{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:09:06Z","timestamp":1790820546902,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Feline leukemia virus (FeLV) infection is considered a poor prognostic factor for feline lymphoma. This study investigated the prevalence of cats suffering from feline lymphoma with natural infection of the feline leukemia virus, as well as clinical signs, adverse events, and survival time after cyclophosphamide, vincristine and prednisolone (COP) chemotherapy. This retrospective study involved 92 cats diagnosed with mediastinal or mediastinal plus other anatomical sites of lymphoma and treated with COP chemotherapy. FeLV-antigen-positive was observed in all cats. Clinical signs and adverse events were observed after the 1st, 2nd, and 3rd inductions. Clinical signs improved after the 3rd induction of COP chemotherapy. The response rate was 96.74% (81.52% complete response, 15.22% partial response, and 3.26% no response). The overall median survival time was 338 days (range 62\u20131057 days). The overall response rate and median survival time of cats with feline lymphoma that were FeLV-antigen-positive and treated with COP chemotherapy were higher than from other studies. This study found that cats aged &lt;4 years survived longer than those aged at least 4 years. Anemia (before COP), azotemia (after 2nd induction), and elevated alanine aminotransferase (after 1st induction) were associated with an increased chance of mortality.<\/jats:p>","DOI":"10.3390\/ani12070900","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:33:03Z","timestamp":1648762383000},"page":"900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effectiveness and Adverse Events of Cyclophosphamide, Vincristine, and Prednisolone Chemotherapy in Feline Mediastinal Lymphoma Naturally Infected with Feline Leukemia Virus"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-9556","authenticated-orcid":false,"given":"Supita","family":"Sunpongsri","sequence":"first","affiliation":[{"name":"Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"},{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-5234","authenticated-orcid":false,"given":"Attawit","family":"Kovitvadhi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-0961","authenticated-orcid":false,"given":"Jatuporn","family":"Rattanasrisomporn","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viphavee","family":"Trisaksri","sequence":"additional","affiliation":[{"name":"Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichakorn","family":"Jensirisak","sequence":"additional","affiliation":[{"name":"Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-8297","authenticated-orcid":false,"given":"Tassanee","family":"Jaroensong","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Chatuchak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3322\/caac.21349","article-title":"Cancer treatment and survivorship statistics, 2016","volume":"66","author":"Miller","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Thandra, K.C., Barsouk, A., Saginala, K., Padala, S.A., Barsouk, A., and Rawla, P. (2021). Epidemiology of Non-Hodgkin\u2019s Lymphoma. Med. Sci., 9.","DOI":"10.3390\/medsci9010005"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tvjl.2019.01.003","article-title":"Incidence, characteristics and geographical distributions of canine and human non-Hodgkin\u2019s lymphoma in the Porto region (North West Portugal)","volume":"245","author":"Pinello","year":"2019","journal-title":"Vet. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/vco.12158","article-title":"Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004\u20132012)","volume":"14","author":"Collette","year":"2016","journal-title":"Vet. Comp. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/jsap.13266","article-title":"Incidence and risk factors for feline lymphoma in UK primary-care practice","volume":"62","author":"Economu","year":"2021","journal-title":"J. Small Anim. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1292\/jvms.13-0260","article-title":"Prognostic analyses on anatomical and morphological classification of feline lymphoma","volume":"76","author":"Sato","year":"2014","journal-title":"J. Vet. Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/1098612X13516621","article-title":"Feline mediastinal lymphoma: A retrospective study of signalment, retroviral status, response to chemotherapy and prognostic indicators","volume":"16","author":"Fabrizio","year":"2014","journal-title":"J. Feline Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1939-1676.2002.tb02352.x","article-title":"Chemotherapy with cyclophosphamide, vincristine, and prednisolone (COP) in cats with malignant lymphoma: New results with an old protocol","volume":"16","author":"Teske","year":"2002","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1751-0813.1998.tb12300.x","article-title":"Clinical and anatomical features of lymphosarcomain 118 cats","volume":"76","author":"Gabor","year":"1998","journal-title":"Aust. Vet. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1939-1676.1998.tb02134.x","article-title":"Feline Lymphoma (145 Cases) Proliferation Indices Cluster of Differentiation 3 Immunoreactivity and Their Association with Prognosis in 90 Cats","volume":"12","author":"Vail","year":"1998","journal-title":"J. Vet. Intern. Med."},{"key":"ref_11","first-page":"329","article-title":"Feline Lymphoma in the Post Feline Leukemia Virus Era","volume":"19","author":"Louwerens","year":"2005","journal-title":"J. Vet. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/104063870001200401","article-title":"The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation","volume":"12","author":"Valli","year":"2000","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/jfms.2000.0079","article-title":"Advances in the treatment of the cat with lymphoma in practice","volume":"2","author":"Couto","year":"2000","journal-title":"J. Feline Med. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cvsm.2020.05.006","article-title":"What\u2019s New in Feline Leukemia Virus Infection","volume":"50","author":"Hartmann","year":"2020","journal-title":"Vet. Clin. Small Anim. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jcpa.2018.10.171","article-title":"Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil","volume":"166","author":"Cristo","year":"2019","journal-title":"J. Comp. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4236\/ojvm.2012.21003","article-title":"Epidemiological Aspects and Clinicopathological Findings in Cats Naturally Infected with Feline Leukemia Virus (FeLV) and\/or Feline Immunodeficiency Virus (FIV)","volume":"2","author":"Collado","year":"2012","journal-title":"Open J. Vet. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1177\/1098612X18816489","article-title":"Retrospective analysis of pleural effusion in cats","volume":"21","author":"Konig","year":"2019","journal-title":"J. Feline Med. Surg."},{"key":"ref_18","first-page":"696","article-title":"Treatment and prognostic factors in lymphoma in cats: 103 cases (1977\u20131981)","volume":"194","author":"Mooney","year":"1989","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/1098612X20926893","article-title":"LOPH: A novel chemotherapeutic protocol for feline high-grade multicentric or mediastinal lymphoma, developed in an area endemic for feline leukemia virus","volume":"23","author":"Horta","year":"2021","journal-title":"J. Feline Med. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/1098612X17735989","article-title":"Mechlorethamine, vincristine, melphalan and prednisolone rescue chemotherapy protocol for resistant feline lymphoma","volume":"20","author":"Martin","year":"2018","journal-title":"J. Feline Med. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1939-1676.2008.0057.x","article-title":"Combination Chemotherapy in Feline Lymphoma Treatment Outcome Tolerability and Duration in 23 Cats","volume":"22","author":"Simon","year":"2008","journal-title":"J. Vet. Intern. Med."},{"key":"ref_22","first-page":"12","article-title":"Retrospective Study of Adverse Events of Chemotherapy in Cats","volume":"46","author":"Cunha","year":"2018","journal-title":"Acta Sci. Vet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/vco.12677","article-title":"Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) following investigational therapy in dogs and cats","volume":"19","author":"LeBlanc","year":"2021","journal-title":"Vet. Comp. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s007050050079","article-title":"Feline leukaemia virus proviral DNA detected by polymerase chain reaction in antigenaemic but non-viraemic (\u2018discordant\u2019) cats","volume":"142","author":"Miyazawa","year":"1997","journal-title":"Arch. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1751-0813.1997.tb14347.x","article-title":"Retrospective study of 60 cases of feline lymphosarcoma","volume":"75","author":"Court","year":"1997","journal-title":"Aust. Vet. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1939-1676.1994.tb03205.x","article-title":"Feline Spinal Lymphosarcoma A Retrospective Evaluation of 23 Cats","volume":"8","author":"Lane","year":"1994","journal-title":"J. Vet. Intern. Med."},{"key":"ref_27","first-page":"971","article-title":"Comparison of age-and sex-specific incidence rate patterns of the leukemia complex in the cat and the dog","volume":"70","author":"Schneider","year":"1983","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Jaroensong, T., Piamwaree, J., and Sattasathuchana, P. (2022). Effects of Chemotherapy on Hematological Parameters and CD4+\/CD8+ Ratio in Cats with Mediastinal Lymphoma and Seropositive to Feline Leukemia Virus. Animals, 12.","DOI":"10.3390\/ani12030223"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.1128\/jvi.68.12.8296-8303.1994","article-title":"Genetic determinants of feline leukemia virus-induced lymphoid tumors: Patterns of proviral insertion and gene rearrangement","volume":"68","author":"Tsatsanis","year":"1994","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.vetimm.2008.01.019","article-title":"Molecular pathogenesis of feline leukemia virus-induced malignancies: Insertional mutagenesis","volume":"123","author":"Fujino","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00705-018-3721-1","article-title":"Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats","volume":"163","author":"Sumi","year":"2018","journal-title":"Arch. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1098612X19895940","article-title":"2020 AAFP feline retrovirus testing and management guidelines","volume":"22","author":"Little","year":"2020","journal-title":"J. Feline Med. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/vco.12325","article-title":"Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study","volume":"16","author":"Finotello","year":"2018","journal-title":"Vet. Comp. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/vms3.9","article-title":"Outcome and toxicity assessment of feline small cell lymphoma: 56 cases (2000\u20132010)","volume":"1","author":"Pope","year":"2015","journal-title":"Vet. Med. Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/7\/900\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:47:59Z","timestamp":1760136479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/7\/900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["ani12070900"],"URL":"https:\/\/doi.org\/10.3390\/ani12070900","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]}}}