{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:45:00Z","timestamp":1788374700890,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Province Modern Agricultural Industry Technology System","award":["SDAIT-21-09"],"award-info":[{"award-number":["SDAIT-21-09"]}]},{"name":"Shandong Province Modern Agricultural Industry Technology System","award":["ZR2023QC017"],"award-info":[{"award-number":["ZR2023QC017"]}]},{"name":"Shandong Province Modern Agricultural Industry Technology System","award":["2023TZXD044"],"award-info":[{"award-number":["2023TZXD044"]}]},{"name":"Shandong Province Modern Agricultural Industry Technology System","award":["CARS-43-G-7"],"award-info":[{"award-number":["CARS-43-G-7"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["SDAIT-21-09"],"award-info":[{"award-number":["SDAIT-21-09"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QC017"],"award-info":[{"award-number":["ZR2023QC017"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2023TZXD044"],"award-info":[{"award-number":["2023TZXD044"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["CARS-43-G-7"],"award-info":[{"award-number":["CARS-43-G-7"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Shandong Province (Action Plan for Rural Revitalization of Science and Technology Innovation)","award":["SDAIT-21-09"],"award-info":[{"award-number":["SDAIT-21-09"]}]},{"name":"Key Research and Development Program of Shandong Province (Action Plan for Rural Revitalization of Science and Technology Innovation)","award":["ZR2023QC017"],"award-info":[{"award-number":["ZR2023QC017"]}]},{"name":"Key Research and Development Program of Shandong Province (Action Plan for Rural Revitalization of Science and Technology Innovation)","award":["2023TZXD044"],"award-info":[{"award-number":["2023TZXD044"]}]},{"name":"Key Research and Development Program of Shandong Province (Action Plan for Rural Revitalization of Science and Technology Innovation)","award":["CARS-43-G-7"],"award-info":[{"award-number":["CARS-43-G-7"]}]},{"DOI":"10.13039\/501100009997","name":"Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["SDAIT-21-09"],"award-info":[{"award-number":["SDAIT-21-09"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009997","name":"Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["ZR2023QC017"],"award-info":[{"award-number":["ZR2023QC017"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009997","name":"Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["2023TZXD044"],"award-info":[{"award-number":["2023TZXD044"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009997","name":"Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["CARS-43-G-7"],"award-info":[{"award-number":["CARS-43-G-7"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This experiment was conducted to study the effects of different skinning seasons on the fur quality and hair follicle development of Rex rabbits. A total of 80,150-day-old Rex rabbits were slaughtered on 15 July 2022 (summer), 15 October 2022 (autumn), 15 January 2023 (winter), and 15 April 2023 (spring) in Shandong Province (10 males and 10 females in each season). The results show that the skin weight, skin area, skin thickness, and hair follicle density of the Rex rabbits (at 150 days of age) were lower in summer than in winter (p &lt; 0.05). Moreover, the coat length was shorter in summer than in spring, autumn, and winter (p &lt; 0.05). The shoulder fat weight, perirenal fat weight, and perigastric fat weight of the Rex rabbits in winter were higher than those in summer (p &lt; 0.05). Furthermore, the leptin levels in serum were higher in winter than in summer in the Rex rabbits (p &lt; 0.05). In terms of serum biochemistry, the glucose levels were higher in autumn and winter than in spring and summer (p &lt; 0.05). The cholesterol, high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL) in summer had higher values than in winter in the Rex rabbits (p &lt; 0.05). In winter, the expression of the Wnt10b, catenin beta 1 (CTNNB1), glycogen synthase kinase 3 beta (GSK3\u03b2), insulin like growth factor I (IGF-I), Type I insulin-like growth factor receptor (IGF-IR), and epidermal growth factor (EGF) genes was higher (p &lt; 0.05), and the expression of the dickkopf-1 (DDK1), transforming growth factor beta 1 (TGF\u03b2-1), bone morphogenetic protein 2 (BMP2), and bone morphogenetic protein 4 (BMP4) genes was lower than in summer (p &lt; 0.05). In summer, the heat shock 70 kDa protein (HSP70) expression and CTNNB1 protein phosphorylation levels in skin tissue were higher than in spring, autumn, and winter (p &lt; 0.05). In winter, Wnt10b protein expression was higher (p &lt; 0.05), and GSK-3\u03b2 protein phosphorylation levels were lower than in spring, autumn, and winter (p &lt; 0.05). These results show that the skinning season can affect the production performance and hair follicle development of Rex rabbits. Compared with other seasons, the quality of skin from rabbits slaughtered in winter is better. Seasons may regulate hair follicle development via the Wnt10b\/\u03b2-catenin, TGF\u03b2-BMP, IGF1, and EGF signaling pathways in Rex rabbits.<\/jats:p>","DOI":"10.3390\/ani13233742","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T03:40:58Z","timestamp":1701661258000},"page":"3742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b\/\u03b2-Catenin, TGF\u03b2-BMP, IGF1, and EGF Signaling Pathways"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-7759","authenticated-orcid":false,"given":"Gongyan","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-5721","authenticated-orcid":false,"given":"Liya","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-9667","authenticated-orcid":false,"given":"Shuxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary, Shandong Academy of Agricultural Sciences, Shandong Key Laboratory of Animal Disease Control and Breeding, Key Laboratory of Livestock and Poultry Multiomics of MARA, Jinan 251000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s11250-019-01819-z","article-title":"Milk yield and hair coat characteristics of Holstein cows in a hot environment","volume":"51","author":"Anzures","year":"2019","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101471","DOI":"10.1016\/j.psj.2021.101471","article-title":"Meta-analysis to predict the effects of temperature stress on meat quality of poultry","volume":"100","author":"Leishman","year":"2021","journal-title":"Poultry Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Li, J., Sun, Y., Wang, R., Ma, S., Shi, L., Wang, K., Zhang, H., Wang, T., and Liu, L. (2023). Seasonal differences in intestinal flora are related to rats\u2019 intestinal water metabolism. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1109696"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.theriogenology.2015.03.033","article-title":"Daily exposure to summer temperatures affects the motile subpopulation structure of epididymal sperm cells but not male fertility in an in vivo rabbit model","volume":"84","author":"Taberner","year":"2015","journal-title":"Theriogenology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2014.02.057","article-title":"Transit-amplifying cells orchestrate stem cell activity and tissue regeneration","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1016\/j.cub.2008.12.005","article-title":"The hair follicle as a dynamic miniorgan","volume":"19","author":"Schneider","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","article-title":"Molecular mechanisms regulating hair follicle development","volume":"118","author":"Millar","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.semcdb.2012.08.003","article-title":"Hairy tale of signaling in hair follicle development and cycling","volume":"23","author":"Lee","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3390\/ijms15011647","article-title":"Signaling involved in hair follicle morphogenesis and development","volume":"15","author":"Rishikaysh","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/jmcb\/mjy051","article-title":"A role for the Tgf-beta\/bmp co-receptor endoglin in the molecular oscillator that regulates the hair follicle cycle","volume":"11","author":"Carrasco","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/jpn.13481","article-title":"DNA methylation and histone acetylation are involved in Wnt10b expression during the secondary hair follicle cycle in Angora rabbits","volume":"105","author":"Bai","year":"2021","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhao, B., Li, J., Liu, M., Hu, S., Yang, N., Liang, S., Zhang, X., Dai, Y., Bao, Z., and Chen, Y. (2022). lncRNA2919 suppresses rabbit dermal papilla cell proliferation via trans-regulatory actions. Cells, 11.","DOI":"10.3390\/cells11152443"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.aninu.2021.09.003","article-title":"Pyridoxine regulates hair follicle development via the PI3K\/Akt, Wnt and Notch signalling pathways in rex rabbits","volume":"7","author":"Liu","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22464","DOI":"10.1096\/fj.202200520","article-title":"Methionine can subside hair follicle development prejudice of heat-stressed rex rabbits","volume":"36","author":"Li","year":"2022","journal-title":"FASEB J."},{"key":"ref_16","first-page":"165","article-title":"Biological functions in young pregnant rabbit does as affected by heat stress and lighting regime under subtropical conditions of Egypt","volume":"7","author":"Marai","year":"2007","journal-title":"Trop. Subtrop. Agroecosyst."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wang, Y., Jia, X., Hsieh, J.C.F., Monson, M.S., Zhang, J., Shu, D., Nie, Q., Persia, M.E., Rothschild, M.F., and Lamont, S.J. (2021). Transcriptome response of liver and muscle in heat-stressed laying hens. Genes, 12.","DOI":"10.3390\/genes12020255"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1071\/AN15807","article-title":"Effects of dietary vitamin B6 on the skeletal muscle protein metabolism of growing rabbits","volume":"57","author":"Liu","year":"2017","journal-title":"Anim. Prod. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"LiLivak","year":"2001","journal-title":"Methods"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liu, G., Li, S., Liu, H., Zhu, Y., Bai, L., Sun, H., Gao, S., Jiang, W., and Li, F. (2020). The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits. BMC Dev. Biol., 20.","DOI":"10.1186\/s12861-020-00213-5"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100096","DOI":"10.1016\/j.animal.2020.100096","article-title":"Effect of ambient temperature on the productive and carcass traits of growing rabbits divergently selected for body fat content","volume":"15","author":"Matics","year":"2021","journal-title":"Animal"},{"key":"ref_23","first-page":"119","article-title":"Effect of genotype and environmental temperature on the performance of the young meat rabbit","volume":"1","author":"Chiericato","year":"1993","journal-title":"World Rabbit Sci."},{"key":"ref_24","first-page":"35","article-title":"Growth performance, some blood metabolites and carcass traits of New Zealand White broiler male rabbits as affected by heat stress and its alleviation, under Egyptian conditions","volume":"41","author":"Marai","year":"1999","journal-title":"Cah. Options M\u00e9diterran\u00e9ennes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1017\/S1751731112001838","article-title":"Carcass and meat quality traits of rabbits under heat stress","volume":"7","author":"Zeferino","year":"2013","journal-title":"Animal"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ps\/86.6.1059","article-title":"Effect of chronic heat exposure on fat deposition and meat quality in two genetic types of chicken","volume":"86","author":"Lu","year":"2007","journal-title":"Poultry Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101217","DOI":"10.1016\/j.psj.2021.101217","article-title":"Effect of phloretin ongrowth performance, serum biochemical parameters and antioxidant profile in heat-stressed broilers","volume":"100","author":"Hu","year":"2021","journal-title":"Poultry Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/jpn.12379","article-title":"Heat stress effects on livestock: Molecular, cellular and metabolic aspects, a review","volume":"100","author":"Slimen","year":"2016","journal-title":"J. Anim. Physio. Anim. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuron.2004.06.004","article-title":"Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis","volume":"42","author":"Balthasar","year":"2004","journal-title":"Neuron"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI0215693","article-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","volume":"110","author":"Farooqi","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43801","DOI":"10.1074\/jbc.M106695200","article-title":"Scavenger receptor class B, type I-mediated uptake of various lipids into cells. Influence of the nature of the donor particle interaction with the receptor","volume":"276","author":"Thuahnai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0300-9629(91)90327-9","article-title":"Effects of warm exposure on adipose tissue and muscle metabolism in growing pigs","volume":"100","author":"Rinaldo","year":"1991","journal-title":"Comp. Biochem. Phys. Part A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/jpn.13044","article-title":"Heat stress decreased hair follicle population in rex rabbits","volume":"103","author":"Sun","year":"2019","journal-title":"J. Anim. Physio. Anim. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.18632\/aging.102136","article-title":"HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress","volume":"11","author":"Wang","year":"2019","journal-title":"Aging"},{"key":"ref_37","first-page":"4449","article-title":"MicroRNA-195 suppresses rectal cancer growth and metastasis via regulation of the PI3K\/AKT signaling pathway","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1017\/S1751731120000075","article-title":"Identification of heat shock protein gene expression in hair follicles as a novel indicator of heat stress in beef calves","volume":"14","author":"Kim","year":"2020","journal-title":"Animal"},{"key":"ref_39","first-page":"290","article-title":"Gene regulation by Wnt signaling pathway in the oriented differentiation of hair follicle stem cells","volume":"7","author":"Xiang","year":"2011","journal-title":"J. Tissue Eng. Reconstr. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10735-015-9616-5","article-title":"Expression of Wnt\/\u03b2-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles","volume":"46","author":"Lin","year":"2015","journal-title":"J. Mol. Histol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wu, Z., Zhu, Y., Liu, H., Liu, H., and Li, F. (2020). Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt\/\u03b2-Catenin signaling pathway in Rex rabbits. Biosci. Rep., 40.","DOI":"10.1042\/BSR20191248"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cell.2010.11.034","article-title":"Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes","volume":"143","author":"Taelman","year":"2010","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/jid.2012.24","article-title":"Dickkopf 1 promotes regression of hair follicles","volume":"132","author":"Kwack","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1634\/stemcells.2005-0544","article-title":"Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem\/progenitor cell activation and expansion","volume":"24","author":"Zhang","year":"2006","journal-title":"Stem Cells"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1101\/gad.1614408","article-title":"BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties","volume":"22","author":"Rendl","year":"2008","journal-title":"Gene Develop."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1093\/emboj\/19.24.6664","article-title":"Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle","volume":"19","author":"Kulessa","year":"2000","journal-title":"EMBO J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.stem.2011.11.005","article-title":"Paracrine TGF-beta signaling counterbalances BMP-mediated repression in hair follicle stem cell activation","volume":"10","author":"Oshimori","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/1523-1747.ep12382494","article-title":"Effects of insulin and insulinlike growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro","volume":"102","author":"Philpott","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1051\/animres:19870407","article-title":"Epidermal growth factor (EGF) facilitates depilation of the angora rabbit","volume":"36","author":"Moore","year":"1987","journal-title":"Ann. Zootech."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/1523-1747.ep12371760","article-title":"Effects of EGF on the morphology and patterns of DNA synthesis in isolated human hair follicles","volume":"102","author":"Philpott","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.031427","article-title":"KGF and EGF signaling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin","volume":"136","author":"Richardson","year":"2009","journal-title":"Development"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/23\/3742\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:37:21Z","timestamp":1760132241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/13\/23\/3742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":51,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["ani13233742"],"URL":"https:\/\/doi.org\/10.3390\/ani13233742","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]}}}