{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:43:21Z","timestamp":1766731401072,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FI predoctoral fellowship","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]},{"name":"Instituto de Salud Carlos III Spain","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]},{"name":"\/AEI\/10.13039\/501100011033","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 de TV3","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]},{"name":"National Institutes of Health","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]},{"name":"\u201cla Caixa\u201d Foundation","award":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"],"award-info":[{"award-number":["2023 FI-3 00034","MS20\/00064","PID2019-104700GA-I00","202230-30","R01HG010898-01","100010434"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. Primary tauopathies are not uncommon in humans but exceptional in other species. We evaluate the clinical, neuropathological, and genetic alterations related to tau pathology in 16 cats aged from 1 to 21 years with different clinical backgrounds. Interestingly, a 10-year-old female cat presented a six-year progressive history of mental status and gait abnormalities. The imaging study revealed generalized cortical atrophy. Due to the poor prognosis, the cat was euthanatized at the age of ten. Neuropathological lesions were characterized by massive neuronal loss with marked spongiosis and associated moderate reactive gliosis in the parietal cortex, being less severe in other areas of the cerebral cortex, and the loss of Purkinje cells of the cerebellum. Immunohistochemical methods revealed a 4R-tauopathy with granular pre-tangles in neurons and coiled bodies in oligodendrocytes. Deposits were recognized with several phospho-site antibodies (4Rtau, tau5, AT8, PFH, tau-P Thr181, tau-P-Ser 262, tau-P Ser 422) and associated with increased granular expression of active tau kinases (p38-P Thr180\/Tyr182 and SAPK\/JNK-P Thr138\/Thr185). The genetic study revealed well-preserved coding regions of MAPT. No similar alterations related to tau pathology were found in the other 15 cats processed in parallel. To our knowledge, this is the first case reporting a primary 4R-tauopathy with severe cerebral and Purkinje cell degeneration in an adult cat with neurological signs starting at a young age.<\/jats:p>","DOI":"10.3390\/ani13182985","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:53:05Z","timestamp":1695271985000},"page":"2985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-753X","authenticated-orcid":false,"given":"Laura","family":"Vidal-Palencia","sequence":"first","affiliation":[{"name":"Hospital del Mar Research Institute, Parc de Recerca Biom\u00e8dica de Barcelona (PRBB), 08003 Barcelona, Spain"},{"name":"Unitat de Patologia Murina i Comparada, Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Campus UAB, Travessera dels Turons s\/n, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Font","sequence":"additional","affiliation":[{"name":"Hospital Veterinari Canis, Can Pau Birol, 38, 17006 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-2713","authenticated-orcid":false,"given":"Agust\u00edn","family":"Rebollada-Merino","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Department of Internal Medicine and Animal Surgery, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-8637","authenticated-orcid":false,"given":"Gabriel","family":"Santpere","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute, Parc de Recerca Biom\u00e8dica de Barcelona (PRBB), 08003 Barcelona, Spain"},{"name":"Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06511, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-0338","authenticated-orcid":false,"given":"Pol","family":"Andr\u00e9s-Benito","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), 08908 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-8754","authenticated-orcid":false,"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), 08908 Barcelona, Spain"},{"name":"Department of Pathology and Experimental Therapeutics, University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-7941","authenticated-orcid":false,"given":"Mart\u00ed","family":"Pumarola","sequence":"additional","affiliation":[{"name":"Unitat de Patologia Murina i Comparada, Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Campus UAB, Travessera dels Turons s\/n, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nan.12200","article-title":"Invited Review: Animal Models of Tauopathies and Their Implications for Research\/Translation into the Clinic","volume":"41","author":"Dujardin","year":"2015","journal-title":"Neuropathol. 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