{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:57:47Z","timestamp":1793041067541,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Doctor Launch Project of Yibin University","award":["2019QD09"],"award-info":[{"award-number":["2019QD09"]}]},{"name":"Doctor Launch Project of Yibin University","award":["2019QD10"],"award-info":[{"award-number":["2019QD10"]}]},{"name":"Doctor Launch Project of Yibin University","award":["2020B1111320001"],"award-info":[{"award-number":["2020B1111320001"]}]},{"name":"Doctor Launch Project of Yibin University","award":["2020A1111280010"],"award-info":[{"award-number":["2020A1111280010"]}]},{"name":"Doctor Launch Project of Yibin University","award":["2021YFF0703300"],"award-info":[{"award-number":["2021YFF0703300"]}]},{"name":"Research and Development Projects in Key Areas of Guangdong Province","award":["2019QD09"],"award-info":[{"award-number":["2019QD09"]}]},{"name":"Research and Development Projects in Key Areas of Guangdong Province","award":["2019QD10"],"award-info":[{"award-number":["2019QD10"]}]},{"name":"Research and Development Projects in Key Areas of Guangdong Province","award":["2020B1111320001"],"award-info":[{"award-number":["2020B1111320001"]}]},{"name":"Research and Development Projects in Key Areas of Guangdong Province","award":["2020A1111280010"],"award-info":[{"award-number":["2020A1111280010"]}]},{"name":"Research and Development Projects in Key Areas of Guangdong Province","award":["2021YFF0703300"],"award-info":[{"award-number":["2021YFF0703300"]}]},{"name":"National Key R&amp;D Program of China","award":["2019QD09"],"award-info":[{"award-number":["2019QD09"]}]},{"name":"National Key R&amp;D Program of China","award":["2019QD10"],"award-info":[{"award-number":["2019QD10"]}]},{"name":"National Key R&amp;D Program of China","award":["2020B1111320001"],"award-info":[{"award-number":["2020B1111320001"]}]},{"name":"National Key R&amp;D Program of China","award":["2020A1111280010"],"award-info":[{"award-number":["2020A1111280010"]}]},{"name":"National Key R&amp;D Program of China","award":["2021YFF0703300"],"award-info":[{"award-number":["2021YFF0703300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Since 2010, a variant of porcine epidemic diarrhea virus (PEDV) has re-emerged in several provinces of China, resulting in severe economic losses for the pork industry. Here, we isolated and identified a variant PEDV strain, SC-YB73, in Guangdong Province, China. The pathological observations of jejunum showed atrophy of villi and edema in the lamina propria. The sequence analysis of the viral genome identified a six-nucleotide insertion in the E gene, which has not previously been detected in PEDV strains. Furthermore, 50 nucleotide sites were unique in SC-YB73 compared with 27 other PEDV strains. The phylogenetic analysis based on the complete genome showed that SC-YB73 was clustered in variant subgroup GII-a, which is widely prevalent in the Chinese pig population. The recombination analysis suggested that SC-YB73 originated from the recombination of GDS47, US PEDV prototype-like strains TW\/Yunlin550\/2018, and COL\/Cundinamarca\/2014. In the present study, we isolated and genetically characterized a variant PEDV strain, thus providing essential information for the control of PED outbreaks in China.<\/jats:p>","DOI":"10.3390\/ani12172189","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T21:28:12Z","timestamp":1661462892000},"page":"2189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Characterization and Phylogenetic Analysis of a Variant Recombinant Porcine Epidemic Diarrhea Virus Strain in China"],"prefix":"10.3390","volume":"12","author":[{"given":"Xiaoliang","family":"Hu","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiao","family":"Lian","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucan","family":"He","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhige","family":"Tian","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayan","family":"Fan","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Forestry and Food Engineering, Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Yibin Animal and Plant Inspection and Quarantine Engineering Technology Research Center, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Senkang Biotech Development Co., Ltd., Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cong","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510633, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01317606","article-title":"A new coronavirus-like particle associated with diarrhea in swine","volume":"58","author":"Pensaert","year":"1978","journal-title":"Arch. 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