{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:33:57Z","timestamp":1791999237842,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qingdao Science and Technology Program","award":["22-3-7-xdny-11-nsh"],"award-info":[{"award-number":["22-3-7-xdny-11-nsh"]}]},{"name":"Qingdao Science and Technology Program","award":["23-2-8-xdny-8-nsh"],"award-info":[{"award-number":["23-2-8-xdny-8-nsh"]}]},{"name":"Qingdao Science and Technology Program","award":["ZR2021MC118"],"award-info":[{"award-number":["ZR2021MC118"]}]},{"name":"Qingdao Science and Technology Program","award":["QNYCX22006"],"award-info":[{"award-number":["QNYCX22006"]}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["22-3-7-xdny-11-nsh"],"award-info":[{"award-number":["22-3-7-xdny-11-nsh"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["23-2-8-xdny-8-nsh"],"award-info":[{"award-number":["23-2-8-xdny-8-nsh"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2021MC118"],"award-info":[{"award-number":["ZR2021MC118"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["QNYCX22006"],"award-info":[{"award-number":["QNYCX22006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postgraduate Innovation Program of Qingdao Agricultural University","award":["22-3-7-xdny-11-nsh"],"award-info":[{"award-number":["22-3-7-xdny-11-nsh"]}]},{"name":"Postgraduate Innovation Program of Qingdao Agricultural University","award":["23-2-8-xdny-8-nsh"],"award-info":[{"award-number":["23-2-8-xdny-8-nsh"]}]},{"name":"Postgraduate Innovation Program of Qingdao Agricultural University","award":["ZR2021MC118"],"award-info":[{"award-number":["ZR2021MC118"]}]},{"name":"Postgraduate Innovation Program of Qingdao Agricultural University","award":["QNYCX22006"],"award-info":[{"award-number":["QNYCX22006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The purpose of the study was to investigate the effects of Lactobacillus plantarum HW1 on growth performance, intestinal immune response, barrier function, and cecal microflora of broilers with necrotic enteritis. In total, 180 one-day-old male Cobb 500 broilers were randomly allocated into three groups comprising a non-infected control (NC) group, basal diet + necrotic enteritis challenge (NE) group, and basal diet + 4 \u00d7 106 CFU\/g Lactobacillus plantarum HW1 + necrotic enteritis challenge (HW1) group. Broilers in the NE and HW1 groups were orally given sporulated coccidian oocysts at day 14 and Clostridium perfringens from days 19 to 21. The results showed that the HW1 treatment increased (p &lt; 0.05) the average daily gain of broilers from days 15 to 28 and from days 0 to 28 compared with the NE group. Moreover, the HW1 treatment decreased (p &lt; 0.05) the oocysts per gram of excreta, intestinal lesion scores, ileal interleukin (IL) 1\u03b2 and tumor necrosis factor \u03b1 levels, and serum D-lactic acid and diamine oxidase levels, while increasing (p &lt; 0.05) the ileal IL-10 level, thymus index, and protein expressions of ileal occludin and ZO-1. Additionally, the HW1 treatment decreased (p &lt; 0.05) the jejunal and ileal villus height, jejunal villus height\/crypt depth value, and cecal harmful bacterial counts (Clostridium perfringens, Salmonella, Escherichia coli, and Staphylococcus aureus), and increased (p &lt; 0.05) the cecal Lactobacillus count. In conclusion, dietary supplementation with 4 \u00d7 106 CFU\/g Lactobacillus plantarum HW1 could relieve necrotic enteritis infection-induced intestinal injury and improve growth performance in broilers by improving intestinal barrier function and regulating intestinal microbiology.<\/jats:p>","DOI":"10.3390\/ani13243810","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T11:24:43Z","timestamp":1702293883000},"page":"3810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of Lactobacillus plantarum HW1 on Growth Performance, Intestinal Immune Response, Barrier Function, and Cecal Microflora of Broilers with Necrotic Enteritis"],"prefix":"10.3390","volume":"13","author":[{"given":"Peng","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyan","family":"Che","sequence":"additional","affiliation":[{"name":"College of Animal Science, Anhui Science and Technology University, Fengyang 233100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/21505594.2021.1886777","article-title":"Pathogenicity and virulence of Clostridium perfringens","volume":"12","author":"Mehdizadeh","year":"2021","journal-title":"Virulence"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1637\/aviandiseases-D-22-00003","article-title":"Toxinotyping of Clostridium perfringens strains recovered from U.S. turkeys with necrotic enteritis","volume":"66","author":"Smyth","year":"2022","journal-title":"Avian Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.psj.2020.10.019","article-title":"Characterization of a novel bacteriophage \u03c6CJ22 and its prophylactic and inhibitory effects on necrotic enteritis and Clostridium perfringens in broilers","volume":"100","author":"Bae","year":"2021","journal-title":"Poult. 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