{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:51:38Z","timestamp":1791571898010,"version":"4.3.4"},"reference-count":62,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Agriculture and Rural Affairs of Hunan Province, the Construction of Modern Agricultural Industrial Technology System in Hunan Province","award":["Hunan Financial Agriculture Guide 2019 [97]"],"award-info":[{"award-number":["Hunan Financial Agriculture Guide 2019 [97]"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Cadmium (Cd) is an environmental pollutant, widely existing in soil, and can be absorbed and accumulated by plants. Hunan Province exhibits the worst cadmium contamination of farmland in China. Ruminants possess an abundant microbial population in the rumen, which enables them to tolerate various poisonous plants. To investigate whether the rumen microbiota could respond to Cd and mitigate the toxicity of Cd-accumulated maize to ruminants, 6-month-old cattle were fed with 85.82% (fresh basis) normal whole-plant maize silage diet (CON, n = 10) or Cd-accumulated whole-plant maize silage diet (CAM, n = 10) for 107 days. When compared to the CON cattle, CAM cattle showed significantly higher gain-to-feed ratio and an increased total bacterial population in the rumen, but a decreased total bacterial population in the colon. CAM cattle had higher relative abundance of Prevotella and Lachnospiraceae ND3007 group in the rumen, and Lachnospiraceae NK4A136 group and Clostridia vadinBB60 group in the colon. Notably, microbial correlations were enhanced in all segments of CAM cattle, especially Peptostreptococcaceae in the jejunum. Transcriptome analysis revealed down-regulation of several immune-related genes in the rumen of CAM cattle, and differentially expressed genes in the rumen were mostly involved in immune regulation. These findings indicated that feeding Cd-accumulated maize diet with a Cd concentration of 6.74 mg\/kg dry matter (DM) could stimulate SCFA-related bacteria in the rumen, induce hormesis to promote weight gain, and improve energy utilization of cattle.<\/jats:p>","DOI":"10.3390\/ani13193104","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:14:22Z","timestamp":1696497262000},"page":"3104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing the Effects of Dietary Cadmium Exposure on the Gastrointestinal Tract of Beef Cattle via Microbiota and Transcriptome Profile"],"prefix":"10.3390","volume":"13","author":[{"given":"Xinxin","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangle","family":"Yi","sequence":"additional","affiliation":[{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Sun","sequence":"additional","affiliation":[{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-6777","authenticated-orcid":false,"given":"Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7213-3721","authenticated-orcid":false,"given":"Jiakun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref_1","unstructured":"International Agency for Research on Cancer (2012). 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