{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:34:02Z","timestamp":1789594442626,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32060819"],"award-info":[{"award-number":["32060819"]}]},{"name":"National Natural Science Foundation of China","award":["2018YFD0501302"],"award-info":[{"award-number":["2018YFD0501302"]}]},{"name":"National Natural Science Foundation of China","award":["YC2020-S239"],"award-info":[{"award-number":["YC2020-S239"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["32060819"],"award-info":[{"award-number":["32060819"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2018YFD0501302"],"award-info":[{"award-number":["2018YFD0501302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["YC2020-S239"],"award-info":[{"award-number":["YC2020-S239"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Province Postgraduate Innovation Special Fund Project","award":["32060819"],"award-info":[{"award-number":["32060819"]}]},{"name":"Jiangxi Province Postgraduate Innovation Special Fund Project","award":["2018YFD0501302"],"award-info":[{"award-number":["2018YFD0501302"]}]},{"name":"Jiangxi Province Postgraduate Innovation Special Fund Project","award":["YC2020-S239"],"award-info":[{"award-number":["YC2020-S239"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Avian pathogenic E. coli (APEC) is typically the cause of avian colibacillosis, which can result in oxidative stress, inflammation, and intestinal damage (APEC). Luteolin, in the form of glycosylation flavone, has potent anti-inflammatory and anti-oxidative properties. However, its effects on APEC-induced intestinal oxidative stress and NF-\u03baB-mediated inflammation in chicks remains poorly understood. After hatching, one-day-old chicks were stochastically assigned to four groups: a control group (basic diet), an E. coli group (basic diet) and L10 and L20 groups (with a dry matter of luteolin diet 10 mg\/kg and 20 mg\/kg, respectively), with fifteen chicks in each group and one repeat per group. They were pretreated for thirteen days. The body weight, mortality, histopathological changes in the ileum, antioxidant status, and the mRNA and protein-expression levels of factors associated with the HMGB1\/TLR4\/NF-\u03baB signal axis of the chicks were measured. The results showed that luteolin treatment decreased the mRNA and protein-expression level of the related factors of HMGB1\/TLR4\/NF-\u03baB signal axis in the ileum, reduced inflammation, increased antioxidant enzyme activity, and reduced intestinal injury. Collectively, luteolin alleviated APEC-induced intestinal damage by means of hindering the HMGB1\/TLR4\/NF-\u03baB signal axis, which suggests that luteolin could be a good method for the prevention and treatment of avian colibacillosis.<\/jats:p>","DOI":"10.3390\/ani13010083","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:31:56Z","timestamp":1672126316000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Luteolin Attenuates APEC-Induced Oxidative Stress and Inflammation via Inhibiting the HMGB1\/TLR4\/NF-\u03baB Signal Axis in the Ileum of Chicks"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhanyou","family":"Cao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrong","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiming","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-8765","authenticated-orcid":false,"given":"Xiaoquan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1248\/bpb.34.379","article-title":"Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken","volume":"34","author":"He","year":"2011","journal-title":"Biol. 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