{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:44Z","timestamp":1787027564197,"version":"build-2736575974"},"reference-count":31,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: Extramedullary plasmacytoma (EMP) is a plasma cell tumor that is very rarely reported in ocular and adnexal tissue and is usually solitary and benign. Methods: This study evaluated seven cases from different ophthalmology referrals submitted for histopathological analysis between 2013 and 2022. Results: EMPs were diagnosed in a 9-year-old domestic short-haired cat and in six dogs (median age, 10 years): three English Cocker Spaniels, a Golden Retriever, a Maltese, and a Pinscher. EMPs affected the third eyelid conjunctiva in five cases (5\/7), followed by the superior bulbar (1\/7) and palpebral conjunctivae (1\/7), respectively, and were presented mostly as well-defined, salmon-colored nodules. Histopathologically, the masses were composed of sheets and packets of round cells morphologically consistent with mature plasma cells with mild anisocytosis and anisokaryosis; mitosis and binucleated giant cells were rarely observed. Follow up for 6\/7 cases ranged from 6 months to 2 years. No signs of recurrence or systemic involvement (multiple myeloma) were observed. Conclusions: EMP should be included in the differential diagnoses of canine and feline conjunctival masses. Staging recommendations should include multiple myeloma diagnostic evaluation. Our results suggest that primary conjunctival EMP does not appear to be locally aggressive and has low systemic involvement behavior. The local surgical excision alone or combined with cryotherapy should be curative.<\/jats:p>","DOI":"10.3390\/ani12213015","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T04:49:20Z","timestamp":1667450960000},"page":"3015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Conjunctival Extramedullary Plasmacytoma in Dogs and a Cat: Clinical Characteristics and Histopathological Findings"],"prefix":"10.3390","volume":"12","author":[{"given":"Aleksandra","family":"Rawicka","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Roma Sud, Via Pilade Mazza 24, 00173 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Crasta","sequence":"additional","affiliation":[{"name":"Anicura VisionVet Eye Clinic, Via Antonio Marzocchi 6, San Giovanni in Persiceto, 40017 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Guandalini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centro Veterinario Specialistico, Via Sandro Giovannini 53, 00137 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-9934","authenticated-orcid":false,"given":"Claudio","family":"Peruccio","sequence":"additional","affiliation":[{"name":"Veterinary Ophthalmology Referrals Centro Veterinario Torinese, Lungo Dora Colletta 147, 10153 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Multari","sequence":"additional","affiliation":[{"name":"Centro Veterinario Oculistico Fontane, Via Donatori del Sangue 1, 31020 Villorba, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rondena","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Privata San Marco Srl, Via dell\u2019Industria, 3, 35030 Veggiano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"D\u2019Anna","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Roma Sud, Via Pilade Mazza 24, 00173 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-4085","authenticated-orcid":false,"given":"Chiara","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, Universit\u00e0 degli Studi di Milano, 26009 Lodi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9975(08)80246-0","article-title":"Immunoglobulin-producing tumors in dogs and cats","volume":"109","author":"Breuer","year":"1993","journal-title":"J. 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