{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:22:35Z","timestamp":1790281355158,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007801","name":"Seneca foundation of Murcia Regional Government, Spain","doi-asserted-by":"publisher","award":["19894\/GERM\/15"],"award-info":[{"award-number":["19894\/GERM\/15"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Seneca foundation of Murcia Regional Government, Spain","doi-asserted-by":"publisher","award":["FJC2019-042475-I"],"award-info":[{"award-number":["FJC2019-042475-I"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["19894\/GERM\/15"],"award-info":[{"award-number":["19894\/GERM\/15"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["FJC2019-042475-I"],"award-info":[{"award-number":["FJC2019-042475-I"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In this report, the measurement of salivary biomarkers as an aid for diagnosis of equine gastric ulcer syndrome (EGUS) was studied. A comprehensive panel of 23 salivary analytes was measured in the saliva of horses affected by EGUS and compared to healthy animals and horses with other diseases clinically similar to EGUS but with a negative diagnosis at gastroscopic examination. A total of 147 horses were included in the study and divided into heathy population (n = 12), the EGUS group (n = 110), and the group of horses with other diseases (n = 25). From the 23 analytes studied, 17 showed increased values in EGUS horses when compared to healthy ones, and uric acid, triglycerides, and calcium were significantly increased in horses with EGUS compared to the group of other diseases. The receiver operating characteristic curve analyses showed a modest but significant discriminatory power of those three analytes to identify EGUS from other diseases with similar symptoms. The discriminatory power enhanced when the results of the three analytes were combined. In conclusion, the results showed that selected salivary analytes could have potential use as biomarkers in horses with EGUS.<\/jats:p>","DOI":"10.3390\/ani12233261","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:25:36Z","timestamp":1669256736000},"page":"3261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of a Comprehensive Profile of Salivary Analytes for the Diagnosis of the Equine Gastric Ulcer Syndrome"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-8712","authenticated-orcid":false,"given":"Alberto","family":"Mu\u00f1oz-Prieto","sequence":"first","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"},{"name":"Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J.","family":"Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-4147","authenticated-orcid":false,"given":"Camila P.","family":"Rubio","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2898-0410","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Contreras-Aguilar","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-1162","authenticated-orcid":false,"given":"Luis","family":"Pardo-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ayala-de la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Animal Medicine and Surgery Department, Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mart\u00edn-Cuervo","sequence":"additional","affiliation":[{"name":"Animal Medicine, Faculty of Veterinary Medicine of C\u00e1ceres, University of Extremadura, Av. de la Universidad S-N, 10005 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida-Marie","family":"Holm Henriksen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary School of Medicine, Sektion Medicine and Surgery, University of Copenhagen, Hoejbakkegaard All\u00e9 5, DK-2630 H\u00f8je-Taastrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-1060","authenticated-orcid":false,"given":"Juli\u00e1n J.","family":"Arense-Gonzalo","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Murcia, IMIB-Arrixaca, El Palmar, 30120 Murcia, Spain"},{"name":"Division of Preventive Medicine and Public Health Sciences, School of Medicine, University of Murcia, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tecles","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis of the University of Murcia (Interlab-UMU), Regional Campus of International Excellence \u2018Campus Mare Nostrum\u2019, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanni","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary School of Medicine, Sektion Medicine and Surgery, University of Copenhagen, Hoejbakkegaard All\u00e9 5, DK-2630 H\u00f8je-Taastrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/BF03547028","article-title":"Post-Mortem Findings of Gastric Ulcers in Swedish Horses up to One Year of Age: A Retrospective Study 1924\u20131996","volume":"40","author":"Sandin","year":"1999","journal-title":"Acta Vet. 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