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.3382\/ps.0602232","article-title":"Some effects of feeding deoxycorticosterone to chickens","volume":"60","author":"Gross","year":"1981","journal-title":"Poult. Sci."},{"key":"ref_7","first-page":"83","article-title":"Effects of oral and parenteral corticosteroids on intestinal villous morphology and brush border enzymes in the rat","volume":"41","author":"Anama","year":"1979","journal-title":"Comp. Stud."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1203\/00006450-198402000-00006","article-title":"Intestinal development in the suckling rat. Effect of weaning, diet composition, and glucocorticoids on thymidine kinase activity and DNA synthesis","volume":"18","author":"Buts","year":"1984","journal-title":"Pediatr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cbpa.2006.12.034","article-title":"Altered development and protein metabolism in skeletal muscles of broiler chickens (Gallus gallus domesticus) by corticosterone","volume":"147","author":"Dong","year":"2007","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1016\/S0309-1740(98)90050-X","article-title":"Muscle fibre type and meat quality","volume":"48","author":"Klont","year":"1998","journal-title":"Meat Sci."},{"key":"ref_11","first-page":"10","article-title":"Effects of muscle fiber type on meat characteristics of chicken and duck breast muscle","volume":"54","author":"Kim","year":"2008","journal-title":"54th ICoMST"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI66370","article-title":"Telomeres and age-related disease: How telomere biology informs clinical paradigm","volume":"123","author":"Armanios","year":"2013","journal-title":"J. Clin. Invest."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj2080593","article-title":"Effect of corticosterone on myofibrillar protein turnover in diabetic rats as assessed by Ntau-methylhistidine excretion","volume":"205","author":"Tomas","year":"1982","journal-title":"Biochem. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tins.2004.07.005","article-title":"Free radicals and aging","volume":"27","author":"Barja","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fvets.2016.00071","article-title":"Editorial: Gut health: The new paradigm in food animal production","volume":"3","author":"Kogut","year":"2016","journal-title":"Front. Vet. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1586\/17474124.2013.848790","article-title":"Telomere and telomere dynamics: Relevance to cancer of the gastrointestinal tract","volume":"7","author":"Nivedita","year":"2013","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_18","first-page":"9","article-title":"Biomarkers of gastrointestinal functionality in animal nutrition and health","volume":"250","author":"Pietro","year":"2018","journal-title":"Anim. Feed Sci. Tech."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1101\/sqb.2000.65.253","article-title":"Molecular manifestations and molecular determinants of telomere capping","volume":"65","author":"Blackburn","year":"2000","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)80858-2","article-title":"Identification of human Rap1: Implications for telomere evolution","volume":"101","author":"Li","year":"2000","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wong, J.Y.Y., Vivo, I.D., Lin, X., Fang, S.C., and Christiani, D.C. (2014). The Relationship between Inflammatory Biomarkers and Telomere Length in an Occupational Prospective Cohort Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087348"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20133151","DOI":"10.1098\/rspb.2013.3151","article-title":"Stress exposure in early post-natal life reduces telomere length: An experimental demonstration in a long-lived seabird","volume":"281","author":"Herborn","year":"2014","journal-title":"Proc. R. Soc. B: Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/conphys\/cow073","article-title":"Corticosterone, Inflammation, Immune Status and Telomere Length in frigatebird nestlings facing a severe herpesvirus infection","volume":"5","author":"Sebastiano","year":"2017","journal-title":"Conserv. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, N.J., and Fenech, M. (2011). A quantitative PCR method for measuring absolute telomere length. BMC, 13.","DOI":"10.1186\/1480-9222-13-3"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3945\/ajcn.2008.26429","article-title":"Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"88","author":"Nettleton","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/gkn1027","article-title":"Telomere measurement by novel monochrome multiplex quantitative PCR method","volume":"37","author":"Cawthon","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1158\/1055-9965.EPI-08-0935","article-title":"Obesity and weight gain in adulthood and telomere length","volume":"18","author":"Kim","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2009.05.004","article-title":"Mitochondria and reactive oxygen species","volume":"47","author":"Kowaltowski","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"E512","DOI":"10.1152\/ajpendo.00446.2002","article-title":"Expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis","volume":"28","author":"Sun","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0092-8674(94)90203-8","article-title":"Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria","volume":"79","author":"Newmeyer","year":"1994","journal-title":"Cell"},{"key":"ref_32","first-page":"189197","article-title":"Human C-reactive protein: Expression, structure and function","volume":"38","author":"Volanikis","year":"2001","journal-title":"Mol. Immmunol."},{"key":"ref_33","first-page":"17","article-title":"Effect corticosterone Administration on Small Intestinal Weight and Expression of Small Intestinal Nutrient Transporter mRNA of Broiler Chickens *","volume":"23","author":"Hu","year":"2010","journal-title":"Asian-Austr. J. Anim. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for non-alcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0309-1740(98)00034-5","article-title":"Reference methods for the assessment of physical characteristics of meat","volume":"49","author":"Honikel","year":"1998","journal-title":"Meat Sci."},{"key":"ref_36","first-page":"23","article-title":"Carcass, meat and bone quality of broiler chickens fed with postbiotic and prebiotic combination","volume":"10","author":"Kareem","year":"2015","journal-title":"Int. J. Probiotics Prebiotics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2621.2004.tb17879.x","article-title":"Prediction of poultry meat tenderness using razor blade shear, allo Kramer shear and sarcomere length","volume":"69","author":"Cavitt","year":"2004","journal-title":"J. Food Sci."},{"key":"ref_38","unstructured":"Hunt, M.C. (1980, January 6\u20138). Meat color measurements. Proccedings of the Meat Conference, AMSA, Purdue University, Lafayette, Indiana. Available online: www.meatscience.org."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"Cawthon","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression using real-time quantitative PCR and the 2-\u0394\u0394CT","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_41","unstructured":"SAS (2002). Statistical Analysis System Multiple Incorporation. Users Guide Statistical Version, SAS Institute Inc."},{"key":"ref_42","unstructured":"Falconer, D.S. (1989). Introduction to Quantitative Genetics, Longman Scientific and Technical. [3rd ed.]."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Badmus, K.A., Idrus, Z., Goh, Y.M., Qurni, S.A., and Mamat-Hamidi, K. (2021). Telomere Length and Regulatory Genes as Novel Stress Biomarkers and their Diversities in Broiler Chickens (Gallus gallus domesticus) Subjected to Corticosterone Feeding. Animals, 11.","DOI":"10.3390\/ani11102759"},{"key":"ref_44","unstructured":"Kinney, J.M., and Tucker, H.N. (1992). Organ and Tissue Contribution to Metabolic Rate. Energy Metabolism. Tissue Determinants and Cellular Corollaries, Raven Press."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Fulkner, F., and Tanner, J.M. (1986). Body Composition and Energy Needs During Growth. Human Growth: A Comprehensive Treatise, Plenum Press.","DOI":"10.1007\/978-1-4613-2101-9"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.3382\/ps\/pev211","article-title":"Effect of dexamethasone in feed on intestinal permeability, differential white blood cell counts, and immune organs in broiler chicks","volume":"94","author":"Vicuna","year":"2015","journal-title":"Poult. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.23.011702.073036","article-title":"Trophic and cytoprotective nutrition for intestinaladaptation, mucosal repair, and barrier function","volume":"23","author":"Ziegler","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/00071669608417922","article-title":"Effects of fasting and refeeding on structures of the intestinal villus and epithelial cell in White Leghorn hens","volume":"37","author":"Yamauchi","year":"1996","journal-title":"Br. Poult. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1093\/jn\/130.9.2174","article-title":"Partialsequence and expression of the gene for and activity of the sodium glucose transporter in the small intestine of fed, starved and refed chickens","volume":"130","author":"Mabjeesh","year":"2000","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/jn\/134.11.2957","article-title":"Increased expression of specific intestinal amino acid and Peptide transporter mRNA in rats fed by TPN is reversed by GLP-2","volume":"134","author":"Howard","year":"2004","journal-title":"J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0300-9629(92)90641-3","article-title":"The effect of chronic exposure to elevated environmental temperature on intestinal morphology and nutrient absorption in the domestic fowl (Gallus domesticus)","volume":"101","author":"Mitchell","year":"1992","journal-title":"Comp. Biochem. Physiol."},{"key":"ref_52","first-page":"185","article-title":"Effect of garlic powder (Allium sativum) and black seed (Nigella sativa) on broiler growth performance and intestinal morphology","volume":"3","author":"Saeid","year":"2013","journal-title":"Iran. J. Appl. Anim. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/00071669987296","article-title":"Involvement of corticosterone in food intake, food passage time and in vivo uptake of nutrients in the chicken (Gallus domesticus)","volume":"40","author":"Nasir","year":"1999","journal-title":"Br. Poult. Sci."},{"key":"ref_54","unstructured":"Mathew, A., and Evan, B.J. (2013). Practice of Toxicologic Pathology. Hascheck and Rousseaux\u2019s Handbook of Toxicologic pathology, Elsevier. [3rd ed.]."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00000658-200109000-00008","article-title":"Telomerase activity in periampullary tumors correlates with aggressive malignancy","volume":"234","author":"Balcom","year":"2001","journal-title":"Ann. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-1110(96)90006-8","article-title":"The roles of telomeres and telomerase in cell life span","volume":"366","author":"Counter","year":"1996","journal-title":"Mutat. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.metabol.2015.11.008","article-title":"Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"65","author":"Thomas","year":"2016","journal-title":"Metabolism"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Donati, B., and Valenti, L. (2016). Telomeres, NAFLD and Chronic Liver Disease. Int. J. Mol. Sci., 3.","DOI":"10.3390\/ijms17030383"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1074\/jbc.M206818200","article-title":"Massive telomere loss is an early event of DNA damage-induced apoptosis","volume":"278","author":"Carracedo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/scientificamerican0296-92","article-title":"Telomeres, telomerase and cancer","volume":"274","author":"Greider","year":"1996","journal-title":"Sci. Am."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/35041694","article-title":"The age of cancer","volume":"408","author":"DePinho","year":"2000","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/(SICI)1097-0215(19970304)70:5<512::AID-IJC4>3.0.CO;2-0","article-title":"Smoking, alcohol use, dietary factors and risk of small intestinal adenocarcinoma","volume":"70","author":"Wu","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/carcin\/bgi063","article-title":"Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer","volume":"26","author":"Broberg","year":"2005","journal-title":"J. Carcinog."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.juro.2007.05.112","article-title":"Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer","volume":"178","author":"Shao","year":"2007","journal-title":"J. Urol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/j.1349-7006.2008.00831.x","article-title":"Telomere length and the risk of lung cancer","volume":"99","author":"Jang","year":"2008","journal-title":"Cancer Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1158\/1055-9965.EPI-07-0624","article-title":"Leukocyte telomere length predicts cancer risk in Barrett\u2019s esophagus","volume":"16","author":"Risques","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/0026-0495(81)90026-3","article-title":"Effect of corticosterone and its route of administration on muscle protein breakdown, measured in vivo by urinary excretion of N-methylhistidine in rats; Response to different levels of dietary protein and energy","volume":"30","author":"Santiago","year":"1981","journal-title":"Metabolism"},{"key":"ref_69","first-page":"873","article-title":"Poultry Meat Quality in Relation to Muscle Growth and Muscle Fiber Characteristics","volume":"37","author":"Ishamri","year":"2017","journal-title":"Korean J. Food Sci. An."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/ps\/76.11.1616","article-title":"The effect of seasonal heat stress on rigor development and the incidence of pale, exudative turkey meat","volume":"76","author":"McKee","year":"1997","journal-title":"Poult. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3382\/ps.2007-00007","article-title":"Corticosterone Alters Meat Quality by Changing Pre-and Postslaughter Muscle Metabolism","volume":"87","author":"Gao","year":"2008","journal-title":"Poult. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/14756366.2020.1733547","article-title":"In vivo antiaging effects of alkaline water supplementation","volume":"35","author":"Logozzi","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/00071669708417965","article-title":"Microstructure of white and dark turkey meat batters as affected by pH","volume":"38","author":"Barbut","year":"1997","journal-title":"Poult. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bbadis.2009.06.005","article-title":"Myoglobin causes oxidative stress, increase of.NO production and dysfunction of kidney\u2019s mitochondria","volume":"1792","author":"Plotnikov","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_75","unstructured":"Khadijah, N. (2014). Physiological Stress Responses and Meat Quality of Rabbits Subjected to Different Road Transportation and Slaughter Methods. [Ph.D. Thesis, University Putra]."},{"key":"ref_76","first-page":"2049","article-title":"Transport stress impact on postmortem metabolisms of turkey meat quality","volume":"37","author":"Boukhris","year":"2017","journal-title":"J. New Sci."},{"key":"ref_77","first-page":"331","article-title":"Genetic variability within and between breeds of poultry1technological meat quality","volume":"60","author":"Bihan","year":"2004","journal-title":"Poult. Sci. J."},{"key":"ref_78","first-page":"1695","article-title":"Chemical composition and physicochemical properties of meat from capons as affected by breed and age","volume":"8","author":"Diaz","year":"2010","journal-title":"Span. J. Agri. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/ps\/83.1.123","article-title":"Composition, Colour and Texture of Thai indigenous and broiler chicken muscles","volume":"83","author":"Wattanachaut","year":"2004","journal-title":"Poult. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1093\/nar\/gkw464","article-title":"Preferential extension of short telomeres induced by low extracellular pH","volume":"44","author":"Ge","year":"2016","journal-title":"Nucleic Acid Res."},{"key":"ref_81","first-page":"60","article-title":"Colonocyte telomere shortening is greater with dietary red meat than white meat and is attenuated by resistant starch","volume":"31","author":"Shusuke","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ijo.2012.170","article-title":"Myocardial substrate metabolism in obesity","volume":"37","author":"Rider","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/sj.bjc.6690617","article-title":"Acidic environment causes apoptosis by increasing caspase activity","volume":"80","author":"Park","year":"1999","journal-title":"Br. J. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.biocel.2005.05.013","article-title":"Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism","volume":"37","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/cvu214","article-title":"Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction","volume":"105","author":"Liu","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11897-008-0013-1","article-title":"Uncoupling Proteins in Heart Failure","volume":"5","author":"Laskowski","year":"2009","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng0397-269","article-title":"Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia","volume":"15","author":"Fleury","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2337\/diab.46.5.900","article-title":"Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis","volume":"46","author":"Gimeno","year":"1997","journal-title":"Diabetes"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0014-5793(99)01568-9","article-title":"Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells","volume":"462","author":"Hinz","year":"1999","journal-title":"FEBS Lett."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fnins.2014.00456","article-title":"Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress","volume":"8","author":"Spiers","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/S0140-6736(04)17402-3","article-title":"Uncoupling proteins in human heart","volume":"364","author":"Murray","year":"2004","journal-title":"Lancet"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gene.2016.02.044","article-title":"Serum amyloid A1: Structure, function and gene polymorphism","volume":"583","author":"Sun","year":"2016","journal-title":"Gene"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2174\/0929867323666160418114600","article-title":"Structure and Expression of Different Serum Amyloid A (SAA) Vari- ants and their Concentration-Dependent Functions During Host Insults","volume":"23","author":"Buck","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1385\/IR:30:3:261","article-title":"C-reactive protein: An activator of innate immunity and a modulator of adaptive immunity","volume":"30","author":"Mold","year":"2004","journal-title":"J. Immunol. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","author":"Thompson","year":"1999","journal-title":"Structure"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/11\/3276\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:30:58Z","timestamp":1760167858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/11\/11\/3276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":98,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ani11113276"],"URL":"https:\/\/doi.org\/10.3390\/ani11113276","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]}}}