{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:50:13Z","timestamp":1789753813384,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Guangdong Province","award":["2020A03025"],"award-info":[{"award-number":["2020A03025"]}]},{"name":"Fundamental Research Funds for the Guangdong Province","award":["2019KJ127"],"award-info":[{"award-number":["2019KJ127"]}]},{"name":"Fundamental Research Funds for the Guangdong Province","award":["2021003"],"award-info":[{"award-number":["2021003"]}]},{"name":"Fundamental Research Funds for the Agriculture and Rural Affairs of Guangdong Department","award":["2020A03025"],"award-info":[{"award-number":["2020A03025"]}]},{"name":"Fundamental Research Funds for the Agriculture and Rural Affairs of Guangdong Department","award":["2019KJ127"],"award-info":[{"award-number":["2019KJ127"]}]},{"name":"Fundamental Research Funds for the Agriculture and Rural Affairs of Guangdong Department","award":["2021003"],"award-info":[{"award-number":["2021003"]}]},{"name":"Fundamental Research Funds for Education Department of Guangdong","award":["2020A03025"],"award-info":[{"award-number":["2020A03025"]}]},{"name":"Fundamental Research Funds for Education Department of Guangdong","award":["2019KJ127"],"award-info":[{"award-number":["2019KJ127"]}]},{"name":"Fundamental Research Funds for Education Department of Guangdong","award":["2021003"],"award-info":[{"award-number":["2021003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The purpose of this study was to evaluate the effects of fucoidan supplementation on serum biochemical parameters, small intestinal barrier function, and cecal microbiota of weaned goat kids. A total of 60 2-month-old weaned castrated male goat kids (Chuanzhong black goat) were used in this 30-day experiment. The goat kids were randomly divided into four groups: a control group (CON) fed the basal diet, and three other groups supplemented with 0.1%, 0.3%, and 0.5% fucoidan in the basal diet (denoted as F1, F2, and F3 groups, respectively). The results indicated that dietary fucoidan supplementation decreased (p &lt; 0.05) the activity of lactate dehydrogenase (LDH) and the content of glucose (GLU) as measured on day 15. As measured on day 30, dietary fucoidan increased (p &lt; 0.05) the content of total protein (TP) and decreased the activity of aspartate aminotransferase (AST), and supplementation with 0.3% and 0.5% fucoidan decreased (p &lt; 0.05) the activity of LDH. Dietary fucoidan decreased (p &lt; 0.05) the content of D-lactic acid (D-LA) and the activity of diamine oxidase (DAO). Dietary fucoidan increased (p &lt; 0.05) the activity of catalase (CAT) in the duodenum. Dietary 0.3% and 0.5% fucoidan enhanced (p &lt; 0.05) the activity of glutathione peroxidase (GSH-Px) in the ileum, the activity of total superoxide dismutase (T-SOD) in the jejunum and ileum, and the activity of CAT in the ileum. Dietary 0.3% and 0.5% fucoidan reduced the contents of malondialdehyde (MDA) in the duodenum, jejunum, and ileum and the content of hydrogen peroxide (H2O2) in the duodenum. Dietary fucoidan increased (p &lt; 0.05) the content of secretory immunoglobulin A (sIgA) in the duodenum. Supplementation of 0.3% and 0.5% fucoidan upregulated (p &lt; 0.05) the gene expression of ZO-1 and claudin-1 in the duodenum, jejunum, and ileum, and dietary supplementation of 0.3% and 0.5% fucoidan upregulated (p &lt; 0.05) the gene expression of occludin in the jejunum and ileum. The 16S rRNA high-throughput sequencing results showed that at the phylum level, dietary fucoidan increased (p &lt; 0.05) the abundance of Bacteroidetes while decreasing (p &lt; 0.05) the abundance of Firmicutes. At the genus level, dietary 0.3% and 0.5% fucoidan increased (p &lt; 0.05) the abundances of Unspecified_Ruminococcaceae, Unspecified_Bacteroidale, Unspecified_Clostridiales, and Akkermansia. In conclusion, dietary fucoidan supplementation had positive effects on intestinal permeability, antioxidant capacity, immunity function, tight junctions, and the cecal microflora balance in weaned goat kids.<\/jats:p>","DOI":"10.3390\/ani12121591","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T01:43:27Z","timestamp":1655775807000},"page":"1591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Dietary Fucoidan Supplementation on Serum Biochemical Parameters, Small Intestinal Barrier Function, and Cecal Microbiota of Weaned Goat Kids"],"prefix":"10.3390","volume":"12","author":[{"given":"Weiguang","family":"Yang","sequence":"first","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhen","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"},{"name":"The Key Laboratory of Animal Resources and Breed Innovation in Western Guangdong Province, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Coastal Agriculture Science, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Han, Y.S., Tang, C.H., Li, Y., Yu, Y.N., Zhan, T.F., Zhao, Q.Y., and Zhang, J.M. 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