{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:00:06Z","timestamp":1773266406715,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mexican Council of Science and Technology","award":["CONACyT 167697"],"award-info":[{"award-number":["CONACyT 167697"]}]},{"name":"Mexican Council of Science and Technology","award":["G-12-MD007591"],"award-info":[{"award-number":["G-12-MD007591"]}]},{"name":"National Institutes of Health","award":["CONACyT 167697"],"award-info":[{"award-number":["CONACyT 167697"]}]},{"name":"National Institutes of Health","award":["G-12-MD007591"],"award-info":[{"award-number":["G-12-MD007591"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Prolactin (PRL) is a hormone expressed in lactotrophs cells of the pituitary gland in primates. Extra pituitary expression of PRL has been reported, including the eye; however, expression in the developing eye of primates is limited. The aim of the study was determining the expression of PRL and PRL receptor (PRLR) (mRNAs and proteins) in adult and fetal baboon (Papio hamadryas) ocular tissues. Methods: We analyzed PRL and PRLR in baboon eyes tissues by immunofluorescence. The mRNAs of PRL and PRLR were detected by RT-PCR, cDNA was cloned, and sequenced. Furthermore, we performed a phylogenetic analysis to identify the evolutionary forces that underlie the divergence of PRL and PRLR primate genes. Results: We observed the expression of PRL and PRLR (mRNAs and proteins) in all retinal cell lineages of fetal and adult baboon. PRL and PRLR fit the hypothesis of evolutionary purifying gene selection. Conclusions: mRNA and protein of PRL and PRLR are expressed in fetal and adult baboon retinal tissue. PRL may trigger autocrine and paracrine-specific actions in retinal cell lines.<\/jats:p>","DOI":"10.3390\/ani12172288","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T20:48:25Z","timestamp":1662410905000},"page":"2288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prolactin Expression in the Baboon (Papio hamadryas) Eye"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-2713","authenticated-orcid":false,"given":"Mar\u00eda Lourdes","family":"Garza-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-4168","authenticated-orcid":false,"given":"Iram Pablo","family":"Rodr\u00edguez-Sanchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Molecular y Estructural, Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza 66455, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-3210","authenticated-orcid":false,"given":"Rafael","family":"Gonz\u00e1lez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Guadalajara, Zapopan 45129, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-500X","authenticated-orcid":false,"given":"Maricela","family":"Luna","sequence":"additional","affiliation":[{"name":"Departamento de Neurobiolog\u00eda Celular y Molecular, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla 76230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-8354","authenticated-orcid":false,"given":"Carlos Horacio","family":"Burciaga-Flores","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Alcorta-Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-3818","authenticated-orcid":false,"given":"Orlando","family":"Solis-Coronado","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"},{"name":"Divisi\u00f3n de Anatom\u00eda Patol\u00f3gica, Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Secretar\u00eda de Salud, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-8738","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Bautista de Lucio","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Prote\u00f3mica Ocular, Instituto de Oftalmolog\u00eda \u201cFundaci\u00f3n de Asistencia Privada Conde de Valenciana\u201d, Ciudad de M\u00e9xico 06800, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genaro A.","family":"Ram\u00edrez-Correa","sequence":"additional","affiliation":[{"name":"Department of Molecular Science, University of Texas Health Rio Grande Valley, McAllen, TX 78550, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Vidal-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Cristina","family":"P\u00e9rez-Ibave","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey 64440, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000094309","article-title":"Vasoinhibins: A family of N-terminal prolactin fragments that inhibit angiogenesis and 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