{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:35:44Z","timestamp":1792100144303,"version":"4.4.0"},"reference-count":75,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The \u201cELEVATE\u201d Ph.D. scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The poultry industry contributes significantly to the global meat industry but faces many production challenges like high-density housing, welfare issues, and pathogenic infections. While antibiotics have commonly been used to treat many of these issues, they are being removed from poultry production globally due to increased microbial resistance. Precision glycans offer a viable alternative to antibiotics by modulating microbial metabolic pathways. In this study, we investigated the effects of precision glycan supplementation on productivity and gut microbiota in broilers. The experiment was conducted in a commercial setting using 32,400 male Ross chickens randomly divided into three sheds with 10,800 birds each. One shed with 12 pen replicates of 900 birds was used as control, while the other two with an equal number of replicates and birds were assigned to precision glycan supplementation. The treatment significantly improved the average daily weight gain and feed conversion ratio, with a significant modification in the abundance of several bacterial taxa in the caecum, ileum, and ileum mucosa microbial communities. There was increased richness and diversity in the caecum, with a reduction in Proteobacteria and an increase in Firmicutes. Richness remained unchanged in the ileum, with an increase in diversity and reduction in pathogenic genera like Clostridium and Escherichia-Shigella. Ileum mucosa showed a lower abundance of mucin degraders and an increased presence of next-generation probiotics. Supplemented birds showed a high level of disease resistance when the farm experienced an outbreak of infectious bronchitis, evidenced by lower mortality. Histological analysis confirmed improvements in the ileum and liver health, where the precision glycan supplementation reduced the area of congested sinusoids compared to the control group in the liver and significantly improved ileum intestinal morphology by increasing crypt depth and surface area. These results collectively suggest that precision glycans offer substantial benefits in poultry production by improving productivity, gut health, and disease resistance.<\/jats:p>","DOI":"10.3390\/ani14010032","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:36:17Z","timestamp":1703129777000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Precision Glycan Supplementation Improves Gut Microbiota Diversity, Performance, and Disease Outbreak Resistance in Broiler Chickens"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4388-4849","authenticated-orcid":false,"given":"Edina","family":"Lobo","sequence":"first","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3043-071X","authenticated-orcid":false,"given":"Yadav S.","family":"Bajagai","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-1516","authenticated-orcid":false,"given":"Advait","family":"Kayal","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ramirez","sequence":"additional","affiliation":[{"name":"DSM Firmenich, 4303 Kaiseraugst, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobodjenja 18, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Valientes","sequence":"additional","affiliation":[{"name":"DSM Firmenich, 4303 Kaiseraugst, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-4726","authenticated-orcid":false,"given":"Dragana","family":"Stanley","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100755","DOI":"10.1016\/j.animal.2023.100755","article-title":"Review: Current challenges in poultry nutrition, health, and welfare","volume":"17","author":"Korver","year":"2023","journal-title":"Animal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tifs.2017.04.016","article-title":"Review: Nutrient density and nutritional value of meat products and non-meat foods high in protein","volume":"65","author":"Bohrer","year":"2017","journal-title":"Trends Food Sci. 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