{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:57:42Z","timestamp":1780977462342,"version":"3.54.1"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study was conducted to evaluate the productive performance, intestinal health, and description of the cecum microbiota in broilers supplemented with \u03b2-mannanases (MNs) and bacteriophages (BPs). Six hundred one-day-old broilers were divided into four groups and fed one of the following diets: CON\u2014corn\u2013soybean meal + 10 ppm enramycin (ENR); MN: CON + 500 ppm MN; BP: CON + 500 ppm BP; MN + BP: BP + 500 ppm MN. The BP and MN factors showed similar performances to ENR. MN improved the concentration of IgA in the jejunum at 35 days of age. The morphometric index (IM) of the thymus increased by adding MN, while BP increased the liver and thymus IM. The histological analysis showed that BP and MN improved the intestinal morphology. MN + BP showed a tendency to decrease the abundance of Proteobacteria and increase the abundance of Bacteroidetes, indicating better microbiota function. In conclusion, our results demonstrate that the combination of MN + BP has potential in poultry nutrition; however, we highly recommend further experiments to confirm this hypothesis.<\/jats:p>","DOI":"10.3390\/ani12020169","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T14:05:07Z","timestamp":1641909907000},"page":"169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Productive Performance and Cecum Microbiota Analysis of Broiler Chickens Supplemented with \u03b2-Mannanases and Bacteriophages\u2014A Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-2179","authenticated-orcid":false,"given":"Carlos A.","family":"Pantoja-Don Juan","sequence":"first","affiliation":[{"name":"Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad 3000, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"G\u00f3mez-Verduzco","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Zootecnia de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad 3000, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-381X","authenticated-orcid":false,"given":"Claudia C.","family":"M\u00e1rquez-Mota","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n Animal y Bioqu\u00edmica, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad 3000, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-2747","authenticated-orcid":false,"given":"Guillermo","family":"T\u00e9llez-Isa\u00edas","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young M.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Cort\u00e9s-Cuevas","sequence":"additional","affiliation":[{"name":"Centro de Ense\u00f1anza, Investigaci\u00f3n y Extensi\u00f3n en Producci\u00f3n Av\u00edcola CEIEPAv, Tl\u00e1huac 13300, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Arce-Menocal","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Av\u00edcola, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Santiago Tapia 403, Centro, Morelia 58000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mart\u00ednez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Agr\u00edcola y Animal, Universidad Aut\u00f3noma Metropolitana, Calz. del Hueso 1100, Coapa, Villa Quietud, Coyoac\u00e1n, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"\u00c1vila-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Ense\u00f1anza, Investigaci\u00f3n y Extensi\u00f3n en Producci\u00f3n Av\u00edcola CEIEPAv, Tl\u00e1huac 13300, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3389\/fmicb.2015.01336","article-title":"Alternatives to antibiotics to prevent necrotic enteritis in broiler chickens: A microbiologist\u2019s perspective","volume":"6","author":"Caly","year":"2015","journal-title":"Front. 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