{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:43:08Z","timestamp":1767706988098,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Locomotor training (LT) is task-specific repetitive training, with sensorimotor stimulation and intensive exercises that promote neuromuscular reorganization. This study aimed to observe if LT could be initiated safely in the first 3\u201315 days after surgery in tetraplegic C1\u2013C5 IVDD\u2014Hansen type I dogs. This prospective blinded clinical study was conducted at two rehabilitation centers in Portugal, with 114 grade 1 (MFS\/OFS) dogs, divided by the presence of spinal hyperesthesia into the SHG (spinal hyperesthesia group) (n = 74) and the NSHG (non-spinal hyperesthesia group) (n = 40), evaluated in each time point for two weeks according to a neurorehabilitation checklist by three observers for inter-agreement relation. LT was safely applied with 62.3% of the OFS \u2265 11 within 15 days and of these, 32.4% achieved a OFS \u2265 13. There were no new cases of hyperesthesia in the NSHG and from the SHG all recovered. Comparing groups, a significant difference was observed in their ability to achieve ambulatory status (p &lt; 0.001), between the presence of hyperesthesia and days until ambulation (p &lt; 0.006) and in each time point (p &lt; 0.001; R2 = 0.809). Early LT may be a safe treatment to be applied in the first 3 days on these dogs and spinal hyperesthesia should be important to the rehabilitation team. This study should be continued.<\/jats:p>","DOI":"10.3390\/ani12182369","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T20:52:25Z","timestamp":1663015945000},"page":"2369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early Locomotor Training in Tetraplegic Post-Surgical Dogs with Cervical Intervertebral Disc Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"D\u00e9bora","family":"Gouveia","sequence":"first","affiliation":[{"name":"Arr\u00e1bida Veterinary Hospital\u2014Arr\u00e1bida Animal Rehabilitation Center, 2925-538 Setubal, Portugal"},{"name":"Superior School of Health, Protection and Animal Welfare, Polytechnic Institute of Lusophony, Campo Grande, 1950-396 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Arr\u00e1bida Veterinary Hospital\u2014Arr\u00e1bida Animal Rehabilitation Center, 2925-538 Setubal, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Arr\u00e1bida Veterinary Hospital\u2014Arr\u00e1bida Animal Rehabilitation Center, 2925-538 Setubal, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3scar","family":"Gamboa","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisboa, Portugal"},{"name":"CIISA\u2014Centro Interdisciplinar-Investigac\u0327\u00e3o em Sa\u00fade Animal, Faculdade de Medicina Veterin\u00e1ria, Av. Universidade T\u00e9cnica de Lisboa, 1300-477 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-2582","authenticated-orcid":false,"given":"\u00c2ngela","family":"Martins","sequence":"additional","affiliation":[{"name":"Arr\u00e1bida Veterinary Hospital\u2014Arr\u00e1bida Animal Rehabilitation Center, 2925-538 Setubal, Portugal"},{"name":"Superior School of Health, Protection and Animal Welfare, Polytechnic Institute of Lusophony, Campo Grande, 1950-396 Lisboa, Portugal"},{"name":"CIISA\u2014Centro Interdisciplinar-Investigac\u0327\u00e3o em Sa\u00fade Animal, Faculdade de Medicina Veterin\u00e1ria, Av. Universidade T\u00e9cnica de Lisboa, 1300-477 Lisboa, Portugal"},{"name":"Faculty of Veterinary Medicine, Lus\u00f3fona University, Campo Grande 376, 1749-024 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,11]]},"reference":[{"key":"ref_1","first-page":"1477","article-title":"Cervical intervertebral disk disease in dogs","volume":"14","author":"Toombs","year":"1992","journal-title":"Compend. Contin. Educ. Pract. Vet."},{"key":"ref_2","unstructured":"Duncan, L.L. (2002). Surgery of the cervical spine. Small Animal Surgery, Mosby Publishing Co."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2460\/javma.2001.218.1598","article-title":"Ventilatory failure, ventilator management, and outcome in dogs with cervical spinal disorders: 14 cases (1991\u20131999)","volume":"218","author":"Beal","year":"2001","journal-title":"J. Am. Vet. Med. 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