{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:46:35Z","timestamp":1761975995463,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The gold-standard treatment for functional tumors is adrenalectomy, and the procedure can be either open or laparoscopic. Laparoscopic adrenalectomy (LA) is a minimally invasive technique designated for small\u2013medium-sized adrenal tumors without vascular invasion. LA is routinely performed using three or four ports with the patient in sternal or lateral recumbency. The aim of the study was to evaluate the feasibility of LA with two ports in order to reduce invasiveness and improve patient recovery. In total, 16 dogs with adrenal tumors were included in the study and the two-port technique was performed. Adrenalectomy was performed based on the presence of hypercortisolism in thirteen cases, whereas, in three cases, adrenalectomy was performed in the absence of evidence of cortisol production. Thirteen cases were carcinomas and three were adenomas of the adrenal gland; furthermore, twelve were on the left side and four were on the right side. Capsule rupture occurred in five cases. After performing the technique in all cases, no additional ports or laparotomy conversion occurred. Based on the authors\u2019 experience, laparoscopic adrenalectomy can be performed with two ports.<\/jats:p>","DOI":"10.3390\/ani12212917","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:29:45Z","timestamp":1666700985000},"page":"2917","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Two-Port Laparoscopic Adrenalectomy in Dogs"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2158-9032","authenticated-orcid":false,"given":"Francesco","family":"Collivignarelli","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-4321","authenticated-orcid":false,"given":"Amanda","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-5102","authenticated-orcid":false,"given":"Andrea","family":"Paolini","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-4051","authenticated-orcid":false,"given":"Massimo","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-0059","authenticated-orcid":false,"given":"Paolo Emidio","family":"Crisi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9076-8176","authenticated-orcid":false,"given":"Ilaria","family":"Falerno","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea De","family":"Bonis","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Rosto","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-163X","authenticated-orcid":false,"given":"Roberto","family":"Tamburro","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Lunn, K.F., and Boston, S.E. (2020). Tumors of the Endocrine System. Withrow and MacEwen\u2019s Small Animal Clinical Oncology, Elsevier.","key":"ref_1","DOI":"10.1016\/B978-0-323-59496-7.00026-8"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.cvsm.2009.05.004","article-title":"Advanced Laparoscopic Procedures (Hepatobiliary, Endocrine) in Dogs and Cats","volume":"39","author":"Mayhew","year":"2009","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"O99","DOI":"10.1111\/vsu.13565","article-title":"A Comparison of Outcomes between Laparoscopic and Open Adrenalectomies in Dogs","volume":"50","author":"Taylor","year":"2021","journal-title":"Vet. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2460\/javma.244.10.1181","article-title":"Clinical Findings in Dogs with Incidental Adrenal Gland Lesions Determined by Ultrasonography: 151 Cases (2007\u20132010)","volume":"244","author":"Cook","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/jvim.12192","article-title":"Diagnosis of Spontaneous Canine Hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal)","volume":"27","author":"Behrend","year":"2013","journal-title":"J. Vet. Intern. Med."},{"doi-asserted-by":"crossref","unstructured":"Balsa, I., and Culp, W. (2019). Use of Minimally Invasive Surgery in the Diagnosis and Treatment of Cancer in Dogs and Cats. Vet. Sci., 6.","key":"ref_6","DOI":"10.3390\/vetsci6010033"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/vsu.13221","article-title":"Perioperative Morbidity and Mortality in Dogs with Invasive Adrenal Neoplasms Treated by Adrenalectomy and Cavotomy","volume":"48","author":"Mayhew","year":"2019","journal-title":"Vet. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2460\/javma.2003.223.654","article-title":"Surgical Management of Adrenal Gland Tumors with and without Associated Tumor Thrombi in Dogs: 40 Cases (1994\u20132001)","volume":"223","author":"Kyles","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2460\/javma.245.9.1028","article-title":"Comparison of Perioperative Morbidity and Mortality Rates in Dogs with Noninvasive Adrenocortical Masses Undergoing Laparoscopic versus Open Adrenalectomy","volume":"245","author":"Mayhew","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1532-950X.2008.00410.x","article-title":"Laparoscopic Adrenalectomy for Treatment of Unilateral Adrenocortical Carcinomas: Technique, Complications, and Results in Seven Dogs","volume":"37","author":"Bouvy","year":"2008","journal-title":"Vet. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1532-950X.2013.12029.x","article-title":"Innovative Approach to Laparoscopic Adrenalectomy for Treatment of Unilateral Adrenal Gland Tumors in Dogs","volume":"42","author":"Naan","year":"2013","journal-title":"Vet. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"O75","DOI":"10.1111\/vsu.12789","article-title":"Feasibility of Single-Port Retroperitoneoscopic Adrenalectomy in Dogs","volume":"47","author":"Ko","year":"2018","journal-title":"Vet. Surg."},{"doi-asserted-by":"crossref","unstructured":"Fransson, B.A., and Mayhew, P.D. (2022). Laparoscopic Adrenalectomy. Small Animal Laparoscopy and Thoracoscopy, Wiley.","key":"ref_13","DOI":"10.1002\/9781119666912"},{"doi-asserted-by":"crossref","unstructured":"Sasaki, A., Nitta, H., Otsuka, K., Nishizuka, S., Baba, S., Umemura, A., Koeda, K., Mizuno, M., and Wakabayashi, G. (2013). Laparoendoscopic Single Site Adrenalectomy: Initial Results of Cosmetic Satisfaction and the Potential for Postoperative Pain Reduction. BMC Urol., 13.","key":"ref_14","DOI":"10.1186\/1471-2490-13-21"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105391","DOI":"10.1016\/j.tvjl.2019.105391","article-title":"Short-Term Surgical Outcomes and Histomorphological Evaluation of Thermal Injury Following Palatoplasty Performed with Diode Laser or Air Plasma Device in Dogs with Brachycephalic Airway Obstructive Syndrome","volume":"253","author":"Tamburro","year":"2019","journal-title":"Vet. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1354\/vp.41-5-490","article-title":"Indicators of Malignancy of Canine Adrenocortical Tumors: Histopathology and Proliferation Index","volume":"41","author":"Labelle","year":"2004","journal-title":"Vet. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2460\/javma.239.2.203","article-title":"Surgical Time and Severity of Postoperative Pain in Dogs Undergoing Laparoscopic Ovariectomy with One, Two, or Three Instrument Cannulas","volume":"239","author":"Case","year":"2011","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1532-950X.2009.00572.x","article-title":"The Effect of Laparoscopic versus Open Ovariectomy on Postsurgical Activity in Small Dogs","volume":"38","author":"Culp","year":"2009","journal-title":"Vet. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2460\/javma.2005.227.921","article-title":"Duration, Complications, Stress, and Pain of Open Ovariohysterectomy versus a Simple Method of Laparoscopic-Assisted Ovariohysterectomy in Dogs","volume":"227","author":"Devitt","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.cvsm.2011.05.008","article-title":"Complications of Minimally Invasive Surgery in Companion Animals","volume":"41","author":"Mayhew","year":"2011","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2460\/javma.242.12.1715","article-title":"Evaluation of Risk Factors for Outcome Associated with Adrenal Gland Tumors with or without Invasion of the Caudal Vena Cava and Treated via Adrenalectomy in Dogs: 86 Cases (1993\u20132009)","volume":"242","author":"Barrera","year":"2013","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/vsu.12462","article-title":"Preoperative Differential Diagnosis of Canine Adrenal Tumors Using Triple-Phase Helical Computed Tomography: Preoperative CT of Canine Adrenal Tumors","volume":"45","author":"Yoshida","year":"2016","journal-title":"Vet. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/0300985818819174","article-title":"Pheochromocytoma in Dogs Undergoing Adrenalectomy","volume":"56","author":"Zini","year":"2019","journal-title":"Vet. Pathol."},{"doi-asserted-by":"crossref","unstructured":"Bianchi, A., Collivignarelli, F., Vignoli, M., Scaletta, L., Cuomo, A., Falerno, I., Paolini, A., and Tamburro, R. (2021). A Comparison of Times Taken for the Placement of the First Portal and Complication Rates between the Veress Needle Technique and the Modified Hasson Technique in Canine Ovariectomy Laparoscopic Surgery. Animals, 11.","key":"ref_24","DOI":"10.3390\/ani11102936"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5326\/15473317-37-1-93","article-title":"Surgical Treatment of Adrenocortical Tumors: 21 Cases (1990\u20131996)","volume":"37","author":"Anderson","year":"2001","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2460\/javma.232.1.77","article-title":"Evaluation of Prognostic Factors in the Surgical Treatment of Adrenal Gland Tumors in Dogs: 41 Cases (1999\u20132005)","volume":"232","author":"Schwartz","year":"2008","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/01652176.1995.9694547","article-title":"Results of Adrenalectomy in 36 Dogs with Hyperadrenocorticism Caused by Adrenocortical Tumour","volume":"17","author":"Sjollema","year":"1995","journal-title":"Vet. Q."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2460\/javma.239.2.216","article-title":"Adrenalectomy in Dogs with Adrenal Gland Tumors: 52 Cases (2002\u20132008)","volume":"239","author":"Massari","year":"2011","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/vco.12587","article-title":"Outcome in Dogs Undergoing Adrenalectomy for Small Adrenal Gland Tumours without Vascular Invasion","volume":"18","author":"Cavalcanti","year":"2020","journal-title":"Vet. Comp. Oncol."},{"doi-asserted-by":"crossref","unstructured":"Lacitignola, L., Trisciuzzi, R., Imperante, A., Fracassi, L., Crovace, A.M., and Staffieri, F. (2020). Comparison of Laparoscopic Steerable Instruments Performed by Expert Surgeons and Novices. Vet. Sci., 7.","key":"ref_30","DOI":"10.3390\/vetsci7030135"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/vsu.12373","article-title":"Comparison of Single Port Access Versus Multiple Port Access Systems in Elective Laparoscopy: 98 Dogs (2005\u20132014)","volume":"44","author":"Monnet","year":"2015","journal-title":"Vet. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"916","DOI":"10.2460\/javma.248.8.916","article-title":"Laparoscopic-Assisted Splenectomy in Dogs: 18 Cases (2012\u20132014)","volume":"248","author":"Wright","year":"2016","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2460\/javma.245.11.1258","article-title":"Single-Port Laparoscopic Cryptorchidectomy in Dogs and Cats: 25 Cases (2009\u20132014)","volume":"245","author":"Runge","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"doi-asserted-by":"crossref","unstructured":"Lacitignola, L., Guadalupi, M., and Massari, F. (2021). Single Incision Laparoscopic Surgery (SILS) in Small Animals: A Systematic Review and Meta-Analysis of Current Veterinary Literature. Vet. Sci., 8.","key":"ref_34","DOI":"10.3390\/vetsci8080144"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1007\/s00268-010-0494-4","article-title":"Single-Access Retroperitoneoscopic Adrenalectomy (SARA) Versus Conventional Retroperitoneoscopic Adrenalectomy (CORA): A Case\u2013Control Study","volume":"34","author":"Walz","year":"2010","journal-title":"World J. Surg."},{"key":"ref_36","first-page":"45","article-title":"Single Access Retroperitoneoscopic Adrenalectomy: Initial Experience","volume":"7","author":"Strupas","year":"2012","journal-title":"Wideochir. Inne Tech. Maloinwazyjne"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"O102","DOI":"10.1111\/vsu.12571","article-title":"Retroperitoneal Laparoscopy in Dogs: Access Technique, Working Space, and Surgical Anatomy","volume":"45","author":"Jeong","year":"2016","journal-title":"Vet. Surg."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/21\/2917\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:05Z","timestamp":1760144525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/12\/21\/2917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":37,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ani12212917"],"URL":"https:\/\/doi.org\/10.3390\/ani12212917","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2022,10,25]]}}}