{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:11:33Z","timestamp":1791947493305,"version":"4.3.4"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/19474-6"],"award-info":[{"award-number":["2018\/19474-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/07151-0"],"award-info":[{"award-number":["2019\/07151-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Antimicrobial growth promoters (AGPs) in animal production have been related to the increase in multidrug-resistant bacteria. The AGP ban in many countries has highlighted the growing need for alternatives for feed additives. Considering the non-antibiotic anti-inflammatory theory of AGPs, chicks received three different doses of sodium salicylate (SS) in feed (10, 30, 90 mg\/kg), basal diet (BD) was used as a negative control, and zinc bacitracin (ZB) was used as a positive control. Chicks were individually housed to increase the accuracy of the dose of SS ingested. Performance parameters and footpad dermatitis were evaluated weekly, while haematology, serum biochemistry, histopathology, and tibial dyschondroplasia were determined on Days 21 and 42. A linear dose-dependent decrease in haemoglobin concentration was observed, but the values were within the normal reference range. Among all the other evaluated parameters, no relevant differences between treatments were observed; however, not even the AGP group performed better than the control group. It is possible that the conditions in which the birds were raised were not stressful enough to allow for anti-inflammatories to demonstrate their beneficial effects on performance. Studies should be conducted where the animals are exposed to commercial conditions, as the presence of natural stressors could allow a better evaluation of the efficacy of the anti-inflammatory agent as a growth promoter.<\/jats:p>","DOI":"10.3390\/ani13091430","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T01:35:44Z","timestamp":1682300144000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sodium Salicylate as Feed Additive in Broilers: Absence of Toxicopathological Findings"],"prefix":"10.3390","volume":"13","author":[{"given":"Mayra Carraro","family":"Di Gregorio","sequence":"first","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-8552","authenticated-orcid":false,"given":"Elaine Renata Motta","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Momo","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8700","authenticated-orcid":false,"given":"Cristiane Soares","family":"da Silva Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-2856","authenticated-orcid":false,"given":"Isis Machado","family":"Hueza","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"},{"name":"Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Diadema 09913-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-3088","authenticated-orcid":false,"given":"Newton","family":"Andr\u00e9o-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Diadema 09913-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonila Ester Reinert","family":"Raspantini","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-0522","authenticated-orcid":false,"given":"Andr\u00e9 Tadeu","family":"Gotardo","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Lima","family":"G\u00f3rniak","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"ref_1","unstructured":"United States Department of Agriculture (Foreign Agricultural Service) (2023, March 01). 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