{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:00:46Z","timestamp":1791410446985,"version":"4.3.3"},"reference-count":121,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Myrothamnus flabellifolius (Welw.) is used in African traditional medicine for the treatment of depression and mental disorder, asthma, infectious diseases, respiratory, inflammation, epilepsy, heart, wound, backaches, diabetes, kidney ailments, hypertension, hemorrhoids, gingivitis, shingles, stroke, and skins conditions. The effectiveness of M. flabellifolius is due to the presence of several secondary metabolites that have demonstrated efficacy in other cell and animal models. These metabolites are key in cell regulation and function and have potential use in animal production due to antimicrobial and antioxidant properties, for an improvement in growth performance, feed quality and palatability, gut microbial environment, function, and animal health. The purpose of this review is to provide a detailed account on the potential use of M. flabellifolius in animal nutrition. Limitations towards the use of this plant in animal nutrition, including toxicity, economic, and financial issues are discussed. Finally, novel strategies and technologies, e.g., microencapsulation, microbial fermentation, and essential oil extraction, used to unlock and improve nutrient bioaccessibility and bioavailability are clearly discussed towards the potential use of M. flabellifolius as a phytogenic additive in animal diets.<\/jats:p>","DOI":"10.3390\/ani12151973","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:52:01Z","timestamp":1659559921000},"page":"1973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring the Potential of Myrothamnus flabellifolius Welw. (Resurrection Tree) as a Phytogenic Feed Additive in Animal Nutrition"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-9025","authenticated-orcid":false,"given":"Carlos Wyson Tawanda","family":"Nantapo","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, School of Agricultural Sciences, Faculty of Agriculture, Science and Technology, North-West University, P Bag X 2046, Mmabatho 2735, South Africa"},{"name":"Food Security and Safety Niche Area, Faculty of Agriculture, Science and Technology, North-West University, P Bag X 2046, Mmabatho 2735, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-5797","authenticated-orcid":false,"given":"Upenyu","family":"Marume","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, School of Agricultural Sciences, Faculty of Agriculture, Science and Technology, North-West University, P Bag X 2046, Mmabatho 2735, South Africa"},{"name":"Food Security and Safety Niche Area, Faculty of Agriculture, Science and Technology, North-West University, P Bag X 2046, Mmabatho 2735, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/BJ20040499","article-title":"The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation","volume":"385","author":"Moore","year":"2004","journal-title":"Biochem. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s10886-005-8396-x","article-title":"The South African and Namibian Populations of the Resurrection Plant Myrothamnus flabellifolius are Genetically Distinct and Display Variation in Their Galloylquinic Acid Composition","volume":"31","author":"Moore","year":"2005","journal-title":"J. Chem. Ecol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bentley, J., Moore, J.P., and Farrant, J.M. (2019). Metabolomic profiling of the desiccation-tolerant medicinal shrub Myrothamnus flabellifolia indicates phenolic variability across its natural habitat: Implications for tea and cosmetics production. Molecules, 24.","DOI":"10.3390\/molecules24071240"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.phytochem.2018.12.016","article-title":"Metabolomics as a complement to phylogenetics for assessing intraspecific boundaries in the desiccation-tolerant medicinal shrub Myrothamnus flabellifolia (Myrothamnaceae)","volume":"159","author":"Bentley","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0176-1617(00)80217-5","article-title":"Isolation and Characterisation of Chloroplasts from Myrothamnus flabellifolius Welw","volume":"156","author":"Koonjul","year":"2000","journal-title":"J. Plant Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1080\/14786419.2012.665916","article-title":"In vitro biological activities of the essential oil from the \u2018resurrection plant\u2019 Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar","volume":"26","author":"Nicoletti","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Erhabor, J.O., Komakech, R., Kang, Y., Tang, M., and Matsabisa, M.G. (2020). Ethnopharmacological importance and medical applications of Myrothamnus flabellifolius Welw. (Myrothamnaceae)\u2014A review. J. Ethnopharmacol., 252.","DOI":"10.1016\/j.jep.2020.112576"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0254-6299(16)30464-1","article-title":"The composition and antimicrobial activity of the essential oil of the resurrection plant Myrothamnus flabellifolius","volume":"68","author":"Viljoen","year":"2002","journal-title":"S. Afr. J. Bot."},{"key":"ref_9","first-page":"5460","article-title":"Antioxidant activities of crude extracts from medicinal plants used by diabetic patients in Eastern Botswana","volume":"6","author":"Motlhanka","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1746-4269-9-31","article-title":"Traditional use of medicinal plants in south-central Zimbabwe: Review and perspectives","volume":"9","author":"Maroyi","year":"2013","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chaturvedi, P., Kwape, T.E., and Majinda, R.R.T. (2016). Antioxidant and antidiabetic potential of Myrothamnus flabellifolius found in Botswana. Cogent. Biol., 2.","DOI":"10.1080\/23312025.2016.1275403"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jpn.12579","article-title":"Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals","volume":"101","author":"Gessner","year":"2017","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.36380\/jwpr.2021.33","article-title":"Growth Performance and Nutrient Digestibility in Broiler Chickens Fed with an Encapsulated Blend of a Phytogenic Feed Additive","volume":"11","author":"Syed","year":"2021","journal-title":"J. World\u2019s Poult. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17R","DOI":"10.1093\/glycob\/cwg047","article-title":"New insights on trehalose: A multifunctional molecule","volume":"13","author":"Elbein","year":"2003","journal-title":"Glycobiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5897\/JMPR2017.6518","article-title":"A novel anti-triple negative breast cancer compound isolated from medicinal herb Myrothamnus flabellifolius","volume":"12","author":"Brar","year":"2018","journal-title":"J. Med. Plants Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13026","DOI":"10.1111\/jfbc.13026","article-title":"Evaluation of the nutritional composition of Myrothamnus flabellifolius (Welw.) herbal tea and its protective effect against oxidative hepatic cell injury","volume":"43","author":"Chukwuma","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.fitote.2016.08.013","article-title":"Qualitative and quantitative phytochemical characterization of Myrothamnus flabellifolia Welw","volume":"114","author":"Engelhardt","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-313X.1998.00140.x","article-title":"Sensing trehalose biosynthesis in plants","volume":"14","author":"Goddijn","year":"1998","journal-title":"Plant J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.biotechadv.2014.03.005","article-title":"Natural products from resurrection plants: Potential for medical applications","volume":"32","author":"Gechev","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1097-2765(00)80064-7","article-title":"Multiple effects of trehalose on protein folding in vitro and in vivo","volume":"1","author":"Singer","year":"1998","journal-title":"Mol. Cell."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1134\/S0026261714020064","article-title":"Trehalose: Chemical Structure, Biological Functions, and practical application","volume":"83","author":"Feofilova","year":"2014","journal-title":"Microbiology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Colaco, C., and Roser, B. (1994). Trehalose-a multifunctional additive for food preservation. Food Packaging and Preservation, Springer.","DOI":"10.1007\/978-1-4615-2173-0_7"},{"key":"ref_23","first-page":"58","article-title":"Effect of Trehalose on the Growth and Carcass Performance of AA Broilers","volume":"11","author":"Jun","year":"2009","journal-title":"J. Agric. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ruangpanit, Y., Matsushita, K., Mukai, K., and Kikusato, M. (2020). Effect of trehalose supplementation on growth performance and intestinal morphology in broiler chickens. Vet. Anim. Sci., 10.","DOI":"10.1016\/j.vas.2020.100142"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0176-1617(11)81257-5","article-title":"The occurrence of trehalose in the leaves of the desiccation-tolerant angiosperm Myrothamnus flabellifolius Welw","volume":"142","author":"Drennan","year":"1993","journal-title":"J. Plant Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.3168\/jds.2009-2961","article-title":"Supplementation of the diet of dairy cows with trehalose results in milk with low lipid peroxide and high antioxidant content","volume":"93","author":"Aoki","year":"2010","journal-title":"J. Dairy Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/asj.12414","article-title":"Molecular nutrition: Interaction of nutrients, gene regulations and performances","volume":"87","author":"Sato","year":"2016","journal-title":"Anim. Sci. J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Miura, H., Mukai, K., Sudo, K., Haga, S., Suzuki, Y., Kobayashi, Y., and Koike, S. (2021). Effect of trehalose supplementation in milk replacer on the incidence of diarrhea and fecal microbiota in preweaned calves. J. Anim. Sci., 99.","DOI":"10.1093\/jas\/skab012"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1472-765X.2007.02167.x","article-title":"Effects of prebiotic oligosaccharides and trehalose on growth and production of bacteriocins by lactic acid bacteria","volume":"45","author":"Chen","year":"2007","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1071\/AN11055","article-title":"Minimising weight loss in new broiler hatchlings through early feeding of simple sugars","volume":"51","author":"Bhuiyan","year":"2011","journal-title":"Anim. Prod. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/jsfa.925","article-title":"Intestinal structure and function of broiler chickens on diets supplemented with a mannan oligosaccharide","volume":"81","author":"Iji","year":"2001","journal-title":"J. Sci. Food Agric."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/00071668.2016.1166475","article-title":"Effects of trehalose supplementation on the growth performance and intestinal innate immunity of juvenile chicks","volume":"57","author":"Kikusato","year":"2016","journal-title":"Br. Poult. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41419-018-0749-9","article-title":"Mechanism of neuroprotection by trehalose: Controversy surrounding autophagy induction","volume":"9","author":"Lee","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1399-3054.1993.tb00146.x","article-title":"The unusual sugar composition in leaves of the resurrection plant Myrothamnus flabellifolia","volume":"87","author":"Bianchi","year":"1993","journal-title":"Physiol. Plant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.31989\/ffhd.v5i12.222","article-title":"Glucosylglycerol on performance of prebiotic potential","volume":"5","author":"Sawangwan","year":"2015","journal-title":"Funct. Foods Health Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jbiotec.2017.01.019","article-title":"Production of glucosyl glycerol by immobilized sucrose phosphorylase: Options for enzyme fixation on a solid support and application in microscale flow format","volume":"257","author":"Bolivar","year":"2017","journal-title":"J. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s12010-014-0889-z","article-title":"Biosynthesis of glucosyl glycerol, a compatible solute, using intermolecular transglycosylation activity of amylosucrase from Methylobacillus flagellatus KT","volume":"173","author":"Jeong","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/EBC20200134","article-title":"Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being","volume":"65","author":"Wolf","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0723-2020(00)80043-0","article-title":"Salt adaptation in pseudomonads: Characterization of glucosylglycerol-synthesizing isolates from brackish coastal waters and the rhizosphere","volume":"23","author":"Mikkat","year":"2000","journal-title":"Syst. Appl. Microbiol."},{"key":"ref_40","first-page":"59","article-title":"Effect of apple cider vinegar on glycemic control, hyperlipidemia and control on body weight in type 2 diabetes patients","volume":"8","author":"Kausar","year":"2019","journal-title":"Int. J. Med. Res. Health Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Rastegari, H., Jazini, H., Ghaziaskar, H.S., and Yalpani, M. (2019). Applications of biodiesel by-products. Biodiesel, Springer.","DOI":"10.1007\/978-3-030-00985-4_5"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Amer, S.A., Naser, M.A.F., Abdel-Wareth, A.A.A., Saleh, A.A., Elsayed, S.A.M., and Metwally, A.E. (2020). Effect of dietary supplementation of alpha-galactosidase on the growth performance, ileal digestibility, intestinal morphology, and biochemical parameters in broiler chickens. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02359-7"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.carbpol.2009.03.016","article-title":"Health benefit application of functional oligosaccharides","volume":"77","author":"Qiang","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s11274-010-0558-5","article-title":"Functional oligosaccharides: Production, properties and applications","volume":"27","author":"Patel","year":"2011","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1017\/S1751731116000173","article-title":"Influence of different prebiotics and mode of their administration on broiler chicken performance","volume":"10","author":"Bednarczyk","year":"2016","journal-title":"Animal"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/jpn.13182","article-title":"Microstructure of the small intestine in broiler chickens fed a diet with probiotic or synbiotic supplementation","volume":"103","author":"Bogucka","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fsi.2017.11.001","article-title":"Effects of dietary raffinose on growth, non-specific immunity, intestinal morphology and microbiome of juvenile hybrid sturgeon (Acipenser baeri Brandt\u2640\u00d7 A. schrenckii Brandt\u2642)","volume":"72","author":"Xu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/00071660600827708","article-title":"Effect of stachyose supplementation on growth performance, nutrient digestibility and caecal fermentation characteristics in broilers","volume":"47","author":"Jiang","year":"2006","journal-title":"Br. Poult. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phytol.2015.05.015","article-title":"The significance of arbutin and its derivatives in therapy and cosmetics","volume":"13","author":"Migas","year":"2015","journal-title":"Phytochem. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Masumoto, S., Nakamura, Y., and Haginaka, J. (2021). Molecularly imprinted polymers for arbutin and rutin by modified precipitation polymerization and their application for selective extraction of rutin in nutritional supplements. J. Pharm. Biomed. Anal., 205.","DOI":"10.1016\/j.jpba.2021.114294"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Bonifacio, M.A., Cerqueni, G., Cometa, S., Licini, C., Sabbatini, L., Mattioli-Belmonte, M., and De Giglio, E. (2020). Insights into arbutin effects on bone cells: Towards the development of antioxidant titanium implants. Antioxidants, 9.","DOI":"10.3390\/antiox9070579"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/BF02027727","article-title":"Effect of simple phenolic compounds of heather (Calluna vulgaris) on rumen microbial activity in vitro","volume":"22","author":"Murray","year":"1996","journal-title":"J. Chem. Ecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2306\/scienceasia1513-1874.2018.44.170","article-title":"Phytochemicals, cytotoxicity, and genotoxicity of three Artocarpus species reveal arbutin in A. lacucha","volume":"44","author":"Noikotra","year":"2018","journal-title":"Sci. Asia"},{"key":"ref_54","first-page":"71","article-title":"Qualitative and quantitative analysis of phytochemical compounds in Namibian Myrothamnus flabellifolius Phytochemical Compounds in M. flabellifolius","volume":"5","author":"Cheikhyoussef","year":"2015","journal-title":"Int. Sci. Technol. J. Namibia"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Abdelli, N., Sol, D., and Francisco, P. (2021). Phytogenic Feed Additives in Poultry: Achievements, Prospective and Challenges. Animals, 11.","DOI":"10.3390\/ani11123471"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00580-017-2464-9","article-title":"Kinetics of inhibitory action of Myrothamnus flabellifolius Welw. on the activities of \u03b1-amylase and \u03b1-glucosidase","volume":"26","author":"Ajao","year":"2017","journal-title":"Comp. Clin. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.saa.2014.04.052","article-title":"Spectroscopic studies on the antioxidant activity of ellagic acid","volume":"130","author":"Kilic","year":"2014","journal-title":"Spectrochim. Acta Part A Mol. Spectrosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/jn\/133.9.2802","article-title":"The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors","volume":"133","author":"Cermak","year":"2003","journal-title":"J. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jpn.12070","article-title":"Polyphenol compounds in the chicken\/animal diet: From the past to the future","volume":"98","author":"Surai","year":"2014","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3109\/14756366.2011.566220","article-title":"Inhibition of HIV-1 and M-MLV reverse transcriptases by a major polyphenol (3,4,5 tri-O-galloylquinic acid) present in the leaves of the South African resurrection plant, Myrothamnus flabellifolia","volume":"26","author":"Moore","year":"2011","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/13102818.2021.1942208","article-title":"Investigation on the active ingredient and mechanism of Cannabis sativa L. for treating epilepsy based on network pharmacology","volume":"35","author":"Li","year":"2021","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cbi.2016.11.028","article-title":"Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity","volume":"261","author":"Motta","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bjp.2015.05.005","article-title":"Copaifera langsdorffii: Evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves","volume":"25","author":"Lemos","year":"2015","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/bph.12194","article-title":"Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells","volume":"169","author":"Bardy","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1021\/acsomega.0c01818","article-title":"Therapeutic potential of quercetin: New insights and perspectives for human health","volume":"5","author":"Salehi","year":"2020","journal-title":"ACS Omega"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3389\/fphar.2015.00259","article-title":"Syzygium cumini (L.) skeels: A prominent source of bioactive molecules against cardiometabolic diseases","volume":"6","author":"Chagas","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ahmadipour, B., Hassanpour, H., and Khajali, F. (2018). Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1561-6"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ying, L., Chaudhry, M.T., Xiao, F., Mao, Y., Wang, M., Wang, B., Wang, S., and Li, Y. (2020). The effects and mechanism of quercetin dietary supplementation in streptozotocin-induced hyperglycemic arbor acre broilers. Oxidative Med. Cell. Longev., 10.","DOI":"10.1155\/2020\/9585047"},{"key":"ref_69","first-page":"247","article-title":"Effect of dietary supplementation with extracts of rosemary, olive leaves, pine bark and quercetin on selected performance indices of broiler chickens and microbiological status of their ileum","volume":"75","author":"Sierzant","year":"2019","journal-title":"Med. Weter"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10412905.2012.676801","article-title":"Phytochemical investigation of the essential oil from the \u2018resurrection plant\u2019 Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar","volume":"24","author":"Rasoanaivo","year":"2012","journal-title":"J. Essent. Oil Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1080\/14786419.2014.994213","article-title":"Antioxidant activity and cytotoxicity on tumour cells of the essential oil from Cedronella canariensis var. canariensis (L.) Webb & Berthel.(Lamiaceae)","volume":"29","author":"Zorzetto","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Cervantes, M., P\u00e9rez-Alonso, M.J., Blanco-Salas, J., Soria, A.C., and Ruiz-T\u00e9llez, T. (2019). Analysis of the essential oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a contribution to reinforce its ethnobotanical use. Forests, 10.","DOI":"10.3390\/f10070539"},{"key":"ref_73","first-page":"889","article-title":"Recent developments in usage of natural antioxidants to improve chicken meat production and quality","volume":"19","author":"Fotina","year":"2013","journal-title":"Bulg. J. Agric. Sci."},{"key":"ref_74","first-page":"2038","article-title":"The Efficacy of Phytogenic Feed Additives in Poultry Production: A Review","volume":"7","author":"Oladeji","year":"2019","journal-title":"Turk. J. Agric.-Food Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.sajb.2015.06.006","article-title":"Determination and comparison of phenolic compound content and antioxidant activity of selected local Zimbabwean herbal teas with exotic Aspalathus linearis","volume":"100","author":"Bhebhe","year":"2015","journal-title":"S. Afr. J. Bot."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/10412905.2006.12067124","article-title":"A comparative investigation of the antimicrobial properties of indigenous South African aromatic plants with popular commercially available essential oils","volume":"18","author":"Viljoen","year":"2006","journal-title":"J. Essent. Oil Res."},{"key":"ref_77","first-page":"1401","article-title":"Encapsulation of Essential Oils within a Polymeric Liposomal Formulation for Enhancement of Antimicrobial Efficacy","volume":"5","author":"Parry","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Favaretto, J.A., Alba, D.F., Marchiori, M.S., Marcon, H.J., Souza, C.F., Baldissera, M.D., Bianchi, A.E., Zanluchi, M., Klein, B., and Wagner, R. (2020). Supplementation with a blend based on micro-encapsulated carvacrol, thymol, and cinnamaldehyde in lambs feed inhibits immune cells and improves growth performance. Livest. Sci., 240.","DOI":"10.1016\/j.livsci.2020.104144"},{"key":"ref_79","first-page":"49","article-title":"Phytogenics as feed additives in poultry production: A review","volume":"3","author":"Yitbarek","year":"2015","journal-title":"Int. J. Extensive Res."},{"key":"ref_80","first-page":"234","article-title":"Application of herbs and phytogenic feed additives in poultry production\u2014A Review","volume":"2","author":"Alloui","year":"2014","journal-title":"Glob. J. Anim. Sci. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/pathogens4010137","article-title":"Phytogenic Compounds as Alternatives to In-Feed Antibiotics: Potentials and Challenges in Application","volume":"4","author":"Yang","year":"2015","journal-title":"Pathogens"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.sajb.2010.10.003","article-title":"An ultrastructural investigation of the surface microbiota present on the leaves and reproductive structures of the resurrection plant Myrothamnus flabellifolia","volume":"77","author":"Moore","year":"2011","journal-title":"S. Afr. J. Bot."},{"key":"ref_83","first-page":"157","article-title":"Encapsulated Fermeherbafit Bioavailability and the Application to Broilers","volume":"9","author":"Iriyanti","year":"2019","journal-title":"J. Agric. Sci. Technol. A"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bacova, K., Eglseer, K.Z., R\u00e4uber, G.K., Chrastinova, L., Laukova, A., Takacsova, M., Simonova, M.P., and Placha, L. (2021). Effect of Sustained Administration of Thymol on Its Bioaccessibility and Bioavailability in Rabbits. Animals, 11.","DOI":"10.3390\/ani11092595"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Alkhalidy, H., Wang, Y., and Liu, D. (2018). Dietary flavonoids in the prevention of T2D: An overview. Nutrients, 10.","DOI":"10.3390\/nu10040438"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1039\/C7FO00574A","article-title":"Bioaccessibility and bioavailability of phenolic compounds in bread: A review","volume":"8","author":"Angelino","year":"2017","journal-title":"Food Funct."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cbi.2007.06.016","article-title":"Measuring and modeling bioavailability in in vitro systems","volume":"2","author":"Kramer","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Weichselbaum, E., and Buttriss, J.L. (2010). Polyphenols in the Diet, Wiley Online Library.","DOI":"10.1111\/j.1467-3010.2010.01821.x"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/109662000416311","article-title":"Chocolate: Modern science investigates an ancient medicine","volume":"3","author":"Scalbert","year":"2000","journal-title":"J. Med. Food"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.meatsci.2016.06.017","article-title":"Effect of essential oils on meat and fat qualities of crossbred young bulls finished in feedlots","volume":"121","author":"Rivaroli","year":"2016","journal-title":"Meat Sci."},{"key":"ref_91","first-page":"982576","article-title":"Essential oil constituents and yields from leaves of Blepharocalyx salicifolius (Kunt) O. Berg and Myracrodruon urundeuva (Allem\u00e3o) collected during daytime","volume":"2014","author":"Benedito","year":"2014","journal-title":"Int. J. For. Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Liu, M., Luo, F., Qing, Z., Yang, H., Liu, X., Yang, Z., and Zeng, J. (2020). Chemical composition and bioactivity of essential oil of ten Labiatae species. Molecules, 25.","DOI":"10.3390\/molecules25204862"},{"key":"ref_93","unstructured":"Mandeya, K. (2018). Extraction of Essential oils from Myrothamnus Flabellifolious and Their Application as Beef Oxidative Stabilizers. [Ph.D. Thesis, Bindura University of Science Education]."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1002\/fsn3.846","article-title":"Fermentation and germination improve nutritional value of cereals and legumes through activation of endogenous enzymes","volume":"6","author":"Nkhata","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10","DOI":"10.11118\/actaun.2021.011","article-title":"Hematological and Intestinal Responses of Broilers to Dietary Supplementations of Lactic Fermented Turmeric, Black Pepper or a Mixture of Both","volume":"69","author":"Sugiharto","year":"2021","journal-title":"Acta Univ. Agric. Silvic. Mendel. Brun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13568-018-0682-4","article-title":"Fermented Astragalus in diet altered the composition of fecal microbiota in broiler chickens","volume":"8","author":"Qiao","year":"2018","journal-title":"AMB Express"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/00071668.2015.1030590","article-title":"Effects of dietary supplementation with fermented ginkgo leaves on antioxidant capacity, intestinal morphology and microbial ecology in broiler chicks","volume":"56","author":"Zhang","year":"2015","journal-title":"Br. Poult. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.livsci.2012.04.018","article-title":"Effect of feeding Aspergillus niger-fermented Ginkgo biloba-leaves on growth, small intestinal structure and function of broiler chicks","volume":"147","author":"Zhang","year":"2012","journal-title":"Livest. Sci."},{"key":"ref_99","first-page":"824","article-title":"Effect of fermentation temperature and time on the chemical composition of bush tea (Athrixia phylicoides DC.)","volume":"4","author":"Hlahla","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4141\/cjas2013-144","article-title":"Review: Chinese herbs as alternatives to antibiotics in feed for swine and poultry production: Potential and challenges in application","volume":"94","author":"Gong","year":"2014","journal-title":"Can. J. Anim. Sci."},{"key":"ref_101","first-page":"19","article-title":"Phytogenic Feed Additives as an Alternative to Antibiotic Growth Promoters in Poultry Nutrition","volume":"8","author":"Mandey","year":"2021","journal-title":"Adv. Stud. 21st Century Anim. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1080\/00071668.2019.1622078","article-title":"Chitosan nano-encapsulation improves the effects of mint, thyme, and cinnamon essential oils in broiler chickens","volume":"60","author":"Nouri","year":"2019","journal-title":"Br. Poult. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/PAVSNNR20094033","article-title":"Encapsulation technologies for functional foods and nutraceutical product development","volume":"4","author":"Kailasapathy","year":"2009","journal-title":"CAB Rev."},{"key":"ref_104","unstructured":"G\u00f6kmen, S., \u00dcniversitesi, K.M., and Palamutoglu, R. (2022, February 07). Applications of Encapsulation in Food Industry Determination of the Effects of Various Levels of Lemon and Pomegranate Peels on the Microbiological Properties of Cig K\u00f6fte View Project Author View Project. Available online: www.teknolojikarastirmalar.com."},{"key":"ref_105","first-page":"624","article-title":"Encapsulation Methods and Use in Animal Nutrition","volume":"32","author":"Temiz","year":"2018","journal-title":"Selcuk J. Agric. Food Sci."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Huesca-Uri\u00f3stegui, K., Garc\u00eda-Valderrama, E.J., Gutierrez-Uribe, J.A., Antunes-Ricardo, M., and Guajardo-Flores, D. (2022). Nanofiber Systems as Herbal Bioactive Compounds Carriers: Current Applications in Healthcare. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14010191"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/00914037.2017.1354206","article-title":"Turmeric nanofiber-encapsulated natural product formulation act as a phytogenic feed additive\u2014A study in broilers on growth performance, biochemical indices of blood, and E. coli in cecum","volume":"67","author":"Gopi","year":"2018","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Tolve, R., Tchuenbou-magaia, F., Di, M., Carmela, M., Scarpa, T., and Galgano, F. (2021). Encapsulation of bioactive compounds for the formulation of functional animal feeds: The biofortification of derivate foods. Anim. Feed Sci. Technol., 279.","DOI":"10.1016\/j.anifeedsci.2021.115036"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3382\/ps\/pev368","article-title":"Effect of supplementation of phytogenic feed additives (powdered vs. encapsulated) on performance and nutrient digestibility in broiler chickens","volume":"95","author":"Hafeez","year":"2016","journal-title":"Poult. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Silva, S., Almeida, D., Bou\u00e7a, G., Silva, M., Maria, D., Freire, G., Moura-Nunesd, N., Monteiro, M., and Perrone, D. (2020). Bioaccessibility and gut metabolism of phenolic compounds of breads added with green co ff ee infusion and enzymatically bioprocessed. Food Chem., 333.","DOI":"10.1016\/j.foodchem.2020.127473"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T.T., Le, T.V.A., Dang, N.N., Nguyen, D.C., Nguyen, P.T.N., Tran, T.T., Nguyen, Q.V., Bach, L.G., and Nguyen Pham, D.T. (2021). Microencapsulation of Essential Oils by Spray-Drying and Influencing Factors. J. Food Qual., 2021.","DOI":"10.1155\/2021\/5525879"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Bag, A., and Chattopadhyay, R.R. (2015). Evaluation of synergistic antibacterial and antioxidant efficacy of essential oils of spices and herbs in combination. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131321"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Nguyen, D.H., Seok, W.J., and Kim, I.H. (2020). Organic acids mixture as a dietary additive for pigs\u2014A review. Animals, 10.","DOI":"10.3390\/ani10060952"},{"key":"ref_114","first-page":"181","article-title":"Herbal extracts and organic acids as natural feed additives in pig diets","volume":"43","author":"Costa","year":"2013","journal-title":"S. Afr. J. Anim. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Sawicki, R., Golus, J., Przekora, A., Ludwiczuk, A., Sieniawska, E., and Ginalska, G. (2018). Antimycobacterial activity of cinnamaldehyde in a Mycobacterium tuberculosis (H37Ra) model. Molecules, 23.","DOI":"10.3390\/molecules23092381"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.gaost.2019.03.001","article-title":"Role of essential oils in food safety: Antimicrobial and antioxidant applications","volume":"2","author":"Bhavaniramya","year":"2019","journal-title":"Grain Oil Sci. Technol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/asj.12782","article-title":"Effects of a protected inclusion of organic acids and essential oils as antibiotic growth promoter alternative on growth performance, intestinal morphology and gut microflora in broilers","volume":"88","author":"Liu","year":"2017","journal-title":"Anim. Sci. J."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"El-Azrak, K.E.-D.M., Morsy, A.S., Soltan, Y.A., Hashem, N.M., and Sallam, S.M.A. (2021). Impact of specific essential oils blend on milk production, serum biochemical parameters and kid performance of goats. Anim. Biotechnol., 1\u20139.","DOI":"10.1080\/10495398.2021.1898978"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1590\/1806-9061-2016-0422","article-title":"Effects of phytogenic additives and organic acids, alone or in combination, on the performance, intestinal quality and immune responses of broiler chickens","volume":"19","author":"Fascina","year":"2017","journal-title":"Braz. J. Poult. Sci."},{"key":"ref_120","first-page":"177","article-title":"Essential oils as phytogenic feed additive: Potential benefits on environment, livestock health and production","volume":"4","author":"Dey","year":"2017","journal-title":"Int. J. Econ. Plants"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3923\/ajpsaj.2015.97.105","article-title":"Adding phytogenic material and\/or organic acids to broiler diets: Effect on performance, nutrient digestibility and net profit","volume":"9","author":"Hassan","year":"2015","journal-title":"Asian J. Poult. Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/15\/1973\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:03:46Z","timestamp":1760141026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/15\/1973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":121,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ani12151973"],"URL":"https:\/\/doi.org\/10.3390\/ani12151973","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]}}}