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We randomly assigned 360 one-day-old AA white-feathered chicks in three treatments: basal diet (control), basal diet plus zinc bacitracin (antibiotic), and basal diet plus L. reuteri SL001 (SL001) treatment. The results showed the total BW gain and average daily gain (ADG) of broilers in SL001 treatment increased significantly (p &lt; 0.05, respectively) compared with the control group from day 0 to 42. Moreover, we observed higher levels of immune globulins in both the SL001 group and the antibiotic group. Total antioxidant capacity and levels of antioxidant factors were also significantly increased (p \u2264 0.05, respectively) in the SL001 treatment group, while the interleukin 6, interleukin 4, creatinine, uric acid, total cholesterol, triglyceride, VLDL, LDL and malondialdehyde were remarkably decreased (p &lt; 0.05, respectively). In the ileum of SL001 treatment broilers, the height of villi and the ratio of villi height to crypt depth were significantly increased (p &lt; 0.05). Meanwhile, the crypt depth reduced (p &lt; 0.01) and the ratio of villi height to crypt depth increased (p &lt; 0.05) in the jejunum compared to the control. The abundance of microbiota increased in the gut of broilers supplemented with SL001. Dietary SL001 significantly increased the relative abundance of Actinobacteria in the cecal contents of broilers (p &lt; 0.01) at the phylum level. In conclusion, L. reuteri SL001 supplementation promotes the growth performance of broiler chickens and exhibits the potential application value in the industry of broiler feeding.<\/jats:p>","DOI":"10.3390\/ani13101690","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T09:23:10Z","timestamp":1684488190000},"page":"1690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Dietary Lactobacillus reuteri SL001 Improves Growth Performance, Health-Related Parameters, Intestinal Morphology and Microbiota of Broiler Chickens"],"prefix":"10.3390","volume":"13","author":[{"given":"Chunli","family":"Chai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Mohamed","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-5914","authenticated-orcid":false,"given":"Gifty Z.","family":"Bumbie","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamao","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiru","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3382\/ps\/pey539","article-title":"The application of antibiotics in broiler production and the resulting antibiotic resistance in Escherichia coli: A global overview","volume":"98","author":"Roth","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.diagmicrobio.2006.03.014","article-title":"Flavophospholipol use in animals: Positive implications for antimicrobial resistance based on its microbiologic properties","volume":"56","author":"Pfaller","year":"2006","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aninu.2018.03.002","article-title":"Use of antibiotics in broiler production: Global impacts and alternatives","volume":"4","author":"Mehdi","year":"2018","journal-title":"Anim. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.chemosphere.2018.04.042","article-title":"The persistence of a broad range of antibiotics during calve, pig and broiler manure storage","volume":"204","author":"Berendsen","year":"2018","journal-title":"Chemosphere"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fvets.2018.00254","article-title":"Chicken Gut Microbiota: Importance and Detection Technology","volume":"5","author":"Shang","year":"2018","journal-title":"Front. Vet. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.anifeedsci.2018.10.008","article-title":"The effect of microbiome modulation on the intestinal health of poultry","volume":"250","author":"Kogut","year":"2018","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1007\/s00253-014-5646-2","article-title":"Microbiota of the Chicken Gastrointestinal Tract: Influence on Health, Productivity and Disease","volume":"98","author":"Stanley","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1111\/1750-3841.13921","article-title":"In Vitro Assessment of Bioactivities of Lactobacillus Strains as Potential Probiotics for Humans and Chickens","volume":"82","author":"Shokryazdan","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.14202\/vetworld.2019.1251-1255","article-title":"Studies on immune response to Newcastle disease virus in broiler chickens fed with Lactobacillus reuteri PIA16 isolated from the gut of indigenous chicken of Assam, India","volume":"12","author":"Gonmei","year":"2019","journal-title":"Vet. World"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1016\/j.psj.2020.07.017","article-title":"Effects of a probiotic on the growth performance, intestinal flora, and immune function of chicks infected with Salmonella pullorum","volume":"99","author":"Chen","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/jpn.13124","article-title":"Evaluating two multistrain probiotics on growth performance, intestinal morphology, lipid oxidation and ileal microflora in chickens","volume":"103","author":"Kazemi","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.5713\/ajas.2011.11334","article-title":"Growth Performance and Meat Quality of Broiler Chickens Supplemented with Bacillus licheniformis in Drinking Water","volume":"25","author":"Liu","year":"2012","journal-title":"Asian-Australasian J. Anim. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tvjl.2010.03.003","article-title":"An update on alternatives to antimicrobial growth promoters for broilers","volume":"187","author":"Huyghebaert","year":"2011","journal-title":"Vet. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fmicb.2019.00057","article-title":"Benefits and Inputs from Lactic Acid Bacteria and Their Bacteriocins as Alternatives to Antibiotic Growth Promoters during Food-Animal Production","volume":"10","author":"Belguesmia","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.intimp.2015.07.024","article-title":"A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens","volume":"29","author":"Wang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Shokryazdan, P., Jahromi, M.F., Liang, J.B., Ramasamy, K., Sieo, C.C., and Ho, Y.W. (2017). Effects of a Lactobacillus salivarius mixture on performance, intestinal health and serum lipids of broiler chickens. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175959"},{"key":"ref_17","first-page":"1887","article-title":"Influence of Lactobacillus reuteri SL001 on intestinal microbiota in AD model mice and C57BL\/6 mice","volume":"36","author":"Liu","year":"2020","journal-title":"Chin. J. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of General 16S Ribosomal RNA Gene PCR Primers for Classical and Next-Generation Sequencing-Based Diversity Studies","volume":"41","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: Fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Salzberg","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13568-020-00989-6","article-title":"Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry","volume":"10","author":"Khalique","year":"2020","journal-title":"AMB Express"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1016\/j.psj.2020.09.073","article-title":"Highly nutritious diet resists Salmonella typhimurium infections by improving intestinal microbiota and morphology in broiler chickens","volume":"99","author":"He","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/ps\/79.6.886","article-title":"Digestive and Bacterial Enzyme Activities in Broilers Fed Diets Supplemented with Lactobacillus Cultures","volume":"79","author":"Jin","year":"2000","journal-title":"Poult. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/jsfa.3214","article-title":"Growth performance, nutrient digestibility and immune response of broiler chicks fed diets supplemented with a culture of Lactobacillus bulgaricus","volume":"88","author":"Apata","year":"2008","journal-title":"J. Sci. Food Agric."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s11250-019-01935-w","article-title":"Effects of probiotic lactic acid bacteria on growth performance, carcass characteristics, hematological indices, humoral immunity, and IGF-I gene expression in broiler chicken","volume":"51","author":"Salehizadeh","year":"2019","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.aninu.2021.03.008","article-title":"Probiotic Paenibacillus polymyxa 10 and Lactobacillus plantarum 16 enhance growth performance of broilers by improving the intestinal health","volume":"7","author":"Wang","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12602-020-09640-z","article-title":"Probiotics: An Antibiotic Replacement Strategy for Healthy Broilers and Productive Rearing","volume":"13","author":"Neveling","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73607","DOI":"10.18632\/oncotarget.12437","article-title":"Chicken GHR natural antisense transcript regulates GHR mRNA in LMH cells","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.aninu.2015.07.003","article-title":"Novel probiotics: Their effects on growth performance, gut development, microbial community and activity of broiler chickens","volume":"1","author":"Olnood","year":"2015","journal-title":"Anim. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/jn\/127.10.2039","article-title":"Dietary Fish Oil Alters Specific and Inflammatory Immune Responses in Chicks","volume":"127","author":"Korver","year":"1997","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3390\/nu5061869","article-title":"Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology","volume":"5","author":"Hardy","year":"2013","journal-title":"Nutrients"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.aninu.2022.06.008","article-title":"Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody","volume":"10","author":"Ren","year":"2022","journal-title":"Anim. Nutr."},{"key":"ref_33","first-page":"e13433","article-title":"Effect of probiotic supplementation on growth performance, intestinal morphology, barrier integrity, and inflammatory response in broilers subjected to cyclic heat stress","volume":"91","author":"Li","year":"2020","journal-title":"Anim. Sci. J. Nihon Chikusan Gakkaiho"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3382\/ps.2013-03314","article-title":"Effects of multistrain probiotics on growth performance, apparent ileal nutrient digestibility, blood characteristics, cecal microbial shedding, and excreta odor contents in broilers","volume":"93","author":"Zhang","year":"2014","journal-title":"Poult. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/09540105.2018.1457013","article-title":"Effects of Clostridium butyricum and Lactobacillus plantarum on growth performance, immune function and volatile fatty acid level of caecal digesta in broilers","volume":"29","author":"Han","year":"2018","journal-title":"Food Agric. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3382\/ps\/pey368","article-title":"Effects of dietary Enterococcus faecium NCIMB 11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens","volume":"98","author":"Wu","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Surai, P.F., Kochish, I.I., Fisinin, V.I., and Kidd, M.T. (2019). Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update. Antioxidants, 8.","DOI":"10.3390\/antiox8070235"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3382\/ps\/pew246","article-title":"Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens","volume":"96","author":"Bai","year":"2017","journal-title":"Poult. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1365-2672.2009.04294.x","article-title":"Free radical scavenging activity of Lactobacillus fermentum in vitro and its antioxidative effect on growing-finishing pigs","volume":"107","author":"Wang","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/jam.14189","article-title":"In vitro selection and in vivo confirmation of the antioxidant ability of Lactobacillus brevis MG 000874","volume":"126","author":"Noureen","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00217-010-1255-1","article-title":"The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats","volume":"231","author":"Zhang","year":"2010","journal-title":"Eur. Food Res. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.3382\/ps\/pex172","article-title":"Dietary effects of Bacillus subtilis fmbj on the antioxidant capacity of broilers at an early age","volume":"96","author":"Zhang","year":"2017","journal-title":"Poult. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"He, T., Long, S., Mahfuz, S., Wu, D., Wang, X., Wei, X., and Piao, X. (2019). Effects of Probiotics as Antibiotics Substitutes on Growth Performance, Serum Biochemical Parameters, Intestinal Morphology, and Barrier Function of Broilers. Animals, 9.","DOI":"10.3390\/ani9110985"},{"key":"ref_44","first-page":"1561","article-title":"Effects of three probiotic Bacillus on growth performance, digestive enzyme activities, antioxidative capacity, serum immunity, and biochemical parameters in broilers","volume":"89","author":"Gong","year":"2018","journal-title":"Anim. Sci. J. Nihon Chikusan Gakkaiho"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.aninu.2020.03.002","article-title":"Dietary synbiotic supplementation improves the growth performance, body antioxidant pool, serum biochemistry, meat quality, and lipid oxidative stability in broiler chickens","volume":"6","author":"Dev","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"\u017bbikowski, A., Paw\u0142owski, K., \u015ali\u017cewska, K., Dolka, B., Nerc, J., and Szeleszczuk, P. (2020). Comparative Effects of Using New Multi-Strain Synbiotics on Chicken Growth Performance, Hematology, Serum Biochemistry and Immunity. Animals, 10.","DOI":"10.3390\/ani10091555"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1939-165X.2002.tb00295.x","article-title":"Clinical Chemistry of Companion Avian Species: A Review","volume":"31","author":"Harr","year":"2002","journal-title":"Vet. Clin. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.livsci.2018.08.008","article-title":"Efficacy of yeast and multi-strain probiotic alone or in combination on growth performance, carcass traits, blood biochemical constituents, and meat quality of broiler chickens","volume":"216","author":"Hussein","year":"2018","journal-title":"Livest. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/j.psj.2020.01.028","article-title":"Dietary calcium or phosphorus deficiency impairs the bone development by regulating related calcium or phosphorus metabolic utilization parameters of broilers","volume":"99","author":"Li","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3382\/ps\/pex401","article-title":"High calcium to phosphorus ratio impairs growth and bone mineralization in Pekin ducklings","volume":"97","author":"Zhu","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00284-020-01903-w","article-title":"Cholesterol-Lowering Effects of Lactobacillus Species","volume":"77","author":"Khare","year":"2020","journal-title":"Curr. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Alaqil, A.A., Abbas, A.O., El-Beltagi, H.S., El-Atty, H.K.A., Mehaisen, G.M.K., and Moustafa, E.S. (2020). Dietary Supplementation of Probiotic Lactobacillus acidophilus Modulates Cholesterol Levels, Immune Response, and Productive Performance of Laying Hens. Animals, 10.","DOI":"10.3390\/ani10091588"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/1828051X.2020.1801359","article-title":"Effects of dietary extruded linseed and Lactobacillus acidophilus on growth performance, carcass traits, plasma lipoprotein response, and caecal bacterial populations in broiler chicks","volume":"19","author":"Gheorghe","year":"2020","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1016\/j.psj.2020.03.057","article-title":"Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens","volume":"99","author":"Jiang","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.aninu.2021.01.009","article-title":"Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells","volume":"7","author":"Xu","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2478\/aoas-2018-0059","article-title":"The Effect of a Probiotic Preparation Containing Bacillus subtilis PB6 in the Diet of Chickens on Redox and Biochemical Parameters in Their Blood","volume":"19","author":"Abramowicz","year":"2019","journal-title":"Ann. Anim. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.rvsc.2010.03.009","article-title":"Effect of probiotic on growth performance and digestive enzyme activity of Arbor Acres broilers","volume":"89","author":"Wang","year":"2010","journal-title":"Res. Vet. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13567-018-0538-6","article-title":"Biomarkers for monitoring intestinal health in poultry: Present status and future perspectives","volume":"49","author":"Ducatelle","year":"2018","journal-title":"Vet. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Rodrigues, D.R., Briggs, W., Duff, A., Chasser, K., Murugesan, R., Pender, C., Ramirez, S., Valenzuela, L., and Bielke, L.R. (2020). Comparative effectiveness of probiotic-based formulations on cecal microbiota modulation in broilers. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0225871"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15358","DOI":"10.1038\/s41598-018-33762-8","article-title":"Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens","volume":"8","author":"Ma","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1038\/s41598-017-06677-z","article-title":"Effect of probiotics on the meat flavour and gut microbiota of chicken","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00019-15","article-title":"Taxonomy, Physiology, and Natural Products of Actinobacteria","volume":"80","author":"Barka","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"16259","DOI":"10.1038\/s41598-020-73316-5","article-title":"Competitive reduction of poultry-borne enteric bacterial pathogens in chicken gut with bioactive Lactobacillus casei","volume":"10","author":"Tabashsum","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1038\/ncomms10391","article-title":"Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis","volume":"7","author":"Dubin","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/10\/1690\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:38:12Z","timestamp":1760125092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/10\/1690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["ani13101690"],"URL":"https:\/\/doi.org\/10.3390\/ani13101690","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]}}}