{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:55:30Z","timestamp":1788418530140,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In this study, we have investigated the impact of vitamin C on the production of pro-inflammatory cytokines (interleukin 1 \u03b2 (IL-1 \u03b2), interleukin 6 (IL-6), interleukin 12p40 (IL-12p40), interferon gamma (IFN\u03b3), and tumor necrosis factor alpha (TNF-\u03b1)) in lambs naturally infected by pneumonic pasteurellosis. Of 37 lambs, 18 lambs were identified to have pneumonic pasteurellosis and randomly allocated into two equal groups. Single subcutaneous dose of tulathromycine alone (2.5 mg kg\u22121) or tulathromycine combined with vitamin C (3 gm kg\u22121) were administrated to the diseased lambs. The serum levels of IL-1\u03b2, IL-6, IFN-\u03b3, and TNF-\u03b1 were returned to the normal levels in pneumonic lambs treated with the combination therapy. The obtained results indicate the selective influences of vitamin C on pro-inflammatory cytokines production in sera of lambs with pneumonic pasteurellosis and highlights the value of vitamin C as a potential anti-inflammatory drug and ideal immunomodulatory agent.<\/jats:p>","DOI":"10.3390\/ani11123374","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:19:16Z","timestamp":1638137956000},"page":"3374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immunomodulatory Effect of Vitamin C on Proinflammatory Cytokines Production in Ossimi Lambs (Ovis aries) with Pneumonic Pasteurellosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-6172","authenticated-orcid":false,"given":"Mohamed Abdo","family":"Rizk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-5731","authenticated-orcid":false,"given":"Shimaa Abd El-Salam","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma H.","family":"Marghani","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam Elshahat","family":"Gadalla","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-8256","authenticated-orcid":false,"given":"Mohamed Z.","family":"Sayed-Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"},{"name":"Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jizan 82722, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11259-008-9178-z","article-title":"Immunohistochemical detection of Mannheimia (Pasteurella) haemolytica antigens in goats with natural pneumonia","volume":"33","author":"Yener","year":"2009","journal-title":"Vet. 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