{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:41Z","timestamp":1787027561962,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The John and Mary Kibble Trust Fund","award":["2017002696"],"award-info":[{"award-number":["2017002696"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Canine splenic fibrohistiocytic nodules traditionally encompassed benign lymphoid hyperplasia, complex hyperplasia, and malignant fibrous histiocytoma. The latter has been recently re-classified into histiocytic sarcoma and stromal sarcoma. Reliable indicators of post-splenectomy survival and demographic factors predisposing to the four types of nodules are not completely understood. This study aims to estimate frequency, survival times, and identify risk factors of splenectomized dogs diagnosed with lymphoid hyperplasia, complex hyperplasia, histiocytic sarcoma, and stromal sarcoma using medical records containing histopathological diagnosis from the VetCompass Australia database (1989\u20132018), which collects demographic, and clinical information from veterinary clinics. Out of 693 dogs, 315 were diagnosed with fibrohistiocytic nodules, mostly lymphoid hyperplasia (169\/693, 24.4%), followed by stromal sarcoma (59\/693, 8.5%), complex hyperplasia (55\/693, 7.9%), and histiocytic sarcoma (32\/693, 4.6%). Dogs aged 8\u201310 years were more likely to be diagnosed with histiocytic or stromal sarcoma than lymphoid hyperplasia. Dogs diagnosed with lymphoid hyperplasia had a longer survival time than those with other diagnoses (median &gt; 2 years). Dogs diagnosed with histiocytic sarcoma had longer survival times (median 349 days) than stromal sarcoma (median 166 days). Results suggest that knowledge of the type of splenic fibrohistiocytic nodule, patients\u2019 age, and sex can be used to increase prognostic accuracy.<\/jats:p>","DOI":"10.3390\/ani12080960","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:11:14Z","timestamp":1649419874000},"page":"960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiology and Survival of Dogs Diagnosed with Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Stromal Sarcoma and Histiocytic Sarcoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-0470","authenticated-orcid":false,"given":"Cleide H.","family":"Spr\u00f6hnle-Barrera","sequence":"first","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"McGhie","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-7125","authenticated-orcid":false,"given":"Rachel E.","family":"Allavena","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.","family":"Owen","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-6066","authenticated-orcid":false,"given":"Chiara","family":"Palmieri","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-2147","authenticated-orcid":false,"given":"Tamsin S.","family":"Barnes","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1939-1676.2011.0695.x","article-title":"Mortality in North American dogs from 1984 to 2004: An investigation into age, size, and breed-related causes of death","volume":"25","author":"Fleming","year":"2011","journal-title":"J. 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