{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:48:41Z","timestamp":1788558521146,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In humans, mirtazapine can prevent chemotherapy-induced nausea and vomiting (CINV) and improve cancer patients\u2019 quality of life (QoL). This drug is being increasingly used as an appetite stimulant in cats. The hypothesis of this retrospective study was that mirtazapine could reduce the incidence of CINV and weight loss in feline patients affected by lymphoma. The objectives were to report the use of mirtazapine transdermal ointment and assess the incidence of gastrointestinal (GI) toxicity and weight loss in cats diagnosed with lymphoma and receiving chemotherapy. Transdermal mirtazapine was topically administered to the inner surface of the pinna (2 mg\/cat\/daily) for 14 days following chemotherapy administration. Data recorded from 20 patients were collected. Different grades of GI toxicity were shown in 8\/20 (40%) patients. Body weight (BW), body condition score (BCS), and muscle condition score (MCS) improved in 12\/20 (60%), 6\/20 (30%), and 2\/20 (10%) cats, respectively. Mirtazapine-induced adverse events (AEs) occurred in 4\/20 (20%) cats and did not require mirtazapine discontinuation. Substantial weight loss was not encountered, suggesting that patients had an adequate food intake after chemotherapy administration. Transdermal mirtazapine ointment was considered safe and well tolerated.<\/jats:p>","DOI":"10.3390\/ani12020155","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:29:26Z","timestamp":1641760166000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Appetite Stimulant and Anti-Emetic Effect of Mirtazapine Transdermal Ointment in Cats Affected by Lymphoma Following Chemotherapy Administration: A Multi-Centre Retrospective Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-7132","authenticated-orcid":false,"given":"Livia","family":"Ferro","sequence":"first","affiliation":[{"name":"Anicura Istituto Veterinario Novara, 28060 Granozzo con Monticello, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-5784","authenticated-orcid":false,"given":"Stefano","family":"Ciccarelli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Bari \u201cAldo Moro\u201d, 370100 Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Stanzani","sequence":"additional","affiliation":[{"name":"Dick White Referrals, Cambridgeshire CB8 0UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nappi","sequence":"additional","affiliation":[{"name":"Anicura Centro Oncologico Veterinario, 40037 Sasso Marconi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Angelini","sequence":"additional","affiliation":[{"name":"Anicura Clinica Veterinaria CMV, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8700-2230","authenticated-orcid":false,"given":"Chiara","family":"Leo","sequence":"additional","affiliation":[{"name":"Anicura Istituto Veterinario Novara, 28060 Granozzo con Monticello, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Williams, J., Phillips, C., and Byrd, H.M. 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