{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:30:07Z","timestamp":1791916207877,"version":"4.3.4"},"reference-count":58,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Province \u201c135\u201d Breeding Tackle Project","award":["2016NYZ0052"],"award-info":[{"award-number":["2016NYZ0052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study examined the effects of multi-strain probiotics (BL) and Perilla frutescens seed extract (PSE), alone or in combination, on weaning piglets. In total, 96 weaning piglets were allocated into four treatments: CON group (the basal diet), PSE group (basal diet + 1g\/kg PSE), BL group (basal diet + 2 g\/kg BL), and BL+PSE group (basal diet +1 g\/kg PSE + 2 g\/kg BL) according to a 2 \u00d7 2 factorial arrangement. The supplementation of BL or PSE improved the gain to feed ratio. Dietary BL reduced diarrhea occurrence and Escherichia coli, but increased Lactobacillus counts in the ileal digesta. Dietary PSE tended to increase Lactobacillus counts in the ileal digesta. Interactive effects were found in terms of ileal villus height, the gene expression of IL-1\u03b2, and malondialdehyde in the ileal mucosa. Dietary BL lowered malondialdehyde in the spleen, liver, and jejunal mucosa but increased the total antioxidant capacity (T-AOC) in the liver and ileum mucosa. The supplementation of PSE improved superoxide dismutase in serum and T-AOC in the liver, and reduced MDA in liver, spleen, and jejunum mucosa. Taken together, BL or PSE showed positive effects, improving growth and intestinal morphology and enhancing antioxidant capacity. However, their interaction showed no beneficial effects on the antioxidant indices and the intestinal morphology of weaned piglets.<\/jats:p>","DOI":"10.3390\/ani12172246","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T21:25:18Z","timestamp":1661894718000},"page":"2246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Multi-Strain Probiotics and Perilla frutescens Seed Extract Supplementation Alone or Combined on Growth Performance, Antioxidant Indices, and Intestinal Health of Weaned Piglets"],"prefix":"10.3390","volume":"12","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4461","authenticated-orcid":false,"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal Resource and Science, Dankook University, Cheonan 31116, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-4199","authenticated-orcid":false,"given":"Yong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-194X","authenticated-orcid":false,"given":"Zhengfeng","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqiang","family":"Che","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-8542","authenticated-orcid":false,"given":"Shengyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, 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Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, 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