{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:51:55Z","timestamp":1777909915837,"version":"3.51.4"},"reference-count":77,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003046","name":"Brazilian Agricultural Research Corporation","doi-asserted-by":"publisher","award":["01.11.07.002.04.03"],"award-info":[{"award-number":["01.11.07.002.04.03"]}],"id":[{"id":"10.13039\/501100003046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS\/FHN in chickens and humans.<\/jats:p>","DOI":"10.3390\/ani12060788","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:25:00Z","timestamp":1647811500000},"page":"788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive Analyses of Bone and Cartilage Transcriptomes Evince Ion Transport, Inflammation and Cartilage Development-Related Genes Involved in Chickens\u2019 Femoral Head Separation"],"prefix":"10.3390","volume":"12","author":[{"given":"Iara","family":"Goldoni","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, R. Salvatore Renna, 875, Guarapuava 85015-430, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-8879","authenticated-orcid":false,"given":"Adriana M\u00e9rcia Guaratini","family":"Ibelli","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, R. Salvatore Renna, 875, Guarapuava 85015-430, PR, Brazil"},{"name":"Embrapa Su\u00ednos e Aves, Rodovia BR 153, km 110, Conc\u00f3rdia 89715-899, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana Teixeira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Rodovia BR 153, km 110, Conc\u00f3rdia 89715-899, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane de Oliveira","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, R. Salvatore Renna, 875, Guarapuava 85015-430, PR, Brazil"},{"name":"Embrapa Su\u00ednos e Aves, Rodovia BR 153, km 110, Conc\u00f3rdia 89715-899, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila Mudri","family":"Hul","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, R. Salvatore Renna, 875, Guarapuava 85015-430, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Eg\u00eddio","family":"Cant\u00e3o","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Rodovia BR 153, km 110, Conc\u00f3rdia 89715-899, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-094X","authenticated-orcid":false,"given":"Jo\u00e3o Jos\u00e9 de Simoni","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias no Semi\u00e1rido, Universidade Federal do Vale do S\u00e3o Francisco, UNIVASF, Rodovia BR 407, 12 Lote 543, Petrolina 56300-000, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-4735","authenticated-orcid":false,"given":"M\u00f4nica Corr\u00eaa","family":"Ledur","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Rodovia BR 153, km 110, Conc\u00f3rdia 89715-899, SC, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, UDESC-Oeste, Rua Beloni Trombeta Zanin, 680E, Chapec\u00f3 89815-630, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"ref_1","first-page":"126","article-title":"A cadeia de carne de frango: Uma an\u00e1lise dos mercados brasileiro e mundial de 2002 a 2012","volume":"21","author":"Voila","year":"2015","journal-title":"Rev. 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