{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:19:47Z","timestamp":1760149187694,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science, Technology, and Innovation Funding Authority (STDF), Egypt","doi-asserted-by":"publisher","award":["38182"],"award-info":[{"award-number":["38182"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study aimed to evaluate the productive performance and microbiota variation in the jejunum and cecum of two rabbit breeds with different growth rates. This study was carried out on Native Middle-Egypt Breed (NMER) and Giant Flanders (GF) rabbits from 5 weeks to 12 weeks of age. Twenty NMER (NM) and GF male rabbits were slaughtered, and the jejunum and cecum tracts were collected to assay gut microbiota composition via 16S ribosomal RNA (rRNA) gene sequencing and histology examination. At 12 weeks of age, daily weight gain, villus height in the jejunum, total protein, and albumin were higher in GF rabbits than in NMER rabbits. Also, the jejunal villi of GF were well arranged in their dense borders. The microbiota between the jejunum and cecum was significantly different in terms of Beta-diversity. A significant correlation between Enterococcus (jejunum NM samples) and Lactobacillus (cecum GF samples) with body weight and weight gain was found (p &lt; 0.05). Moreover, Escherichia-Shigella in the cecum of NM was significantly correlated with weight gain (p &lt; 0.05). The most abundant genera identified in the jejunal and cecal contents of GF were generally beneficial microbiota. They may also play a role in reducing the pathogenic effects of Escherichia coli in these rabbits.<\/jats:p>","DOI":"10.3390\/ani13142294","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:39:41Z","timestamp":1689295181000},"page":"2294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diversity and Co-Occurrence Pattern Analysis of Cecal and Jejunal Microbiota in Two Rabbit Breeds"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-4080","authenticated-orcid":false,"given":"El-Sayed M.","family":"Abdel-Kafy","sequence":"first","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel I.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-1206","authenticated-orcid":false,"given":"Marco","family":"Severgnini","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Technologies, National Research Council (ITB-CNR), Via f.lli Cervi, 93, 20054 Segrate, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shama H. A.","family":"Morsy","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-5549","authenticated-orcid":false,"given":"Paola","family":"Cremonesi","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Biology and Biotechnology, National Research Council (IBBA-CNR), Via Einstein s\/n, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen S.","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-2801","authenticated-orcid":false,"given":"Gabriele","family":"Brecchia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Milano, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neama I.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Biotechnology Research Institute, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmein Z.","family":"Abdel-Ghafar","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A. H.","family":"Ali","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda M. A.","family":"Shabaan","sequence":"additional","affiliation":[{"name":"Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Giza 12651, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.chom.2018.03.011","article-title":"Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids","volume":"23","author":"Hubert","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_2","first-page":"961","article-title":"Gut microbiota and development of the immune system","volume":"32","year":"2016","journal-title":"Med. Sci. M\/S"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Allam-Ndoul, B., Castonguay-Paradis, S., and Veilleux, A. (2020). Gut microbiota and intestinal trans-epithelial permeability. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176402"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Sperandio","year":"2016","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.1038\/s41598-018-30932-6","article-title":"Characterization of bacterial microbiota compositions along the intestinal tract in pigs and their interactions and functions","volume":"8","author":"Revilla","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"712226","DOI":"10.3389\/fvets.2021.712226","article-title":"The spatial and temporal characterization of gut microbiota in broilers","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2460\/ajvr.79.8.811","article-title":"Characterization of the fecal microbiota of healthy horses","volume":"79","author":"Stewart","year":"2018","journal-title":"Am. J. Vet. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, J., Xia, S., Fan, H., Shao, J., Tang, T., Yang, L., Sun, W., Jia, X., Chen, S., and Lai, S. (2022). Microbiomics revealed the disturbance of intestinal balance in rabbits with diarrhea caused by stopping the use of an antibiotic diet. Microorganisms, 10.","DOI":"10.3390\/microorganisms10050841"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fvets.2019.00201","article-title":"Development of the caecal microbiota in three broiler breeds","volume":"6","author":"Richards","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8510","DOI":"10.1038\/s41598-018-26930-3","article-title":"Variation in faecal microbiota in a group of horses managed at pasture over a 12-month period","volume":"8","author":"Salem","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_12","unstructured":"AVMA (2018). Avma Pet Ownership and Demographics Sourcebook: 2017\u20132018 Edition, AVMA."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cotozzolo, E., Cremonesi, P., Curone, G., Menchetti, L., Riva, F., Biscarini, F., Marongiu, M.L., Castrica, M., Castiglioni, B., and Miraglia, D. (2020). Characterization of bacterial microbiota composition along the gastrointestinal tract in rabbits. Animals, 11.","DOI":"10.3390\/ani11010031"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-021-02377-x","article-title":"Rabbit microbiota across the whole body revealed by 16s rrna gene amplicon sequencing","volume":"21","author":"Hu","year":"2021","journal-title":"BMC Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-018-1464-6","article-title":"Comparison of the fecal microbiota of domestic commercial meat, laboratory, companion, and shelter rabbits (oryctolagus cuniculi)","volume":"14","author":"Kylie","year":"2018","journal-title":"BMC Vet. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19495","DOI":"10.1038\/s41598-021-99028-y","article-title":"The value of gut microbiota to predict feed efficiency and growth of rabbits under different feeding regimes","volume":"11","author":"Piles","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41598-018-36534-6","article-title":"Gut microbiota profiling with differential tolerance against the reduced dietary fibre level in rabbit","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Agradi, S., Cremonesi, P., Menchetti, L., Balzaretti, C., Severgnini, M., Riva, F., Castiglioni, B., Draghi, S., Di Giancamillo, A., and Castrica, M. (2023). Bovine colostrum supplementation modulates the intestinal microbial community in rabbits. Animals, 13.","DOI":"10.3390\/ani13060976"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Curone, G., Biscarini, F., Cotozzolo, E., Menchetti, L., Dal Bosco, A., Riva, F., Cremonesi, P., Agradi, S., Mattioli, S., and Castiglioni, B. (2022). Could dietary supplementation with different sources of n-3 polyunsaturated fatty acids modify the rabbit gut microbiota?. Antibiotics, 11.","DOI":"10.3390\/antibiotics11020227"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cremonesi, P., Curone, G., Biscarini, F., Cotozzolo, E., Menchetti, L., Riva, F., Marongiu, M.L., Castiglioni, B., Barbato, O., and Munga, A. (2022). Dietary supplementation with goji berries (lycium barbarum) modulates the microbiota of digestive tract and caecal metabolites in rabbits. Animals, 12.","DOI":"10.3390\/ani12010121"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, Q., Fu, W., Guo, Y., Tang, Y., Du, H., Wang, M., Liu, Z., Li, Q., An, L., and Tian, J. (2019). Drinking warm water improves growth performance and optimizes the gut microbiota in early postweaning rabbits during winter. Animals, 9.","DOI":"10.3390\/ani9060346"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1574-6941.2011.01148.x","article-title":"Postnatal development of the rabbit caecal microbiota composition and activity","volume":"77","author":"Combes","year":"2011","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/1751-7915.13485","article-title":"Faecal microbiota and functional capacity associated with weaning weight in meat rabbits","volume":"12","author":"Fang","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3389\/fmicb.2019.00973","article-title":"Diversity and co-occurrence pattern analysis of cecal microbiota establishment at the onset of solid feeding in young rabbits","volume":"10","author":"Read","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1051\/animres:2001135","article-title":"Impact of fibre deficiency and sanitary status on non-specific enteropathy of the growing rabbit","volume":"50","author":"Bennegadi","year":"2001","journal-title":"Anim. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1365-2672.2007.03309.x","article-title":"The effect of medicated diets and level of feeding on caecal microbiota of lactating rabbit does","volume":"103","author":"Abecia","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13568-016-0273-1","article-title":"Illumina miseq platform analysis caecum bacterial communities of rex rabbits fed with different antibiotics","volume":"6","author":"Zou","year":"2016","journal-title":"AMB Express"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"849429","DOI":"10.3389\/fnut.2022.849429","article-title":"Gut microbiota modulate rabbit meat quality in response to dietary fiber","volume":"9","author":"Liu","year":"2022","journal-title":"Front Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Castrica, M., Menchetti, L., Agradi, S., Curone, G., Vigo, D., Pastorelli, G., Di Giancamillo, A., Modina, S.C., Riva, F., and Serra, V. (2022). Effect of bovine colostrum dietary supplementation on rabbit meat quality. Foods, 11.","DOI":"10.3390\/foods11213433"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108018","DOI":"10.1016\/j.meatsci.2019.108018","article-title":"The effect of goji berries (lycium barbarum) dietary supplementation on rabbit meat quality","volume":"161","author":"Menchetti","year":"2020","journal-title":"Meat Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-020-02732-6","article-title":"Effect of host breeds on gut microbiome and serum metabolome in meat rabbits","volume":"17","author":"Ye","year":"2021","journal-title":"BMC Vet. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Alshamy, Z., Richardson, K.C., Hunigen, H., Hafez, H.M., Plendl, J., and Al Masri, S. (2018). Comparison of the gastrointestinal tract of a dual-purpose to a broiler chicken line: A qualitative and quantitative macroscopic and microscopic study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204921"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-13-31","article-title":"Pandaseq: Paired-end assembler for illumina sequences","volume":"13","author":"Masella","year":"2012","journal-title":"BMC Bioinform."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"Qiime allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive bayesian classifier for rapid assignment of rrna sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The silva ribosomal rna gene database project: Improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1093\/bioinformatics\/btv287","article-title":"Tax4fun: Predicting functional profiles from metagenomic 16s rrna data","volume":"31","author":"Wemheuer","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_40","first-page":"62","article-title":"Genetic evaluation for growth traits in new synthetic rabbit line in egypt","volume":"1","author":"Shabaan","year":"2021","journal-title":"Open J. Agric. Res."},{"key":"ref_41","first-page":"1312","article-title":"Genetic diversity and phenotype characterization of native rabbitin middle-egypt","volume":"16","author":"Benlarbi","year":"2016","journal-title":"J. New Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4995\/wrs.2020.12937","article-title":"Comparison of exterior traits in selected giant and medium rabbit breeds","volume":"28","author":"Zigo","year":"2020","journal-title":"World Rabbit Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4995\/wrs.2010.18.13","article-title":"Haematological and biochemical observations in four pure breeds of rabbits and their crosses under egyptian environmental conditions","volume":"18","author":"Darwish","year":"2010","journal-title":"World Rabbit Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"284","DOI":"10.21608\/zvjz.2020.28446.1107","article-title":"Breed effects on growth performance, blood parameters and the levels of metabolic hormones in rabbits under heat stress in egypt","volume":"48","author":"Dawod","year":"2020","journal-title":"Zagazig Vet. J."},{"key":"ref_45","unstructured":"Ramakrishnan, S. (2004). Textbook of Medical Biochemistry, Orient Blackswan."},{"key":"ref_46","first-page":"54","article-title":"Functional, anatomical and histological development of caecum in rabbits","volume":"1","author":"Kalaba","year":"2011","journal-title":"Curr. Res. Poult. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/iai.19.2.686-694.1978","article-title":"Scanning and transmission electron microscopic study of escherichia coli 015 (rdec-1) enteric infection in rabbit","volume":"19","author":"Takeuchi","year":"1978","journal-title":"Infect. Immun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3389\/fmicb.2018.00733","article-title":"Microbiome of total versus live bacteria in the gut of rex rabbits","volume":"9","author":"Fu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Xiang, X.-D., Deng, Z.-C., Wang, Y.-W., Sun, H., Wang, L., Han, Y.-M., Wu, Y.-Y., Liu, J.-G., and Sun, L.-H. (2021). Organic acids improve growth performance with potential regulation of redox homeostasis, immunity, and microflora in intestines of weaned piglets. Antioxidants, 10.","DOI":"10.3390\/antiox10111665"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2527\/jas.2013-6755","article-title":"Regulation of n-acetyl cysteine on gut redox status and major microbiota in weaned piglets","volume":"92","author":"Xu","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"771826","DOI":"10.3389\/fimmu.2021.771826","article-title":"Clostridium butyricum alleviates enterotoxigenic escherichia coli k88-induced oxidative damage through regulating the p62-keap1-nrf2 signaling pathway and remodeling the cecal microbial community","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Adewole, D., and Akinyemi, F. (2021). Gut microbiota dynamics, growth performance, and gut morphology in broiler chickens fed diets varying in energy density with or without bacitracin methylene disalicylate (bmd). Microorganisms, 9.","DOI":"10.3390\/microorganisms9040787"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1053\/j.gastro.2014.01.052","article-title":"Compositional and functional features of the gastrointestinal microbiome and their effects on human health","volume":"146","author":"Hollister","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3389\/fimmu.2019.01486","article-title":"Short chain fatty acids (scfas)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/AAC.01528-15","article-title":"Carriage of enterobacteria producing extended-spectrum \u03b2-lactamases and composition of the gut microbiota in an amerindian community","volume":"60","author":"Gosalbes","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1128\/AEM.06466-11","article-title":"Genomic and physiological characterization of the verrucomicrobia isolate diplosphaera colitermitum gen. Nov., sp. Nov., reveals microaerophily and nitrogen fixation genes","volume":"78","author":"Wertz","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16643","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1365-2672.2004.02191.x","article-title":"Characterization of faecal enterococci from rabbits for the selection of probiotic strains","volume":"96","author":"Linaje","year":"2004","journal-title":"J. Appl. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12602-019-09578-x","article-title":"The application of lactobacillus reuteri ccm 8617 and flaxseed positively improved the health of mice challenged with enterotoxigenic E. coli o149: F4","volume":"12","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3389\/fmicb.2018.02144","article-title":"Rabbit microbiota changes throughout the intestinal tract","volume":"9","author":"Piles","year":"2018","journal-title":"Front. Microbiol."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/14\/2294\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:12:08Z","timestamp":1760127128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/14\/2294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":60,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["ani13142294"],"URL":"https:\/\/doi.org\/10.3390\/ani13142294","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}