{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:54:48Z","timestamp":1780444488732,"version":"3.54.1"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Hebei Province, China","award":["C2021402019"],"award-info":[{"award-number":["C2021402019"]}]},{"name":"Natural Science Foundation of Hebei Province, China","award":["C2022402038"],"award-info":[{"award-number":["C2022402038"]}]},{"name":"Natural Science Foundation of Hebei Province, China","award":["22326602D"],"award-info":[{"award-number":["22326602D"]}]},{"name":"Hebei Science and Technology Agency, China","award":["C2021402019"],"award-info":[{"award-number":["C2021402019"]}]},{"name":"Hebei Science and Technology Agency, China","award":["C2022402038"],"award-info":[{"award-number":["C2022402038"]}]},{"name":"Hebei Science and Technology Agency, China","award":["22326602D"],"award-info":[{"award-number":["22326602D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>During normal pregnancy, there is a dynamic regulation of the maternal immune system, including the liver, to accommodate the presence of the allogeneic foetus in the uterus. However, it was unclear that the expression of the IkappaB (I\u03baB) family was regulated in the ovine maternal liver during early pregnancy. In this study, sheep livers were collected at day 16 of the oestrous cycle (NP16), and days 13, 16 and 25 of gestation (DP13, DP16 and DP25), and RT-qPCR, Western blot and immunohistochemistry analysis were used to analyse the expression of the I\u03baB family, including B cell leukemia-3 (BCL-3), I\u03baB\u03b1, I\u03baB\u03b2, I\u03baB\u03b5, IKK\u03b3, I\u03baBNS and I\u03baB\u03b6. The results revealed that expression of BCL-3, I\u03baB\u03b2, I\u03baB\u03b5 and IKK\u03b3 peaked at DP16, and the expression of I\u03baB\u03b1 was increased during early pregnancy. In addition, the expression of I\u03baB\u03b6 peaked at DP13 and DP16, and I\u03baBNS peaked at DP13. I\u03baB\u03b2 and IKK\u03b3 proteins were located in the endothelial cells of the proper hepatic arteries and portal veins, and hepatocytes. In conclusion, early pregnancy changed the expression of the I\u03baB family, suggesting that the modulation of the I\u03baB family may be related to the regulation of maternal hepatic functions, which may be favourable for pregnancy establishment in sheep.<\/jats:p>","DOI":"10.3390\/ani13061057","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:39:45Z","timestamp":1678855185000},"page":"1057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of IkappaB Family in the Ovine Liver during Early Pregnancy"],"prefix":"10.3390","volume":"13","author":[{"given":"Chunjiang","family":"Cai","sequence":"first","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-7102","authenticated-orcid":false,"given":"Shengya","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-0024","authenticated-orcid":false,"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"575197","DOI":"10.3389\/fimmu.2020.575197","article-title":"Maternal immunological adaptation during normal pregnancy","volume":"11","author":"Michalski","year":"2020","journal-title":"Front. 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