{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:34:33Z","timestamp":1791041673993,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The aim of this study is to report outcomes of dogs undergoing cholecystectomy for gall bladder mucocele (GBM) without flushing and catheterization of the common bile duct (CBD). This is a retrospective multicentric study from three veterinary referral hospitals and included 82 dogs diagnosed with GBM. Medical records were reviewed for clinical and histopathological findings. Long-term outcome was assessed with an owner questionnaire. The common bile duct was considered normal (&lt;4 mm), mildly dilated (5\u20136 mm) and moderately dilated (&gt;7 mm) in 88%, 10% and 2.4% of dogs, respectively. Surgery was uncomplicated in 83% of dogs. Intraoperative complications were recorded in 21% of dogs, with hypotension being the most common, whereas postoperative complications were documented in 20% of dogs, with vomiting\/regurgitation being the most common. Ninety-six percent of dogs that underwent cholecystectomy in this study survived to discharge. Follow-up ranged from 142 to 3930 days (median: 549 days). Eighty-five percent of dogs were alive at the time of follow-up. Dogs undergoing cholecystectomy for GBM without catheterization and flushing of the CBD have a favourable prognosis for recovery and quality of life.<\/jats:p>","DOI":"10.3390\/ani12162112","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T21:23:56Z","timestamp":1660771436000},"page":"2112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Outcome after Cholecystectomy without Common Bile Duct Catheterization and Flushing in Dogs"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-4088","authenticated-orcid":false,"given":"Matteo","family":"Rossanese","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services, Royal Veterinary College, London NW1 0TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-8807","authenticated-orcid":false,"given":"Phillipa","family":"Williams","sequence":"additional","affiliation":[{"name":"Dick White Referrals, Six Mile Bottom CB8 0UH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-7598","authenticated-orcid":false,"given":"Andrew","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Small Animal Teaching Hospital, University of Liverpool, Neston CH64 7TE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cinti","sequence":"additional","affiliation":[{"name":"Ospedale Veterinario I Portoni Rossi-Anicura, 40069 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2460\/javma.2004.224.1615","article-title":"Gallbladder mucocele in dogs: 30 cases (2000\u20132002)","volume":"224","author":"Pike","year":"2004","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2460\/javma.2004.225.1418","article-title":"Surgical management of gallbladder mucoceles in dogs: 22 cases (1999\u20132003)","volume":"225","author":"Worley","year":"2004","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.2460\/javma.229.9.1451","article-title":"Long-term survival and risk factors associated with biliary surgery in dogs: 34 cases (1994\u20132004)","volume":"229","author":"Amsellem","year":"2006","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kesimer, M., Cullen, J., Cao, R., Radicioni, G., Mathews, K.G., Seiler, G., and Gookin, J.L. (2015). Excess secretion of fel-forming mucin and associated innate defense proteins with defective mucin un-packaging underpin gallbladder mucocele formation in dogs. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138988"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105350","DOI":"10.1016\/j.tvjl.2019.105350","article-title":"Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele","volume":"251","author":"Jaffey","year":"2019","journal-title":"Vet. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1532-950X.2012.01072.x","article-title":"Clinical findings and prognostic factors for dogs undergoing cholecystectomy for gall bladder mucocele","volume":"42","author":"Malek","year":"2013","journal-title":"Vet. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1111\/jvim.15611","article-title":"Long-term survival of dogs treated for gallbladder mucocele by cholecystectomy, medical management, or both","volume":"33","author":"Parkanzky","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/jsap.13199","article-title":"Impact of intra-operative hypotension on mortality rates and post-operative complications in dogs undergoing cholecystectomy","volume":"61","author":"Hattersley","year":"2020","journal-title":"J. Small Anim. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/vsu.13542","article-title":"Association between biliary tree manipulation and outcome in dogs undergoing cholecystectomy for gallbladder mucocele: A multi-institutional retrospective study","volume":"50","author":"Piegols","year":"2020","journal-title":"Vet. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/vsu.13632","article-title":"Influence of normograde versus retrograde catheterization of bile ducts in dogs treated for gallbladder mucocele","volume":"50","author":"Putterman","year":"2021","journal-title":"Vet. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/jvim.15249","article-title":"Gall bladdermucoceles in Border terriers","volume":"32","author":"Allerton","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/jsap.12164","article-title":"Recent advances in soft tissue minimally invasive surgery","volume":"55","author":"Mayhew","year":"2014","journal-title":"J. Small Anim. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cvsm.2011.05.009","article-title":"Complications of the extrahepatic biliary surgery in companion animals","volume":"41","author":"Mehler","year":"2011","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.4102\/jsava.v86i1.1318","article-title":"Gallbladder mucocele: A review","volume":"86","author":"Smalle","year":"2015","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"970","DOI":"10.2460\/javma.252.8.970","article-title":"Outcome of elective cholecystectomy for the treatment of gallbladder disease in dogs","volume":"252","author":"Youn","year":"2018","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/jsap.12832","article-title":"CT cholangiography in dogs with gallbladder mucocoele","volume":"59","author":"Hayakawa","year":"2018","journal-title":"J. Small Anim. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1532-950X.2008.00428.x","article-title":"Laparoscopic cholecystectomy for management of uncomplicated gall bladder mucocele in six dogs","volume":"37","author":"Mayhew","year":"2008","journal-title":"Vet. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.suc.2018.11.005","article-title":"An update on technical aspect of cholecystectomy","volume":"99","author":"Sanford","year":"2018","journal-title":"Surg. Clin. N. Am."},{"key":"ref_19","first-page":"O156","article-title":"Laparoscopic Cholecystectomy with single port access system in 15 dogs","volume":"49","author":"Simon","year":"2019","journal-title":"Vet. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1292\/jvms.18-0266","article-title":"Short-term outcome of laparoscopic cholecystectomy for benign gall bladder diseases in 76 dogs","volume":"80","author":"Kanai","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"ref_21","first-page":"O150","article-title":"Intraoperative cholangiography and bile duct flushing in 47 dogs receiving laparoscopic cholecystectomy for benign gall bladder disease: A retrospective analysis","volume":"51","author":"Kanai","year":"2021","journal-title":"Vet. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"O49","DOI":"10.1111\/vsu.12534","article-title":"Perioperative complications and outcome of laparoscopic cholecystectomy in 20 dogs","volume":"45","author":"Scott","year":"2016","journal-title":"Vet. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1740-8261.2000.tb01489.x","article-title":"Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele","volume":"41","author":"Besso","year":"2000","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1532-950X.2004.04087.x","article-title":"Variables associated with outcome in dogs undergoing extrahepatic biliary sur-gery: 60 cases (1988\u20132002)","volume":"33","author":"Mehler","year":"2004","journal-title":"Vet. Surg."},{"key":"ref_25","first-page":"113","article-title":"Pathophysiological consequences of cholecystectomy","volume":"133","author":"Wakim","year":"1971","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jcu.10071","article-title":"Role of sonography in the diagnosis of gallbladder perforation","volume":"30","author":"Sood","year":"2002","journal-title":"J. Clin. Ultrasound"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4142\/jvs.2018.19.5.653","article-title":"Evaluation of gallbladder and common bile duct size and appearance by computed tomography in dogs","volume":"19","author":"Park","year":"2018","journal-title":"J. Vet. Sci."},{"key":"ref_28","first-page":"249","article-title":"Di una speciale disposizione a sfintere allo sbocco del coledoco","volume":"Volume 2","author":"Oddi","year":"1887","journal-title":"Annali Dell\u2019 Universita Libera di Perugia"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/16\/2112\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:11:24Z","timestamp":1760141484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/16\/2112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":28,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ani12162112"],"URL":"https:\/\/doi.org\/10.3390\/ani12162112","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]}}}