{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:01:02Z","timestamp":1768006862663,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study investigated the effects of Goji berry (Lycium barbarum) dietary supplementation during pregnancy on insulin sensitivity of rabbit does and their offspring. Starting from two months before the artificial insemination, 75 New Zealand White does were fed only commercial standard diet (C) or supplemented with 1% (G1) and 3% (G3) of Goji berries. Their offspring received a standard diet but kept the nomenclature of the mother\u2019s group. Fasting and intravenous glucose tolerance test-derived indices were estimated at 21 days of pregnancy on rabbit does and at 90 days of age on the offspring. No difference was found in the fasting indices, while the diet modulated the response to glucose load of rabbit does. In particular, G3 group had the lowest glucose concentrations 5 min after the bolus administration (p &lt; 0.05) and, as a result, differed in the parameters calculated during the elimination phase such as the elimination rate constant (Kel), the half-life of the exogenous glucose load (t1\/2), and apparent volume of distribution (Vd; for all, p &lt; 0.05). The high dose of Goji supplementation could thus enhance the first-phase glucose-induced insulin secretion. Findings on the offspring were inconsistent and therefore a long-term effect of Goji supplementation during pregnancy could not be demonstrated. Further study on the effect of Goji on the secretory pathway of insulin could clarify its hypoglycaemic action, while different protocols are needed to investigate its potential effects on foetal programming.<\/jats:p>","DOI":"10.3390\/ani12010039","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:00:54Z","timestamp":1640566854000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Goji Berry (Lycium barbarum) Supplementation during Pregnancy Influences Insulin Sensitivity in Rabbit Does but Not in Their Offspring"],"prefix":"10.3390","volume":"12","author":[{"given":"Gabriele","family":"Brecchia","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majlind","family":"Sulce","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Albania, Rr Paisi Vodica, Koder, 1029 Kamez, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-0036","authenticated-orcid":false,"given":"Giulio","family":"Curone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-4610","authenticated-orcid":false,"given":"Olimpia","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Canali","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-6115","authenticated-orcid":false,"given":"Alessandro","family":"Troisi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Camerino Via Circonvallazione 93\/95, 62024 Matelica, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albana","family":"Munga","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Albania, Rr Paisi Vodica, Koder, 1029 Kamez, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Polisca","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Agradi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-4890","authenticated-orcid":false,"given":"Maria Rachele","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti, 48, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-4992","authenticated-orcid":false,"given":"Daniele","family":"Vigo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alda","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06121 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Draghi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7970","authenticated-orcid":false,"given":"Laura","family":"Menchetti","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, University of Bologna, Viale G. 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