{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:54:09Z","timestamp":1771916049920,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","award":["141437"],"award-info":[{"award-number":["141437"]}]},{"name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"European Union","award":["141437"],"award-info":[{"award-number":["141437"]}]},{"name":"European Union","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]},{"name":"European Social Fund","award":["141437"],"award-info":[{"award-number":["141437"]}]},{"name":"European Social Fund","award":["EFOP-3.6.3-VEKOP-16-2017-00005"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Here we revise circumstances of non-infectious causes in which the uterus may be associated with pregnancy loss during the late embryo\/early fetal period (following a positive pregnancy diagnosis in lactating dairy cows). As the uterine size increases with parity and pregnant heifers with no detrimental effects of a previous parturition, a primigravid uterus is proposed as a reference for identifying risk factors that negatively influence pregnancy in lactating cows. Cows suffering placenta retention or with a large uterus at insemination were selected as topics for this revision. Retained placenta, that occurs around parturition, has a long-lasting influence on subsequent pregnancy loss. Although retained placenta is a particularly predisposing factor for uterine infection, farm conditions along with cow factors of non-infectious cause and their interactions have been identified as main factors favoring this disorder. A large uterus (cervix and uterine horns lying outside the pelvic cavity) with no detectable abnormalities has been associated with low fertility and with a greater incidence of pregnancy loss. A large reproductive tract may well derive from an inadequate uterine involution. Therefore, peripartum management and strategies to reduce the incidence of uterine disorders should reduce their associated financial losses in the herds.<\/jats:p>","DOI":"10.3390\/ani12151873","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:53:45Z","timestamp":1658494425000},"page":"1873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Uterus as an Influencing Factor for Late Embryo\/Early Fetal Loss\u2014A Clinical Update"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-857X","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Szel\u00e9nyi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Farm Animal Clinic, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Animal Husbandry and Welfare, Hungarian University of Agricultural and Life Sciences, 2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-173X","authenticated-orcid":false,"given":"Ott\u00f3","family":"Szenci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Farm Animal Clinic, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1413-3862","authenticated-orcid":false,"given":"Fernando","family":"Lopez-Gatius","sequence":"additional","affiliation":[{"name":"Transfer in Bovine Reproduction SLu, 22300 Barbastro, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","first-page":"167","article-title":"Late embryo and early fetal mortality in the cow","volume":"65","author":"Ball","year":"1997","journal-title":"Anim. 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