{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:22:27Z","timestamp":1760149347110,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: A high perinatal mortality rate in the Stabyhoun breed prompted one of the Dutch breeding organizations to start an investigation. Preductal segmental tubular aortic hypoplasia is an extremely rarely documented congenital vascular anomaly in dogs, and it is suspected to be the result of constriction of ectopic ductal tissue in the aortic wall at birth. Methods: Over a period of 18 months, Stabyhoun puppies that were stillborn, died or were euthanized before 3 weeks of age were submitted to post-mortem examination at the reporting institution. Pathologic findings were documented. Results: Eight Stabyhoun puppies were submitted during the study period. In five of them, a severe preductal segmental tubular aortic hypoplasia was found. Two of the five puppies were stillborn, and three died spontaneously or were euthanized. Conclusions: Preductal tubular aortic hypoplasia was found in an unusually high frequency in the examined Stabyhoun puppies. Because the condition is believed to cause clinical signs only after birth, this anomaly cannot explain the death of the stillborn puppies. However, it might be responsible for cardiogenic pulmonary edema in the postnatal period. Routine dissection of the great vessels in perinatally deceased puppies would help to establish the prevalence of congenital anomalies of the aorta.<\/jats:p>","DOI":"10.3390\/ani13152423","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T01:56:16Z","timestamp":1690509376000},"page":"2423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preductal Segmental Tubular Aortic Hypoplasia in Perinatally Died Stabyhoun Puppies"],"prefix":"10.3390","volume":"13","author":[{"given":"Marie D. B.","family":"van Staveren","sequence":"first","affiliation":[{"name":"Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-9648","authenticated-orcid":false,"given":"Guy C. M.","family":"Grinwis","sequence":"additional","affiliation":[{"name":"Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein L.","family":"den Toom","sequence":"additional","affiliation":[{"name":"Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-6586","authenticated-orcid":false,"given":"Viktor","family":"Szatm\u00e1ri","sequence":"additional","affiliation":[{"name":"Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e0230160","DOI":"10.1371\/journal.pone.0230160","article-title":"Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice","volume":"15","author":"Brambilla","year":"2020","journal-title":"PLoS ONE"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/jvim.12267","article-title":"Long-term outcome in dogs with patent ductus arteriosus: 520 cases (1994\u20132009)","volume":"28","author":"Saunders","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"den Toom, M.L., Meiling, A.E., Thomas, R.E., Leegwater, P.A., and Heuven, H.C. (2016). Epidemiology, presentation and population genetics of patent ductus arteriosus (PDA) in the Dutch Stabyhoun dog. BMC Vet. Res., 12.","DOI":"10.1186\/s12917-016-0720-x"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/hrt.41.3.268","article-title":"Coarctation, tubular hypoplasia, and the ductus arteriosus. Histological study of 35 specimens","volume":"41","author":"Ho","year":"1979","journal-title":"Br. Heart J."},{"key":"ref_5","first-page":"289","article-title":"Coarctation and other obstructive aortic arch anomalies: Their relationship to the ductus arteriosus","volume":"13","author":"Elzenga","year":"1986","journal-title":"Interv. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.hlc.2014.08.006","article-title":"Hypoplasia, pseudocoarctation and coarctation of the aorta\u2014A systematic review","volume":"24","author":"Singh","year":"2015","journal-title":"Heart Lung Circ."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.athoracsur.2015.09.050","article-title":"Diagnosing neonatal aortic coarctation in the setting of patent ductus arteriosus","volume":"101","author":"Peng","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12576-016-0512-x","article-title":"Pathology and molecular mechanism of coarctation of the aorta and its association with the ductus arteriosus","volume":"67","author":"Yokoyama","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/1089253219873004","article-title":"Preoperative physiology, imaging, and management of coarctation of aorta in children","volume":"23","author":"Ganigara","year":"2019","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e012877","DOI":"10.1161\/CIRCIMAGING.121.012877","article-title":"Aortic coarctation: The fetal cardiologist\u2019s Achilles heel","volume":"14","author":"Hornberger","year":"2021","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1638\/1042-7260(2001)032[0111:PACAPD]2.0.CO;2","article-title":"Preductal aortic coarctation and patent ductus arteriosus in a Sumatran tiger (Panthera tigris sumatrae) cub","volume":"32","author":"Barnes","year":"2001","journal-title":"J. Zoo. Wildl. Med."},{"key":"ref_12","first-page":"536","article-title":"Tubular hypoplasia of the ascending aorta and patent ductus arteriosus in a dog","volume":"176","author":"Sandusky","year":"1980","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/104063871002200433","article-title":"Tubular hypoplasia of the aorta and right atrioventricular valve dysplasia in a bulldog","volume":"22","author":"Robinson","year":"2010","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jvc.2020.08.001","article-title":"Sudden death in a dog with aortic coarctation","volume":"31","author":"Fox","year":"2020","journal-title":"J. Vet. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.theriogenology.2011.12.023","article-title":"Canine perinatal mortality: A cohort study of 224 breeds","volume":"77","author":"Tonessen","year":"2012","journal-title":"Theriogenology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.theriogenology.2019.07.027","article-title":"Incidence of congenital malformations and impact on the mortality of neonatal canines","volume":"140","year":"2019","journal-title":"Theriogenology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S1466252321000128","article-title":"Guidelines for postmortem examination of newborn dogs","volume":"22","author":"Mila","year":"2021","journal-title":"Anim. Health Res. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0735-1097(85)80178-9","article-title":"Histologic studies on normal and persistent ductus arteriosus in the dog","volume":"6","author":"Strengers","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1939-1676.2003.tb02429.x","article-title":"Etiology of patent ductus arteriosus in dogs","volume":"17","author":"Buchanan","year":"2003","journal-title":"J. Vet. Intern. Med."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/15\/2423\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:20:32Z","timestamp":1760127632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/15\/2423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":19,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ani13152423"],"URL":"https:\/\/doi.org\/10.3390\/ani13152423","relation":{},"ISSN":["2076-2615"],"issn-type":[{"type":"electronic","value":"2076-2615"}],"subject":[],"published":{"date-parts":[[2023,7,27]]}}}