{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:08:39Z","timestamp":1788037719215,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Most of the pathologies that affect hedgehogs are diagnosed postmortem; thus, it is essential to share knowledge between clinicians and pathologists in order to recognize predispositions to diseases and to establish adequate diagnostic and therapeutic plans. This study aimed to describe the most relevant postmortem pathological conditions in a group of six rescued African pygmy hedgehogs, performed over a period of four months. Hedgehogs were submitted to necropsy examinations and subsequent histopathological analyses. Microscopically, all the studied hedgehogs revealed alterations in one or more organ systems. Although a significant and diverse number of pathological conditions were obtained, this study focused on less common or more relevant pathologies found in African pygmy hedgehogs\u2014namely, wobbly hedgehog syndrome, squamous cell carcinoma and mast cell tumors. Furthermore, this study constitutes the first report of Mycobacterium spp. in hedgehogs in Portugal, the second report of follicular thyroid carcinoma in an African pygmy hedgehog, the description of a lipoid pneumonia for the first time in this species and a lung adenocarcinoma\u2014a pathology rarely reported in African pygmy hedgehogs.<\/jats:p>","DOI":"10.3390\/ani12111361","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:50:22Z","timestamp":1653555022000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pathological Findings in African Pygmy Hedgehogs Admitted into a Portuguese Rehabilitation Center"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0699-2640","authenticated-orcid":false,"given":"Gabriela Fernandes","family":"Silva","sequence":"first","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, Porto University, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-2404","authenticated-orcid":false,"given":"Alexandra","family":"R\u00eama","sequence":"additional","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, Porto University, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, Porto University, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua J\u00falio Amaral de Carvalho Nr. 45, 4200-804 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-5283","authenticated-orcid":false,"given":"Maria dos Anjos","family":"Pires","sequence":"additional","affiliation":[{"name":"Center of Animal and Veterinary Sciences, University of Tr\u00e1s-os-Montes e Alto Douro, 5000-811 Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-6038","authenticated-orcid":false,"given":"Marian","family":"Taulescu","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"},{"name":"Synevovet Laboratory, Industriilor Street, No. 25, Chiajna, Ilfov County, 077040 Chiajna, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Amorim","sequence":"additional","affiliation":[{"name":"ICBAS-School of Medicine and Biomedical Sciences, Porto University, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua J\u00falio Amaral de Carvalho Nr. 45, 4200-804 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Amori, G. (2022, February 28). Erinaceus europaeus. The IUCN Red List of Threatened Species 2016, Available online: https:\/\/dx.doi.org\/10.2305\/IUCN.UK.2016-3.RLTS.T29650A2791303.en.","DOI":"10.2305\/IUCN.UK.2016-3.RLTS.T29650A2791303.en"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid1101.040752","article-title":"Hedgehog zoonoses","volume":"11","author":"Riley","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ruszkowski, J.J., Hetman, M., Turlewicz-Podbielska, H., and Pomorska-M\u00f3l, M. (2021). Hedgehogs as a potential source of zoonotic pathogens\u2014A review and an update of knowledge. Animals, 11.","DOI":"10.3390\/ani11061754"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cassola, F. (2022, February 28). Atelerix albiventris. The IUCN Red List of Threatened Species 2016, Available online: https:\/\/doi.org\/10.2305\/IUCN.UK.2016-3.RLTS.T40602A22324217.en.","DOI":"10.2305\/IUCN.UK.2016-3.RLTS.T40602A22324217.en"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Heatley, J.J. (2009). Hedgehogs. Manual-of-Exotic-Pet-Practice, Saunders Elsevier.","DOI":"10.1016\/B978-141600119-5.50019-6"},{"key":"ref_6","first-page":"32","article-title":"Retrospective study of disease occurrence in captive African Pygmy hedgehogs (Atelerix albiventris)","volume":"70","author":"Gardhouse","year":"2015","journal-title":"Isr. J. Vet. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cvex.2020.01.010","article-title":"Selected Emerging Diseases of Pet Hedgehogs","volume":"23","author":"Keeble","year":"2020","journal-title":"Vet. Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1292\/jvms.18-0238","article-title":"A retrospective study of disease incidence in African pygmy hedgehogs (Atelerix albiventris)","volume":"80","author":"Okada","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_9","unstructured":"Doss, G.A., and Carpenter, J.W. (2021, November 24). Diseases of Hedgehogs. Available online: https:\/\/www.msdvetmanual.com\/exotic-and-laboratory-animals\/hedgehogs\/diseases-of-hedgehogs."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ivey, E., and Carpenter, J.W. (2012). African Hedgehogs. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, Elsevier.","DOI":"10.1016\/B978-1-4160-6621-7.00030-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/0300985818768033","article-title":"The Pathology of Wobbly Hedgehog Syndrome","volume":"55","author":"Whitley","year":"2018","journal-title":"Vet. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cvex.2020.05.005","article-title":"Geriatric Hedgehogs","volume":"23","author":"Johnson","year":"2020","journal-title":"Vet. Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/1040638719878870","article-title":"Oral masses in African pygmy hedgehogs","volume":"31","author":"Torres","year":"2019","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.saep.2005.07.002","article-title":"A Review of Neoplasia in the Captive African Hedgehog","volume":"14","author":"Heatley","year":"2005","journal-title":"Semin. Avian Exot. Pet Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/jcpa.2000.0441","article-title":"Spontaneous tumours in captive African hedgehogs (Atelerix albiventris): A retrospective study","volume":"124","author":"Raymond","year":"2001","journal-title":"J. Comp. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jcpa.2020.11.003","article-title":"Non-tuberculous Mycobacterial Granulomatous Dermatitis in an African Pygmy Hedgehog (Atelerix albiventris)","volume":"182","author":"Blume","year":"2021","journal-title":"J. Comp. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cvex.2006.10.003","article-title":"Cytologic Diagnosis of Diseases of Hedgehogs","volume":"10","author":"Garner","year":"2007","journal-title":"Vet. Clin. N. Am. Exot. Anim. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/00480169.\/1995.35917","article-title":"Mycobacterium bovis infection in New Zealand hedgehogs (Erinaceus europaeus)","volume":"43","author":"Lugton","year":"1995","journal-title":"N. Z. Vet. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/00480169.2011.605747","article-title":"Mycobacterium avium subsp. paratuberculosis infection in wildlife on three deer farms with a history of Johne\u2019s disease","volume":"59","author":"Nugent","year":"2011","journal-title":"N. Z. Vet. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1111\/tbed.12306","article-title":"New Insights into Mycobacterium bovis Prevalence in Wild Mammals in Portugal","volume":"63","author":"Matos","year":"2016","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcpa.2020.09.013","article-title":"Eosinophilic Leukaemia and Systemic Mycobacterium marinum Infection in an African Pygmy Hedgehog (Atelerix albiventris)","volume":"181","author":"Nakamura","year":"2020","journal-title":"J. Comp. Pathol."},{"key":"ref_22","first-page":"1280","article-title":"Systemic Mycobacterium marinum infection in a European hedgehog","volume":"183","author":"Tappe","year":"1983","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.jepm.2005.11.010","article-title":"Wobbly Hedgehog Syndrome in African Pygmy Hedgehogs (Atelerix spp.)","volume":"15","author":"Graesser","year":"2006","journal-title":"J. Exot. Pet Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cvsm.2007.03.008","article-title":"Thyroid Tumors in Dogs and Cats","volume":"37","author":"Barber","year":"2007","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.jepm.2016.04.007","article-title":"Treatment of a Thyroid Tumor in an African Pygmy Hedgehog (Atelerix albiventris)","volume":"25","author":"LaRue","year":"2016","journal-title":"J. Exot. Pet Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1638\/1042-7260(2002)033[0392:TCCCIA]2.0.CO;2","article-title":"Thyroid C-cell carcinoma in an African pygmy hedgehog (Atelerix albiventris)","volume":"33","author":"Miller","year":"2002","journal-title":"J. Zoo Wildl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Scott-Moncrieff, J.C. (2015). Canine Thyroid Tumors and Hyperthyroidism. Canine and Feline Endocrinology, Saunders Elsevier Inc.. [4th ed.].","DOI":"10.1016\/B978-1-4557-4456-5.00005-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1532-950X.1995.tb01336.x","article-title":"A Comparison of Medullary Thyroid Carcinoma and Thyroid Adenocarcinoma in Dogs: A Retrospective Study of 38 Cases","volume":"24","author":"Carver","year":"1995","journal-title":"Vet. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s10646-012-1012-2","article-title":"Thyroid disruption in the lizard Podarcis bocagei exposed to a mixture of herbicides: A field study","volume":"22","author":"Bicho","year":"2012","journal-title":"Ecotoxicology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jcpa.2013.01.008","article-title":"Endogenous lipid pneumonia in an african grey parrot (Psittacus erithacus erithacus)","volume":"149","author":"Costa","year":"2013","journal-title":"J. Comp. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/jsap.13101","article-title":"Endogenous lipoid pneumonia associated with pulmonary neoplasia in three dogs","volume":"62","author":"Liuti","year":"2021","journal-title":"J. Small Anim. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(07)60530-3","article-title":"Endogenous lipoid pneumonia associated with primary sclerosing cholangitis","volume":"369","author":"Berghaus","year":"2007","journal-title":"Lancet"},{"key":"ref_33","first-page":"813","article-title":"Endogenous lipid pneumonia and what lies beneath","volume":"49","author":"Himsworth","year":"2008","journal-title":"Can. Veter. J. = La Rev. Veter. Can."},{"key":"ref_34","unstructured":"Cullen, J.M., and Brown, D.L. (2012). Hepatobiliary system and exocrine pancreas. Pathologic Basis of Veterinary Disease, Elsevier. [5th ed.]."},{"key":"ref_35","first-page":"371","article-title":"Metastatic mast cell tumour in African hedgehog: A case report","volume":"65","author":"Ciaputa","year":"2020","journal-title":"Vet. Med. (Praha)"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7589\/0090-3558-33.1.140","article-title":"Malignant mast cell tumor in an African hedgehog (Atelerix albiventris)","volume":"33","author":"Raymond","year":"1997","journal-title":"J. Wildl. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Toma, C., Balteanu, V.A., Tripon, S., Trifa, A., Rema, A., Amorim, I., Pop, R.M., Popa, R., Catoi, C., and Taulescu, M. (2020). Exogenous Jaagsiekte Sheep Retrovirus type 2 (exJSRV2) related to ovine pulmonary adenocarcinoma (OPA) in Romania: Prevalence, anatomical forms, pathological description, immunophenotyping and virus identification. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02521-1"},{"key":"ref_38","unstructured":"Dungworth, D.L., Hauser, B., Hahn, F.F., Wilson, D.W., Haenichen, T., and Harkema, J.R. (1999). WHO: Histological Classification of Tumors of the Respiratory System of Domestic Animals."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1439-0442.2005.00773.x","article-title":"Pulmonary adenosquamous carcinoma in a dog","volume":"52","author":"Sato","year":"2005","journal-title":"J. Vet. Medicine. A Physiol. Pathol. Clin. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/j.jepm.2014.11.003","article-title":"A retrospective study of the medical status on 63 african hedgehogs (Atelerix albiventris) at the taipei zoo from 2003 to 2011","volume":"24","year":"2015","journal-title":"J. Exot. Pet Med."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/11\/1361\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:19:01Z","timestamp":1760138341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/11\/1361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ani12111361"],"URL":"https:\/\/doi.org\/10.3390\/ani12111361","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}