{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:54:44Z","timestamp":1792788884490,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Modern Argo-Industry Technology Research System of China","award":["CARS-40-K10"],"award-info":[{"award-number":["CARS-40-K10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study was designed to evaluate the effects of dietary coated sodium butyrate (CSB) on the intestinal antioxidant, immune function, and cecal microbiota of laying hens. A total of 720 52-week-old Huafeng laying hens were randomly allocated into five groups and fed a basal diet supplemented with CSB at levels of 0 (control), 250 (S250), 500 (S500), 750 (S750), and 1000 (S1000) mg\/kg for eight weeks. The results revealed that CSB supplementation quadratically decreased the malondialdehyde content and increased the superoxide dismutase activity of the jejunum as well as the total antioxidative capacity activity of the ileum (p &lt; 0.05). Dietary CSB supplementation linearly decreased the diamine oxidase and D-lactic acid content of the serum (p &lt; 0.05). Compared with the control group, the addition of CSB resulted in linear and\/or quadratic effects on the mRNA expression of inflammatory cytokines TNF-\u03b1, IL-6, and IL-10 in the jejunum and ileum (p &lt; 0.05). The short-chain fatty acid concentrations increased quadratically as supplemental CSB improved (p &lt; 0.05). Additionally, dietary CSB levels had no effect on microbial richness estimators, but ameliorated cecal microbiota by raising the abundance of probiotics and lowering pathogenic bacteria enrichment. In conclusion, our results suggest that dietary supplementation with CSB could improve the intestinal health of laying hens via positively influencing the antioxidant capacity, inflammatory cytokines, short-chain fatty acids, and gut microbiota. In this study, 500\u2009mg\/kg CSB is the optimal supplement concentration in the hens\u2019 diet.<\/jats:p>","DOI":"10.3390\/ani12050545","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:35:09Z","timestamp":1645569309000},"page":"545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Alterations in Intestinal Antioxidant and Immune Function and Cecal Microbiota of Laying Hens Fed on Coated Sodium Butyrate Supplemented Diets"],"prefix":"10.3390","volume":"12","author":[{"given":"Sasa","family":"Miao","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuopeng","family":"Hong","sequence":"additional","affiliation":[{"name":"Jiande Weifeng Feed Co. Ltd., Jiande 311600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Jian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-2518","authenticated-orcid":false,"given":"Qianqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fsi.2019.02.064","article-title":"Sodium butyrate supplementation in high-soybean meal diets for turbot (Scophthalmus maximus L.): Effects on inflammatory status, mucosal barriers and microbiota in the intestine","volume":"88","author":"Liu","year":"2019","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_2","first-page":"789814","article-title":"Therapeutic potential of tolerogenic dendritic cells in IBD: From animal models to clinical application","volume":"2013","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.fsi.2017.12.009","article-title":"Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella)","volume":"73","author":"Wu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2527\/jas.2013-7087","article-title":"Triennial Growth Symposium--A role for vitamin D in skeletal muscle development and growth","volume":"92","author":"Starkey","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.vetpar.2015.06.026","article-title":"Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock","volume":"212","author":"Hoste","year":"2015","journal-title":"Vet. Parasitol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2478\/aoas-2019-0077","article-title":"Effect of sodium butyrate on intestinal health of poultry-a review","volume":"20","author":"Elnesr","year":"2020","journal-title":"Ann. Anim. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1111\/bph.13058","article-title":"Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning","volume":"172","author":"Henagan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jnutbio.2006.12.012","article-title":"Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells","volume":"18","author":"Sauer","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wang, C.C., Shen, Z.J., Cao, S.T., Zhang, Q.H., Peng, Y., Hong, Q.H., Feng, J., and Hu, C.H. (2019). Effects of tributyrin on growth performance, intestinal microflora and barrier function of weaned pigs. Anim. Feed Sci. Technol., 258.","DOI":"10.1016\/j.anifeedsci.2019.114311"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1038\/s41598-018-22565-6","article-title":"Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.micpath.2016.11.002","article-title":"Weight gain by gut microbiota manipulation in productive animals","volume":"106","author":"Angelakis","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.rvsc.2020.01.020","article-title":"Characteristics of the fecal microbiota of high- and low-yield hens and effects of fecal microbiota transplantation on egg production performance","volume":"129","author":"Wang","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"577236","DOI":"10.3389\/fcimb.2021.577236","article-title":"Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury","volume":"11","author":"Li","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2527\/jas.53959","article-title":"Evaluation of different protections of butyric acid aiming for release in the last part of the gastrointestinal tract of piglets","volume":"90","author":"Mallo","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1080\/1828051X.2021.1960209","article-title":"Effects of coated sodium butyrate on production performance, egg quality, serum biochemistry, digestive enzyme activity, and intestinal health of laying hens","volume":"20","author":"Miao","year":"2021","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110372","DOI":"10.1016\/j.ecoenv.2020.110372","article-title":"Alterations in cecal microbiota and intestinal barrier function of laying hens fed on fluoride supplemented diets","volume":"193","author":"Miao","year":"2020","journal-title":"Ecotox. Environ. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1038\/s41598-017-06677-z","article-title":"Effect of probiotics on the meat flavour and gut microbiota of chicken","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4704771","DOI":"10.1155\/2021\/4704771","article-title":"Dietary valine ameliorated gut health and accelerated the development of nonalcoholic fatty liver disease of laying hens","volume":"23","author":"Jian","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2527\/jas.50965","article-title":"Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions","volume":"4","author":"Ma","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Russo, I., Luciani, A., De Cicco, P., Troncone, E., and Ciacci, C. (2012). Butyrate attenuates lipopolysaccharide-induced inflammation in intestinal cells and Crohn\u2019s mucosa through modulation of antioxidant defense machinery. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032841"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lin, Y., Fang, Z.F., Che, L.Q., Xu, S.Y., Wu, D., Wu, C.M., and Wu, X.Q. (2014). Use of sodium butyrate as an alternative to dietary fiber: Effects on the embryonic development and anti-oxidative capacity of rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097838"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1071\/AN13348","article-title":"Micro-encapsulated sodium butyrate attenuates oxidative stress induced by corticosterone exposure and modulates apoptosis in intestinal mucosa of broiler chickens","volume":"55","author":"Jiang","year":"2015","journal-title":"Anim. Prod. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.3892\/mmr.2014.2544","article-title":"Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model","volume":"10","author":"Zhang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1039\/C5FO01194A","article-title":"Dietary arginine and N-carbamylglutamate supplementation enhances the antioxidant statuses of the liver and plasma against oxidative stress in rats","volume":"7","author":"Cao","year":"2016","journal-title":"Food Funct."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/gut.2005.085373","article-title":"Alterations in intestinal permeability","volume":"55","author":"Arrieta","year":"2006","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3389\/fimmu.2018.01270","article-title":"Cytokine tuning of intestinal epithelial function","volume":"9","author":"Andrews","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.immuni.2015.09.003","article-title":"Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jnutbio.2015.09.020","article-title":"Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase","volume":"27","author":"Zhang","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lor\u00e9n, V., Cabr\u00e9, E., Ojanguren, I., Dom\u00e8nech, E., Pedrosa, E., Garc\u00eda-Jaraquemada, A., Ma\u00f1osa, M., and Many\u00e9, J. (2015). Interleukin-10 enhances the intestinal epithelial barrier in the presence of Corticosteroids through p38 MAPK activity in Caco-2 monolayers: A possible mechanism for steroid responsiveness in ulcerative colitis. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0130921"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.4049\/jimmunol.1301757","article-title":"IFN-\u03b3-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia","volume":"192","author":"Kominsky","year":"2014","journal-title":"J. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1172\/JCI90229","article-title":"Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling","volume":"127","author":"Quiros","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12263-011-0229-7","article-title":"Intestinal microbiota in human health and disease: The impact of probiotics","volume":"6","author":"Gerritsen","year":"2011","journal-title":"Genes Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","article-title":"Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides","volume":"81","author":"Topping","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.carbpol.2017.12.048","article-title":"Structural characterization and in vitro fermentation of a novel polysaccharide from Sargassum thunbergii and its impact on gut microbiota","volume":"183","author":"Fu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09646","article-title":"Bifidobacteria can protect from enteropathogenic infection through production of acetate","volume":"469","author":"Fukuda","year":"2011","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.redox.2021.102165","article-title":"Short-chain fatty acids as modulators of redox signaling in health and disease","volume":"47","author":"Boorman","year":"2021","journal-title":"Redox Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1080\/10408398.2018.1542587","article-title":"Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria","volume":"59","author":"Fu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Salvi, P.S., and Cowles, R.A. (2021). Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease. Cells, 10.","DOI":"10.3390\/cells10071775"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40168-018-0439-y","article-title":"Microbiome-host systems interactions: Protective effects of propionate upon the blood-brain barrier","volume":"6","author":"Hoyles","year":"2018","journal-title":"Microbiome"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.2478\/aoas-2020-0050","article-title":"Effect of dietary sodium acetate on skin mucus immune parameters and expression of gene related to growth, immunity and antioxidant system in common carp (Cyprinus carpio) intestine","volume":"20","author":"Safari","year":"2020","journal-title":"Ann. Anim. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.3382\/ps\/pez279","article-title":"Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers","volume":"98","author":"Zou","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.fsi.2019.04.025","article-title":"Effects of prebiotic mixtures on growth performance, intestinal microbiota and immune response in juvenile chu\u2019s croaker, Nibea coibor","volume":"89","author":"Li","year":"2019","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Videnska, P., Sedlar, K., Lukac, M., Faldynova, M., Gerzova, L., Cejkova, D., Sisak, F., and Rychlik, I. (2014). Succession and replacement of bacterial populations in the caecum of egg laying hens over their whole life. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115142"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1757-4749-5-23","article-title":"Commensal Clostridia: Leading players in the maintenance of gut homeostasis","volume":"5","author":"Lopetuso","year":"2013","journal-title":"Gut Pathog."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/1751-7915.13566","article-title":"Resveratrol affectsin vitro rumen fermentation, methane production and prokaryotic community composition in a time- and diet-specific manner","volume":"13","author":"Ma","year":"2020","journal-title":"Microb. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Vacca, M., Celano, G., Calabrese, F.M., Portincasa, P., Gobbetti, M., and De Angelis, M. (2020). The controversial role of human gut Lachnospiraceae. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040573"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"153268","DOI":"10.1016\/j.phymed.2020.153268","article-title":"Cyclocarya paliurus polysaccharides alleviate type 2 diabetic symptoms by modulating gut microbiota and short-chain fatty acids","volume":"77","author":"Yao","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/003655202320378220","article-title":"Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls","volume":"37","author":"Kleessen","year":"2002","journal-title":"Scand J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1099\/jmm.0.46198-0","article-title":"Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis","volume":"55","author":"Lucke","year":"2006","journal-title":"J. Med. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"585197","DOI":"10.3389\/fmicb.2020.585197","article-title":"The combination of lead and bacillus coagulans R11 increased the concentration of alpha-Solanine in the cecum of laying hens and the pathogens abundance decreased","volume":"11","author":"Xing","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1574-6968.2000.tb09265.x","article-title":"Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin","volume":"190","author":"Wright","year":"2000","journal-title":"FEMS Microbiol. Lett."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/5\/545\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:25:13Z","timestamp":1760135113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/5\/545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ani12050545"],"URL":"https:\/\/doi.org\/10.3390\/ani12050545","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]}}}