{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:57:14Z","timestamp":1789822634250,"version":"4.0.1"},"reference-count":51,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 109-2321-B-197-006"],"award-info":[{"award-number":["MOST 109-2321-B-197-006"]}]},{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 111-2628-B-197-001-MY3"],"award-info":[{"award-number":["MOST 111-2628-B-197-001-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["MOST 109-2321-B-197-006"],"award-info":[{"award-number":["MOST 109-2321-B-197-006"]}]},{"name":"National Science and Technology Council, Taiwan","award":["MOST 111-2628-B-197-001-MY3"],"award-info":[{"award-number":["MOST 111-2628-B-197-001-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) is a non-infectious disease characterized by chronic inflammation of the gastrointestinal tract. Currently, management of IBD is still a clinical challenge. The purpose of this study was to investigate the therapeutic potential of surfactin containing Bacillus licheniformis-fermented products (SBLF) and commercial surfactin (CS) on the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. We found that mice that received drinking water containing 3% DSS developed significant colitis symptoms, including increased disease activity index, body weight loss, shortening of the colon length, splenomegaly, colonic inflammation and colonic NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. Notably, orally received SBLF, CS or clinical anti-inflammatory drug 5-aminosalicylic acid improved DSS-induced colitis symptoms in mice. These findings show that SBLF can improve IBD in mice by reducing colonic inflammation and inhibiting the NLRP3 inflammasome activation, suggesting that SBLF has the potential to be used as a nutraceutical in humans or a feed additive in economic and companion animals for preventing IBD.<\/jats:p>","DOI":"10.3390\/ani12243456","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T02:17:57Z","timestamp":1670465877000},"page":"3456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Wei-Che","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ting","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Ta","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231405, Taiwan"},{"name":"School of Medicine, Buddhist Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-6006","authenticated-orcid":false,"given":"Yeong-Hsiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-8478","authenticated-orcid":false,"given":"Yu-Hsiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-1019","authenticated-orcid":false,"given":"Wei-Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Lung","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Wood Cellulose, Taiwan Forestry Research Institute, Taipei 100051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Feng","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Animal Science, National Ilan University, Yilan 260007, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. 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