{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:34:01Z","timestamp":1789594441109,"version":"build-2803163510"},"reference-count":69,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272889"],"award-info":[{"award-number":["32272889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SQ2022YFD1300007"],"award-info":[{"award-number":["SQ2022YFD1300007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["32272889"],"award-info":[{"award-number":["32272889"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["SQ2022YFD1300007"],"award-info":[{"award-number":["SQ2022YFD1300007"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The aim of the study was to investigate the comparative effects of different combinations of sodium butyrate (SB), medium-chain fatty acids (MCFAs), and omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the reproductive performances of sows, as well as on the biochemical parameters, oxidative statuses, and intestinal health of the sucking piglets. A total of 30 sows were randomly allocated to five treatments: (1) control diet (CON); (2) CON with 1 g\/kg of coated SB and 7.75 g\/kg of coated MCFAs (SM); (3) CON with 1 g\/kg of coated SB and 68.2 g\/kg of coated n-3 PUFAs (SP); (4) CON with 7.75 g\/kg of coated MCFAs and 68.2 g\/kg of coated n-3 PUFAs (MP); (5) CON with 1 g\/kg of coated SB, 7.75 g\/kg of coated MCFAs and 68.2 g\/kg of coated n-3 PUFA (SMP). The results showed that sows fed the SP, MP, and SMP diets had shorter weaning-to-estrus intervals than those fed the CON diet (p &lt; 0.01). The piglets in the SM, SP, and MP groups showed higher increases in the plasma catalase and glutathione peroxidase activities than those of the CON group (p &lt; 0.01). The diarrhea incidence of piglets in the SM, SP and SMP groups was lower than that of piglets in the CON group (p &lt; 0.01). Additionally, the addition of SM, SP, MP, and SMP to the sow diets increased the contents of immunoglobulin A, immunoglobulin G, fat, and proteins in the colostrum (p &lt; 0.01), as well as the plasma total superoxide dismutase activities (p &lt; 0.01) in the suckling piglets, whereas it decreased the mRNA expressions of tumor necrosis factor-\u03b1, interleukin-1\u03b2, and toll-like receptor 4 in the jejunum mucosa of the piglets. The relative abundances of Prevotella, Coprococcus, and Blautia in the colonic digesta of the piglets were increased in the SM group (p &lt; 0.05), and the relative abundances of Faecalibacterium increased in the SMP group (p &lt; 0.05), compared with the CON group. The relative abundances of Collinsella, Blautia, and Bulleidia in the MP group were higher than those in the CON group (p &lt; 0.05). Collectively, dietary combinations of fatty acids with different chain lengths have positive effects on the growth performances and intestinal health of suckling piglets.<\/jats:p>","DOI":"10.3390\/ani13061093","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T02:38:27Z","timestamp":1679279907000},"page":"1093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Different Combinations of Sodium Butyrate, Medium-Chain Fatty Acids and Omega-3 Polyunsaturated Fatty Acids on the Reproductive Performance of Sows and Biochemical Parameters, Oxidative Status and Intestinal Health of Their Offspring"],"prefix":"10.3390","volume":"13","author":[{"given":"Caiyun","family":"You","sequence":"first","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaman","family":"Pang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiru","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-3367","authenticated-orcid":false,"given":"Weizhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"skac167","DOI":"10.1093\/jas\/skac167","article-title":"Evaluation of essential fatty acids in lactating sow diets on sow reproductive performance, colostrum and milk composition, and piglet survivability","volume":"100","author":"Holen","year":"2022","journal-title":"J. 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