{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:45:13Z","timestamp":1773967513689,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SEGES Innovation P\/S"},{"name":"Pig Levy Fund"},{"name":"R. N\u00f8rtoft Thomsen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The objective was to study the effects of weaning in week 5 (W5) vs. week 4 (W4), as well as liquid (LF) vs. dry feed (DF), on growth performance, disaccharidase activity and nutrient transporter expression after weaning. The experiment included 12,923 pigs fed LF or DF in the pre-weaning period and a subpopulation of 15 pigs from each group, W4DF, W4LF, W5DF and W5LF, which were weighed and euthanized five days after weaning. The proximal part of the small intestine was analyzed for maltase, lactase and sucrase activity and the expression of SGLT-1, GLUT-2 and PepT-1. Pigs fed LF displayed less maltase activity (2100 vs. 2729 U\/mg protein, p &lt; 0.05) but an increased expression of SGLT-1 (\u2206Ct: 5.22 vs. 6.21, p = 0.01). Pigs weaned in W5 were heavier than those weaned in W4 (9.35 vs. 7.11 kg BW, p \u2264 0.05), and pigs fed LF were heavier than those fed DF (8.55 vs. 7.91 kg BW, p \u2264 0.05) five days after weaning in the subpopulation. LF pigs (21.8 kg) were heavier than DF pigs (20.6 kg) (SE 0.108, p &lt; 0.0001), and W4 pigs (21.0 kg) were lighter than W5 pigs (21.5 kg) (SE 0.108, p = 0.01) at nine weeks. LF increased weight gain in the early post-weaning period and at nine weeks, although this was apparently not explained by accelerated gut maturation.<\/jats:p>","DOI":"10.3390\/ani13111851","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T01:33:54Z","timestamp":1685669634000},"page":"1851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Weaning Age and Creep Feed Type on Growth Performance and Gut Maturation in Weaned Piglets"],"prefix":"10.3390","volume":"13","author":[{"given":"Kimmie Kyed","family":"Lyderik","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels J\u00f8rgen","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"SEGES Innovation P\/S, Axeltorv 3, 1609 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Louise Madelung","family":"Pedersen","sequence":"additional","affiliation":[{"name":"SEGES Innovation P\/S, Axeltorv 3, 1609 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-4405","authenticated-orcid":false,"given":"Mette Skou","family":"Hedemann","sequence":"additional","affiliation":[{"name":"Department of Animal and Veterinary Sciences, Faculty of Technical Sciences, Aarhus University, Blichers Alle 20, 8830 Tjele, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-282X","authenticated-orcid":false,"given":"Andrew Richard","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-4200","authenticated-orcid":false,"given":"Charlotte","family":"Amdi","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7528-9521","authenticated-orcid":false,"given":"Johannes Gulmann","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Gr\u00f8nneg\u00e5rdsvej 2, 1870 Frederiksberg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.anifeedsci.2011.12.022","article-title":"Nutrition and pathology of weaner pigs: Nutritional strategies to support barrier function in the gastrointestinal tract","volume":"173","author":"Kim","year":"2012","journal-title":"Anim. 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