{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:57:16Z","timestamp":1778619436975,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IVC Evidensia\u2019s fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>In this case report, we describe the diagnosis, treatment, and outcome of two feline cases of vertebral osteosarcoma. Case 1: A 6-year-old female neutered domestic longhaired cat was presented with progressive paraparesis, ataxia, and spinal hyperesthesia. MRI of the thoracolumbar spinal cord and vertebral column revealed a strongly contrast-enhancing mass lesion originating from the dorsal lamina and spinous process of T13. The lesion caused extradural compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation of surgical biopsies was consistent with vertebral osteosarcoma. The cat was paraplegic with intact nociception post-surgery. Subsequently, the cat recovered ambulation while remaining mildly ataxic and paraparetic at long-term follow-up. Post-operative chemotherapy was started with doxorubicin. CT scans at 2, 4, 9, 13, and 20 months post-surgery showed no signs of local recurrence or metastasis. Case 2: A 15.5-year-old male neutered domestic shorthaired cat was presented with progressive paraparesis, tail paresis, and spinal hyperesthesia. Radiographs and CT scan of the lumbar vertebral column showed a large mass originating from the dorsal lamina and spinous process of L6, suggestive of neoplasia, with severe compression of the spinal cord. Surgical debulking was performed, and the histopathological evaluation was consistent with vertebral osteosarcoma. Post-operative chemotherapy was started with doxorubicin. Seven months post-surgery, the patient was neurologically normal with no signs of metastatic disease. This case report highlights the possibility of good outcomes after the surgical treatment of feline vertebral osteosarcoma supplemented with post-surgical chemotherapy.<\/jats:p>","DOI":"10.3390\/ani13223478","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:30:29Z","timestamp":1699842629000},"page":"3478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vertebral Osteosarcoma in Two Cats\u2014Diagnosis, Treatment, and Outcome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-216X","authenticated-orcid":false,"given":"Koen Maurits","family":"Santifort","sequence":"first","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Arnhem, 6825 MB Arnhem, The Netherlands"},{"name":"IVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Beukers","sequence":"additional","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Roos","sequence":"additional","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Nieuwegein, 3433 NP Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"van Rijswoud","sequence":"additional","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Arnhem, 6825 MB Arnhem, The Netherlands"},{"name":"IVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Meertens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal GD, 7418 EZ Deventer, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas","family":"Peperkamp","sequence":"additional","affiliation":[{"name":"Department of Pathology, Royal GD, 7418 EZ Deventer, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Ben-Amotz","sequence":"additional","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Bergknut","sequence":"additional","affiliation":[{"name":"IVC Evidensia Small Animal Referral Hospital Hart van Brabant, 5144 AM Waalwijk, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref_1","first-page":"91","article-title":"Osteosarcoma in cats: 22 cases (1974\u20131984)","volume":"190","author":"Bitetto","year":"1987","journal-title":"J. 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