{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:23:40Z","timestamp":1778919820258,"version":"3.51.4"},"reference-count":83,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["NFQS2023002"],"award-info":[{"award-number":["NFQS2023002"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Aquaculture, a crucial sector of the global food industry, faces a myriad of issues due to parasitic invasions. One such parasite, Microcotyle sebastis, which afflicts Korean rockfish in South Korea, has a significant economic impact. The impending danger of resistance to traditional anthelmintics necessitates the exploration of new antiparasitic candidates. Although the efficacy of salinomycin against aquatic parasites such as ciliates and sporozoans is known, its influence on monogeneans has yet to be studied. Therefore, this study investigated the efficacy and safety of salinomycin for the treatment of M. sebastis infections, presenting the first exploration of salinomycin\u2019s therapeutic potential against monogeneans. In vitro examinations revealed a minimum effective concentration of salinomycin of 5 mg\/kg, which led to necrosis of the haptor upon dislodging from the gill filaments. The one-time oral administration of the drug at concentrations of 5 mg\/kg and 10 mg\/kg showed a significant dose-dependent reduction in parasite counts, with no apparent behavioral side effects in Korean rockfish. Biochemical analyses monitored the liver, heart, and kidney enzymes, specifically aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), and creatine kinase\u2013myocardial band (CK-MB). At both 20 \u00b0C and 13 \u00b0C, no significant differences were observed in the levels of AST and ALT. However, at 20 \u00b0C, alterations in BUN levels were evident on Day 14, a deviation not observed at 13 \u00b0C. The CK-MB analysis revealed elevated enzyme levels at both temperatures when compared to the control group, reflecting the similar changes observed in terrestrial animals administered salinomycin. The biochemical data suggest that the oral administration of salinomycin is potentially more favorable at 13 \u00b0C than at 20 \u00b0C. Although our findings warrant further comprehensive studies, including on the long-term and potential effects on nontarget species and water quality, they also suggest that salinomycin could be considered as an alternative or adjunctive treatment if resistance to the currently used praziquantel against M. sebastis is confirmed.<\/jats:p>","DOI":"10.3390\/ani13203233","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:10:19Z","timestamp":1697530219000},"page":"3233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Salinomycin\u2019s Potential to Treat Microcotyle sebastis in Korean Rockfish (Sebastes schlegelii)"],"prefix":"10.3390","volume":"13","author":[{"given":"Won-Sik","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hee","family":"Shim","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyoungsik","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-8935","authenticated-orcid":false,"given":"Kyung-Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha-Jeong","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4597-3781","authenticated-orcid":false,"given":"Min-Young","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-8708","authenticated-orcid":false,"given":"Jaekyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Aquatic Disease Control Division, National Fishery Products Quality Management Service, 216 Gijanghaean-ro, Busan 46083, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mun-Gyeong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Aquatic Disease Control Division, National Fishery Products Quality Management Service, 216 Gijanghaean-ro, Busan 46083, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Aquatic Life Medicine, College of Fisheries Sciences, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Il","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Marine Biology & Aquaculture, Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 2 Tongyeonghaean-ro, Tongyeong 53064, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","unstructured":"FAO (2022). 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